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DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.
Cat. No. Product name CAS No. Purity Chemical Structure
T23820 BRD32048 433694-46-3 98%
BRD32048 is the ETV1 transcription factor oncoprotein inhibitor.
T14864 Caracemide 81424-67-1 98%
Caracemide inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide can be used in anticancer studies.
T35455 N-Nitrosodiethylamine 55-18-5 98%
N-Nitrosodiethylamine is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in water, tobacco smoke, cheddar cheese, cured,...
T15235 Enocitabine 55726-47-1 98%
Enocitabine, a nucleoside analog, is a potent DNA replication inhibitor and a DNA chain terminator. Enocitabine inhibits the replication of human cytomegalovirus...
TN3967 Epieriocalyxin A 191545-24-1 98%
Epieriocalyxin A can suppress Caco-2 colon cancer cell growth, it could be a potential drug for colon cancer therapy in the future.
T14522 Beaucage reagent 66304-01-6 98%
Beaucage reagent, which is found to be effective in causing DNA cleavage.
T9656 AP-1/NF-κB activation inhibitor 1 188936-12-1 98%
AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation ( IC 50 =1 μM), does not blocking basal transcripti...
T1663 Deoxythymidine triphosphate 18423-43-3 98%
Deoxythymidine triphosphate (dTTP) is one of the four nucleoside triphosphates that are used in the in vivo synthesis of DNA.
T6823 E3330 136164-66-4 98%
E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.
T37101 1-Hydroxyanthraquinone 129-43-1 98%
1-Hydroxyanthraquinone is an anthraquinone that has been found inMorinda officinalisand has genotoxic and carcinogenic activities.1,21-Hydroxyanthraquinone (5 an...
T40661 ML-60218 577784-91-9 98%
ML-60218 is an inhibitor of broad-spectrum RNA pol III with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled vir...
TN1660 Ganoderic acid C1 95311-97-0 98%
Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic ac...
T38427 DUTP trisodium 102814-08-4 98%
dUTP trisodium is a deoxyuridine phosphate having a triphosphate group at the 5'-position and can be used for PCR.
T26396 6-Hydroxy-DOPA 21373-30-8 98%
6-Hydroxy-DL-DOPA is an allosteric inhibitor of RAD52, it inhibits proliferation of BRCA-deficient cancer cells in vitro and also inhibits APE1.
T40192 DGTP 2564-35-4 98%
dGTP is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
T9350 IMP-1088 2059148-82-0
IMP-1088 is a potent inhibitor of human N-myristoyltransferases NMT1 and NMT2 dual.
T6753 AI-10-49 1256094-72-0
AI-10-49 is a selective inhibitor of the binding of CBFβ-SMMHC to RUNX1 with IC50 of 260 nM.
T16757 Risdiplam 1825352-65-5
Risdiplam (RG7916) is orally administered. Risdiplam is a centrally and peripherally distributed SMN2 pre-mRNA splicing modifier which increases survival motor n...
T0220 Foscarnet sodium 63585-09-1
Foscarnet sodium is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
T5363 Tempo 2564-83-2
TEMPO has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin reson...
BRD32048
T23820
BRD32048 is the ETV1 transcription factor oncoprotein inhibitor.
Caracemide
T14864
Caracemide inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide can be used in anticancer studies.
N-Nitrosodiethylamine
T35455
N-Nitrosodiethylamine is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in water, tobacco smoke, cheddar cheese, cured,...
Enocitabine
T15235
Enocitabine, a nucleoside analog, is a potent DNA replication inhibitor and a DNA chain terminator. Enocitabine inhibits the replication of human cytomegalovirus...
Epieriocalyxin A
TN3967
Epieriocalyxin A can suppress Caco-2 colon cancer cell growth, it could be a potential drug for colon cancer therapy in the future.
Beaucage reagent
T14522
Beaucage reagent, which is found to be effective in causing DNA cleavage.
AP-1/NF-κB activation inhibitor 1
T9656
AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation ( IC 50 =1 μM), does not blocking basal transcripti...
Deoxythymidine triphosphate
T1663
Deoxythymidine triphosphate (dTTP) is one of the four nucleoside triphosphates that are used in the in vivo synthesis of DNA.
E3330
T6823
E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.
1-Hydroxyanthraquinone
T37101
1-Hydroxyanthraquinone is an anthraquinone that has been found inMorinda officinalisand has genotoxic and carcinogenic activities.1,21-Hydroxyanthraquinone (5 an...
ML-60218
T40661
ML-60218 is an inhibitor of broad-spectrum RNA pol III with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled vir...
Ganoderic acid C1
TN1660
Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic ac...
dUTP trisodium
T38427
dUTP trisodium is a deoxyuridine phosphate having a triphosphate group at the 5'-position and can be used for PCR.
6-Hydroxy-DOPA
T26396
6-Hydroxy-DL-DOPA is an allosteric inhibitor of RAD52, it inhibits proliferation of BRCA-deficient cancer cells in vitro and also inhibits APE1.
dGTP
T40192
dGTP is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
IMP-1088
T9350
IMP-1088 is a potent inhibitor of human N-myristoyltransferases NMT1 and NMT2 dual.
AI-10-49
T6753
AI-10-49 is a selective inhibitor of the binding of CBFβ-SMMHC to RUNX1 with IC50 of 260 nM.
Risdiplam
T16757
Risdiplam (RG7916) is orally administered. Risdiplam is a centrally and peripherally distributed SMN2 pre-mRNA splicing modifier which increases survival motor n...
Foscarnet sodium
T0220
Foscarnet sodium is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
Tempo
T5363
TEMPO has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin reson...
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