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DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T0802 Procaine hydrochloride 51-05-8 98%
Procaine hydrochloride
Procaine hydrochloride (Novocaine HCl) is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties....
T2708 SL327 305350-87-2 98%
SL327
SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.
TWP2911 Thymidine 50-89-5 98%
Thymidine
1. Thymidine (DThyd) overload due to Thymidine phosphorylase deficiency, and mitochondrial toxicity caused by antiviral Thymidine analogues.
T4356 POL1-IN-1 1822358-25-7 98%
POL1-IN-1
POL1-IN-1 (Compound 3A) can effectively inhibit the transcription of RNA polymerase I in the A375 malignant melanoma cell line but has no effect on polymerase II...
T6801 CeMMEC13 1790895-25-8 97.95%
CeMMEC13
CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 μM).
T4228 Nolatrexed 147149-76-6 97.91%
Nolatrexed
Nolatrexed is a thymidylate synthase inhibitor with potential anticancer activity.
T6603 Nelarabine 121032-29-9 97.90%
Nelarabine
Nelarabine (GW 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.
T2069 TH287 1609960-30-6 97.73%
TH287
TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.
T6856 Halofuginone 55837-20-2 97.67%
Halofuginone
Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml ...
T13969 Xanthopterin (hydrate) 5979-01-1 97.66%
Xanthopterin (hydrate)
Xanthopterin Hydrate is isolated from butterfly wings and could replace folic acid in the nutrition of many animal species.
T36757 DMT-dU-CE Phosphoramidite 109389-30-2 97.58%
DMT-dU-CE Phosphoramidite
DMT-dU-CE Phosphoramidite is a nucleoside molecule commonly used for the synthesis and sequencing of DNA.
TN1016 Kukoamine A 75288-96-9 97.45%
Kukoamine A
Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidative...
T0681 Rifampicin 13292-46-1 97.36%
Rifampicin
Rifampicin (Rifamycin AMP) is an antibacterial drug of the class of rifamycin.
T16911 Sorivudine 77181-69-2 97.33%
Sorivudine
Sorivudine (BV-araU) has antiviral activity against several viruses including varicella zoster virus, herpes simplex type 1 virus, and Epstein-Barr virus by inte...
T1982 3-AP 143621-35-6 97.33%
3-AP
3-AP (Triapine) is a novel inhibitor of the M2 subunit of ribonucleotide reductase (RR).
T4457 Pyridostatin Trihydrochloride T4457 97.3%
Pyridostatin Trihydrochloride
Pyridostatin Trihydrochloride (RR-82 Trihydrochloride) is a G-quadruplexe stabilizer, with a Kd of 490 nM.
T10104 3,4-Dihydroxybenzylamine hydrobromide 16290-26-9 97.28%
3,4-Dihydroxybenzylamine hydrobromide
3,4-Dihydroxybenzylamine hydrobromide (NSC-263475 hydrobromide) inhibits DNA polymerase activity in melanoma cells and displays growth inhibitory activity in mel...
T26396 6-Hydroxy-DOPA 21373-30-8 97.23%
6-Hydroxy-DOPA
6-Hydroxy-DOPA is an allosteric inhibitor of RAD52, it inhibits proliferation of BRCA-deficient cancer cells in vitro and also inhibits APE1.
T2627 Nolatrexed dihydrochloride 152946-68-4 97.02%
Nolatrexed dihydrochloride
Nolatrexed dihydrochloride (Thymitaq) is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activit...
TN2132 Quinizarin 81-64-1 97.02%
Quinizarin
Quinizarin (1,4-Dihydroxyanthraquinone) is a natural product
Procaine hydrochloride
T0802
Procaine hydrochloride (Novocaine HCl) is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties....
SL327
T2708
SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.
Thymidine
TWP2911
1. Thymidine (DThyd) overload due to Thymidine phosphorylase deficiency, and mitochondrial toxicity caused by antiviral Thymidine analogues.
POL1-IN-1
T4356
POL1-IN-1 (Compound 3A) can effectively inhibit the transcription of RNA polymerase I in the A375 malignant melanoma cell line but has no effect on polymerase II...
CeMMEC13
T6801
CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 μM).
Nolatrexed
T4228
Nolatrexed is a thymidylate synthase inhibitor with potential anticancer activity.
Nelarabine
T6603
Nelarabine (GW 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.
TH287
T2069
TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.
Halofuginone
T6856
Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml ...
Xanthopterin (hydrate)
T13969
Xanthopterin Hydrate is isolated from butterfly wings and could replace folic acid in the nutrition of many animal species.
DMT-dU-CE Phosphoramidite
T36757
DMT-dU-CE Phosphoramidite is a nucleoside molecule commonly used for the synthesis and sequencing of DNA.
Kukoamine A
TN1016
Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidative...
Rifampicin
T0681
Rifampicin (Rifamycin AMP) is an antibacterial drug of the class of rifamycin.
Sorivudine
T16911
Sorivudine (BV-araU) has antiviral activity against several viruses including varicella zoster virus, herpes simplex type 1 virus, and Epstein-Barr virus by inte...
3-AP
T1982
3-AP (Triapine) is a novel inhibitor of the M2 subunit of ribonucleotide reductase (RR).
Pyridostatin Trihydrochloride
T4457
Pyridostatin Trihydrochloride (RR-82 Trihydrochloride) is a G-quadruplexe stabilizer, with a Kd of 490 nM.
3,4-Dihydroxybenzylamine hydrobromide
T10104
3,4-Dihydroxybenzylamine hydrobromide (NSC-263475 hydrobromide) inhibits DNA polymerase activity in melanoma cells and displays growth inhibitory activity in mel...
6-Hydroxy-DOPA
T26396
6-Hydroxy-DOPA is an allosteric inhibitor of RAD52, it inhibits proliferation of BRCA-deficient cancer cells in vitro and also inhibits APE1.
Nolatrexed dihydrochloride
T2627
Nolatrexed dihydrochloride (Thymitaq) is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activit...
Quinizarin
TN2132
Quinizarin (1,4-Dihydroxyanthraquinone) is a natural product
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TargetMol