DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.

Cat. No.	Product name	CAS No.	Purity
T60420	Anticancer agent 73	124811-87-6	99.19%
T60420	Anticancer agent 73 is an anticancer agent which potently targets transactivation response(TAR) RNA-binding protein 2 (TRBP) and disrupts the TRBP-Dicer interac...
T9275	ART558	2603528-97-6	99.18%
T9275	ART558 is a potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC50=7.9 nM). ART558 can be used for the research of c...
T1154	Rifaximin	80621-81-4	99.18%
T1154	Rifaximin is an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. Rifaximin binds to the beta-su...
T16703	Quarfloxin	865311-47-3	99.18%
T16703	Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disr...
T20945	2,4-D	94-75-7	99.16%
T20945	2,4-Dichlorophenoxyacetic acid (Hedonal) is a synthetic auxin used as a plant growth regulator and also used as a supplement in plant cell culture media. It is a...
T10343	AOH1160	2089314-57-6	99.16%
T10343	AOH1160 is an inhibitor of proliferating cell nuclear antigen (PCNA). AOH1160 induces apoptosis and causes cell-cycle arrest by interfering with DNA replication....
T6226	Pemetrexed disodium hemipenta hydrate	357166-30-4	99.16%
T6226	Pemetrexed disodium hemipenta hydrate (LY-231514 Disodium Hydrate) is a new-type antifolate and antimetabolite for TS, DHFR, and GARFT. The Ki of Pemetrexed Diso...
T3772	Maslinic acid	4373-41-5	99.16%
T3772	Maslinic acid (Crategolic acid) is a DNA polymerase B inhibitor.
T8647	BCH001	384859-58-9	99.15%
T8647	BCH001 is a specific small-molecule inhibitor of PAPD5.
T6244	Cidofovir	113852-37-2	99.13%
T6244	Cidofovir ((S)-HPMPC) inhibits virus replication by specific inhibition of viral DNA synthesis.
T13231L	Trovafloxacin mesylate	147059-75-4	99.12%
T13231L	Trovafloxacin is a broad-spectrum fluoroquinolone antibiotic that inhibits the activity of DNA gyrase and topoisomerase IV, enzymes involved in DNA replication. ...
T0353	Osalmid	526-18-1	99.08%
T0353	Osalmid (Oxaphenamide) is a choleretic drug, inhibits ribonucleotide reductase activity by targeting ribonucleotide reductase small subunit M2 (RRM2).
T9350	IMP-1088	2059148-82-0	99.08%
T9350	IMP-1088 is a potent inhibitor of human N-myristoyltransferases NMT1 and NMT2 dual.
T6632	Raltitrexed	112887-68-0	99.06%
T6632	Raltitrexed (D1694)(IC50 of 9 nM), a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth.
T10936	D-I03	688342-78-1	99.04%
T10936	D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM. D-I03 specifically inhibits RAD52-dependent single-chain annealing (SSA) and D-loop formation, with IC...
T1665	Daptomycin	103060-53-3	99.02%
T1665	Daptomycin (LY146032) is a cyclic lipopeptide antibiotic that inhibits GRAM-POSITIVE BACTERIA.
T8785	HALOFUGINONE LACTATE	82186-71-8	99.02%
T8785	HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone ...
T73475	SMN-C2	1446311-56-3	99.01%
T73475	SMN-C2 is a selective regulator of SMN2 gene splicing, a risdiplam analogue, a selective RNA-binding ligand that regulates pre-mRNA splicing and acts by binding ...
T80644	DNA polymerase-IN-1	809234-33-1	99%
T80644	DNA polymerase-IN-1, a DNA polymerase inhibitor, exhibited antiproliferative activity against tumor cells with a half-inhibitory concentration (IC50) of 20.7 μM....
T2201	6-Mercaptopurine hydrate	6112-76-1	99%
T2201	6-Mercaptopurine hydrate (6-Mercaptopurine monohydrate) is a Nucleoside Metabolic Inhibitor. It interferes with nucleic acid synthesis by inhibiting purine metab...