DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.

Cat. No.	Product name	CAS No.	Purity
T36752	Dmt-2'fluoro-da(bz) amidite	136834-22-5	98.15%
T36752	Dmt-2'fluoro-da(bz) amidite is a 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotide with high affinity and specificity for RNA targets.Dmt-2'fluoro-da(bz) amidi...
T1233	Oxolinic acid	14698-29-4	98.15%
T1233	Oxolinic acid (Nidantin) is a synthetic antimicrobial related to NALIDIXIC ACID and used in URINARY TRACT INFECTIONS.
T8841	IMT1	2304621-31-4	98.14%
T8841	IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) has anticancer activity.
T4382	Proguanil hydrochloride	637-32-1	98.13%
T4382	Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguani...
T9715	Aplidine	137219-37-5	98.12%
T9715	Aplidine possesses antiviral activity against SARS-CoV-2(IC90 = 0.88 nM). Aplidine is a potent anti-cancer agent by targeting eukaryotic translation elongation f...
T40661	ML-60218	577784-91-9	98.1%
T40661	ML-60218 is an inhibitor of broad-spectrum RNA pol III with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled vir...
T67731	Holomycin	488-04-0	98.09%
T67731	Holomycin (N-Demethylthiolutin) is a secondary metabolite of dithiopyrrolidone. HolomycinHolomycin, an antibiotic secondary metabolite, is required for the biofi...
T6752	S-Adenosyl-L-methionine disulfate tosylate	97540-22-2	98.05%
T6752	S-Adenosyl-L-methionine disulfate tosylate (Ademetionine disulfate tosylate) is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademeti...
T0095	Bendamustine hydrochloride	3543-75-7	98.03%
T0095	Bendamustine hydrochloride (EP-3101) (IC50 of 50 μM) is an alkylating agent associated with DNA damage.
T10384	Farudodstat	1035688-66-4	98.03%
T10384	Farudodstat (ASLAN003) is an orally active and potent inhibitor of DHODH (Human Dihydroorotate Dehydrogenase) with antitumor activity. It has the potential to be...
T15235	Enocitabine	55726-47-1	98.02%
T15235	Enocitabine is a nucleoside analog. Enocitabine inhibits the replication of human cytomegalovirus(HCMV) and it also has antileukemic and antiviral activities. En...
T7518	Deoxycytidine triphosphate trisodium salt	109909-44-6	98%
T7518	Deoxycytidine triphosphate trisodium salt (2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE TRISODI) contributes to antibiotic lethality in stationary-phase mycobacteria.
T1840	Isoindigotin	476-34-6	98%
T1840	Isoindigotin is used in the therapy of Y.
T1428	Trifluridine	70-00-8	98%
T1428	Trifluridine (NSC-75520) is a fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate...
T82568	DHX9-IN-2	2973395-71-8	98%
T82568	DHX9-IN-2 is an inhibitor targeting ATP-dependent RNA de-helicase A (DHX9) with anticancer and antitumor activity for cancer research.
T7539	O6-Benzylguanine	19916-73-5	98%
T7539	O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
T7409	360A	794458-56-3	98%
T7409	360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).
T1598	Rimantadine hydrochloride	1501-84-4	98%
T1598	Rimantadine hydrochloride (Meradane) is an RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.
T6456	CRT0044876	6960-45-8	98%
T6456	CRT0044876 (7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM.
T6116	Bleomycin Sulfate	9041-93-4	98%
T6116	Bleomycin Sulfate (Blenoxane) is a glycopeptide antibiotic, an inhibitor of DNA synthesis. Bleomycin Sulfate causes DNA strand breaks but not RNA strand breaks. ...