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Cysteine Protease

Cysteine proteases, also known as thiol proteases, are enzymes that degrade proteins. These proteases share a common catalytic mechanism that involves a nucleophilic cysteine thiol in a catalytic triad or dyad.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T15303 FMK 9a 1955550-51-2 98.97%
FMK 9a
FMK 9a is an irreversible inhibitor of ATG4B with IC50 values of 80 and 73 nM in the TR-FRET and cellular-based LRA assays.
TN1249 3-Epiursolic acid 989-30-0 98.81%
3-Epiursolic acid
3-Epiursolic acid may have antiinflammatory activity, it shows inhibition on Cathepsins L (catL), the IC50 value of 6.5 μM, cathepsins L (catL) and B play an imp...
T27695 JTE-607 188791-09-5 98.72%
JTE-607
JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.
T27730 KGP94 1131456-28-4 98.52%
KGP94
KGP94 is an inhibitor of cysteine protease Cathepsin L(CTSL).
T21616 L-006235 294623-49-7 98.38%
L-006235
L-006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.
T19384 Isovalerylcarnitine 31023-24-2 98.24%
Isovalerylcarnitine
Isovalerylcarnitine (3-methylbutyrylcarnitine) is a small molecule compound produced by the catabolism of L-leucine and the accumulation of isovaleric acid. Isov...
T20626 Esomeprazole 119141-88-7 98.20%
Esomeprazole
Esomeprazole is the S-isomer of omeprazole, inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis. Esomeprazole is a proton pump inhibit...
T12909 SID 26681509 958772-66-2 98.16%
SID 26681509
SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).
T60150 (1S,2R)-Alicapistat 2221010-57-5 98.05%
(1S,2R)-Alicapistat
(1S,2R)-Alicapistat ((1S,2R)-ABT-957) is a highly efficient, orally active compound that selectively inhibits human calpains 1 and 2, with promising implications...
T6583 MG-101 110044-82-1 98%
MG-101
MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.
T3088 N-Ethylmaleimide 128-53-0 98%
N-Ethylmaleimide
N-Ethylmaleimide (NEM) is a sulfhydryl reagent that is widely used in experimental biochemical studies.
T7451 2-Cyanopyrimidine 14080-23-0 98%
2-Cyanopyrimidine
2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) is inhibitor of cathepsin K(IC50 : 170 nM)
TQ0116 LY 3000328 1373215-15-6 97.83%
LY 3000328
LY 3000328 (Cathepsin S inhibitor) is a potent, highly selective Cathepsin S (Cat S) inhibitor (IC50s: 7.7 and 1.67 nM for hCat S and mCat S).
T21509 CA 074 134448-10-5 97.80%
CA 074
CA 074 is a potent inhibitor of cathepsin B with a Ki value of 2 to 5 nM.CA 074 inhibits ischemic hippocampal neuronal death in primates and attenuates retinopat...
T1850 Balicatib 354813-19-7 97.78%
Balicatib
Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.
T3420 CA-074 methyl ester 147859-80-1 97.26%
CA-074 methyl ester
CA-074 methyl ester (Cathepsin B Inhibitor IV) is a specific inhibitor of Cathepsin B with neuroprotective, anti-cancer, and anti-inflammatory effects.
T16089 MK-0674 887781-62-6 100%
MK-0674
MK-0674 is an orally available, selective and potent cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S. It can be used in metabol...
T0448 (S)-(+)-Ibuprofen 51146-56-6 100%
(S)-(+)-Ibuprofen
(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
T2470 MDL-28170 88191-84-8
MDL-28170
MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.
T19503 Papain 9001-73-4
Papain
Papain is a cysteine protease of the peptidase C1 family. Papain is used in food, pharmaceutical, textile, and cosmetic industries.
FMK 9a
T15303
FMK 9a is an irreversible inhibitor of ATG4B with IC50 values of 80 and 73 nM in the TR-FRET and cellular-based LRA assays.
3-Epiursolic acid
TN1249
3-Epiursolic acid may have antiinflammatory activity, it shows inhibition on Cathepsins L (catL), the IC50 value of 6.5 μM, cathepsins L (catL) and B play an imp...
JTE-607
T27695
JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.
KGP94
T27730
KGP94 is an inhibitor of cysteine protease Cathepsin L(CTSL).
L-006235
T21616
L-006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.
Isovalerylcarnitine
T19384
Isovalerylcarnitine (3-methylbutyrylcarnitine) is a small molecule compound produced by the catabolism of L-leucine and the accumulation of isovaleric acid. Isov...
Esomeprazole
T20626
Esomeprazole is the S-isomer of omeprazole, inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis. Esomeprazole is a proton pump inhibit...
SID 26681509
T12909
SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).
(1S,2R)-Alicapistat
T60150
(1S,2R)-Alicapistat ((1S,2R)-ABT-957) is a highly efficient, orally active compound that selectively inhibits human calpains 1 and 2, with promising implications...
MG-101
T6583
MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.
N-Ethylmaleimide
T3088
N-Ethylmaleimide (NEM) is a sulfhydryl reagent that is widely used in experimental biochemical studies.
2-Cyanopyrimidine
T7451
2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) is inhibitor of cathepsin K(IC50 : 170 nM)
LY 3000328
TQ0116
LY 3000328 (Cathepsin S inhibitor) is a potent, highly selective Cathepsin S (Cat S) inhibitor (IC50s: 7.7 and 1.67 nM for hCat S and mCat S).
CA 074
T21509
CA 074 is a potent inhibitor of cathepsin B with a Ki value of 2 to 5 nM.CA 074 inhibits ischemic hippocampal neuronal death in primates and attenuates retinopat...
Balicatib
T1850
Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.
CA-074 methyl ester
T3420
CA-074 methyl ester (Cathepsin B Inhibitor IV) is a specific inhibitor of Cathepsin B with neuroprotective, anti-cancer, and anti-inflammatory effects.
MK-0674
T16089
MK-0674 is an orally available, selective and potent cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S. It can be used in metabol...
(S)-(+)-Ibuprofen
T0448
(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
MDL-28170
T2470
MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.
Papain
T19503
Papain is a cysteine protease of the peptidase C1 family. Papain is used in food, pharmaceutical, textile, and cosmetic industries.
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TargetMol