Chk

Checkpoint kinase 1, commonly referred to as Chk1, is a serine/threonine-specific protein kinase that, in humans, is encoded by the CHEK1 gene. Chk1 coordinates the DNA damage response (DDR) and cell cycle checkpoint response. Activation of Chk1 results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death to prevent damaged cells from progressing through the cell cycle.

Cat. No.	Product name	CAS No.	Purity	Chemical Structure
T15943	M443	1820684-31-8	98.95%
T15943	M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research.
T6350	CHIR-124	405168-58-3	98.35%
T6350	CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.
T2517	SCH900776	891494-63-6	98.35%
T2517	SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.
T1830	BX795	702675-74-9	98.32%
T1830	BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respect...
T7080	CCT245737	1489389-18-5	98.06%
T7080	CCT245737 (SRA737) is an orally active and selective Chk1 inhibitor (IC50: 1.3 nM); CCT245737 shows much less activity against Chk2 (IC50: 2440 nM).
T10792L	CHK1-IN-4 hydrochloride		98.02%
T10792L	CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1). CHK1-IN-4 hydrochloride potently inhibits chk1 phosphorylation in the tumor cells. C...
T7300	GDC-0575	1196541-47-5	98%
T7300	GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).
T2033	BML-277	516480-79-8	98%
T2033	BML-277 (C 3742) is a selective checkpoint kinase 2 (Chk2) inhibitor.
T27407	GDC0575 monohydrochloride	1196504-54-7	97.85%
T27407	GDC0575 monohydrochloride (ARRY575) is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically bi...
T21331	SAR-020106	1184843-57-9	97.78%
T21331	SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.
T4327	Prexasertib dihydrochloride	1234015-54-3	97.5%
T4327	Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2...
T71259	GNE-900	1200126-26-6	97.18%
T71259	GNE-900 is an ATP-competitive ChK1 inhibitor with selective and oral activity.GNE-900 inhibits ChKl and ChK2 with IC50 values of 0.0011 and 1.5 µM, respectively....
T10791	CHK1-IN-3	2097252-39-4	100%
T10791	CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).
T13148	CHK-IN-1	1278405-51-8	100%
T13148	CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.
T4310	Prexasertib	1234015-52-1	100%
T4310	Prexasertib (LY2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity.
T16446	PD 407824	622864-54-4	98%
T16446	PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkp...
T76691	Monalizumab	1228763-95-8	98%	Monalizumab
T76691	Monalizumab is a novel immune checkpoint inhibitor targeting natural killer cell population 2A (NKG2A). Monalizumab is a humanized monoclonal antibody against NK...			Monalizumab
T6028	PF 477736	952021-60-2	98%
T6028	PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CS...
T14072	A-443654	552325-16-3	98%
T14072	A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).