T10718L |
CCT241533 hydrochloride
|
1431697-96-9
|
98%
|
|
CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).
|
TN1458 |
Buddlejasaponin IV
|
139523-30-1
|
98%
|
|
Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-ka...
|
T17223 |
VER-00158411
|
1174664-88-0
|
98%
|
|
VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).
|
T10790 |
CHK1-IN-2
|
912367-45-4
|
98%
|
|
CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).
|
T16848 |
SB-218078
|
135897-06-2
|
98%
|
|
SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1 i...
|
T10793 |
CHK1 inhibitor
|
2097938-64-0
|
98%
|
|
CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.
|
T10718 |
CCT241533
|
1262849-73-9
|
98%
|
|
CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).
|
T14904 |
CCT244747
|
1404095-34-6
|
98%
|
|
CCT244747 is a CHK1 inhibitor (IC50: 7.7 nM) and also abrogates G2 checkpoint (IC50: 29 nM).
|
T10792 |
CHK1-IN-4
|
2120398-41-4
|
98%
|
|
CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.
|
T11960 |
MBM-55
|
2083622-09-5
|
99.98%
|
|
MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing...
|
T9252 |
LY2880070
|
1375637-35-6
|
99.95%
|
|
LY2880070 is a new checkpoint kinase 1 (CHK1) inhibitor for cancer therapy.
|
T3700 |
SCH900776 (S-isomer)
|
891494-64-7
|
99.95%
|
|
SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM). It also inhibitors Chk2...
|
T83321 |
4-Demethyldeoxypodophyllotoxin
|
3590-93-0
|
99.89%
|
|
4-Demethyldeoxypodophyllotoxin, an aryl tetrahydronaphthalenyl lignan analog from the roots of Podophyllum peltatum, has anticancer activity and modulates the Ch...
|
T2485 |
Baricitinib
|
1187594-09-7
|
99.79%
|
|
Baricitinib (INCB028050) is an orally bioavailable inhibitor of Janus kinases 1 and 2 (JAK1/2), with potential anti-inflammatory, immunomodulating and antineopla...
|
T10406 |
Tuvusertib
|
1613200-51-3
|
99.66%
|
|
Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µΜ) with selective and potentially antitumor activ...
|
T6931 |
PD0166285
|
185039-89-8
|
99.59%
|
|
PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator.
|
T1837 |
BX-912
|
702674-56-4
|
99.34%
|
|
BX-912 is a specific inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1, IC50: 12 nM). The selectivity of BX-912 is more 10 fold than C-Kit, EGFR, PKA, PKC...
|
T10325 |
ANI-7
|
931417-26-4
|
99.21%
|
|
ANI-7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells and potently and selectively inhibits the gr...
|
T6093 |
AZD-7762
|
860352-01-8
|
99.17%
|
|
AZD-7762, an effective and specific inhibitor of Chk1(IC50=5 nM), is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.
|
T6084 |
Rabusertib
|
911222-45-2
|
98.86%
|
|
Rabusertib (IC-83) is an inhibitor of the cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiating activity. Rabusertib has been used in trials stu...
|