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Cysteine Protease

Cysteine proteases, also known as thiol proteases, are enzymes that degrade proteins. These proteases share a common catalytic mechanism that involves a nucleophilic cysteine thiol in a catalytic triad or dyad.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T6564 Leupeptin Hemisulfate 103476-89-7 98%
Leupeptin Hemisulfate
Leupeptin hemisulfate is a protease inhibitor with cell membrane-permeable, reversible, competitive, and oral activities. Leupeptin hemisulfate inhibits the acti...
T13288 VBY-825 1310340-58-9 98%
VBY-825
VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.
T13911 Tacalcitol monohydrate 93129-94-3 98%
Tacalcitol monohydrate
Tacalcitol monohydrate(Curatoderm monohydrate), a vitamin D3 analog that promotes bone development by regulating calcium ions, can be used to study psoriasis.
T5211 NSC 185058 39122-38-8 98%
NSC 185058
NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.
T37753 Aureusimine B 170713-71-0 98%
Aureusimine B
Aureusimine B, also known as phevalin, is a natural pyrazinone produced by certain fungi and by Staphylococcus spp., including S. aureus. Its synthesis appears t...
T6432 Calpeptin 117591-20-5 98%
Calpeptin
Calpeptin is a potent, cell-permeable calpain inhibitor.
T6037 E-64 66701-25-5 98%
E-64
E-64 (Proteinase inhibitor E 64) is an irreversible and specific cysteine protease inhibitor. The IC50 of E-64 for papain is 9 nM.
T2493 PD 151746 179461-52-0 98%
PD 151746
PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). Its IC50 values are 0.26 ± 0...
T6035 Odanacatib 603139-19-1 98%
Odanacatib
Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity.
TP2056L Acetyl-Calpastatin (184-210)(human) acetate 98%
Acetyl-Calpastatin (184-210)(human) acetate
Acetyl-Calpastatin (184-210)(human) acetate is a potent, selective and reversible calpain inhibitor with Ki values of 0.2 nM and 6 μM for µ-calpain and cathepsin...
T38469 (Rac)-Z-Phe-Phe-FMK 108005-94-3 98%
(Rac)-Z-Phe-Phe-FMK
(Rac)-Z-Phe-Phe-FMK (Cathepsin L-IN-2) is a cathepsin L inhibitor that inhibits the tendency of β-amyloid to induce apoptotic changes .
T1080 2-Aminoethanethiol 60-23-1 98%
2-Aminoethanethiol
2-Aminoethanethiol (Cysteamine) is a Cystine Depleting Agent. The mechanism of action of cysteamine is as a Cystine Disulfide Reduction.
T6573 E 64c 76684-89-4 98%
E 64c
E 64c (EP 475) , a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.
Leupeptin Hemisulfate
T6564
Leupeptin hemisulfate is a protease inhibitor with cell membrane-permeable, reversible, competitive, and oral activities. Leupeptin hemisulfate inhibits the acti...
VBY-825
T13288
VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.
Tacalcitol monohydrate
T13911
Tacalcitol monohydrate(Curatoderm monohydrate), a vitamin D3 analog that promotes bone development by regulating calcium ions, can be used to study psoriasis.
NSC 185058
T5211
NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.
Aureusimine B
T37753
Aureusimine B, also known as phevalin, is a natural pyrazinone produced by certain fungi and by Staphylococcus spp., including S. aureus. Its synthesis appears t...
Calpeptin
T6432
Calpeptin is a potent, cell-permeable calpain inhibitor.
E-64
T6037
E-64 (Proteinase inhibitor E 64) is an irreversible and specific cysteine protease inhibitor. The IC50 of E-64 for papain is 9 nM.
PD 151746
T2493
PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). Its IC50 values are 0.26 ± 0...
Odanacatib
T6035
Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity.
Acetyl-Calpastatin (184-210)(human) acetate
TP2056L
Acetyl-Calpastatin (184-210)(human) acetate is a potent, selective and reversible calpain inhibitor with Ki values of 0.2 nM and 6 μM for µ-calpain and cathepsin...
(Rac)-Z-Phe-Phe-FMK
T38469
(Rac)-Z-Phe-Phe-FMK (Cathepsin L-IN-2) is a cathepsin L inhibitor that inhibits the tendency of β-amyloid to induce apoptotic changes .
2-Aminoethanethiol
T1080
2-Aminoethanethiol (Cysteamine) is a Cystine Depleting Agent. The mechanism of action of cysteamine is as a Cystine Disulfide Reduction.
E 64c
T6573
E 64c (EP 475) , a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.
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TargetMol