DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.

Cat. No.	Product name	CAS No.	Purity
T23820	BRD32048	433694-46-3	98%
T23820	BRD32048 is the ETV1 transcription factor oncoprotein inhibitor.
T14864	Caracemide	81424-67-1	98%
T14864	Caracemide inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide can be used in anticancer studies.
T35455	N-Nitrosodiethylamine	55-18-5	98%
T35455	N-Nitrosodiethylamine is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in water, tobacco smoke, cheddar cheese, cured,...
T15235	Enocitabine	55726-47-1	98%
T15235	Enocitabine, a nucleoside analog, is a potent DNA replication inhibitor and a DNA chain terminator. Enocitabine inhibits the replication of human cytomegalovirus...
TN3967	Epieriocalyxin A	191545-24-1	98%
TN3967	Epieriocalyxin A can suppress Caco-2 colon cancer cell growth, it could be a potential drug for colon cancer therapy in the future.
T14522	Beaucage reagent	66304-01-6	98%
T14522	Beaucage reagent, which is found to be effective in causing DNA cleavage.
T9656	AP-1/NF-κB activation inhibitor 1	188936-12-1	98%
T9656	AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation ( IC 50 =1 μM), does not blocking basal transcripti...
T1663	Deoxythymidine triphosphate	18423-43-3	98%
T1663	Deoxythymidine triphosphate (dTTP) is one of the four nucleoside triphosphates that are used in the in vivo synthesis of DNA.
T6823	E3330	136164-66-4	98%
T6823	E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.
T37101	1-Hydroxyanthraquinone	129-43-1	98%
T37101	1-Hydroxyanthraquinone is an anthraquinone that has been found inMorinda officinalisand has genotoxic and carcinogenic activities.1,21-Hydroxyanthraquinone (5 an...
T40661	ML-60218	577784-91-9	98%
T40661	ML-60218 is an inhibitor of broad-spectrum RNA pol III with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled vir...
TN1660	Ganoderic acid C1	95311-97-0	98%
TN1660	Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic ac...
T38427	DUTP trisodium	102814-08-4	98%
T38427	dUTP trisodium is a deoxyuridine phosphate having a triphosphate group at the 5'-position and can be used for PCR.
T26396	6-Hydroxy-DOPA	21373-30-8	98%
T26396	6-Hydroxy-DL-DOPA is an allosteric inhibitor of RAD52, it inhibits proliferation of BRCA-deficient cancer cells in vitro and also inhibits APE1.
T40192	DGTP	2564-35-4	98%
T40192	dGTP is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
T9350	IMP-1088	2059148-82-0
T9350	IMP-1088 is a potent inhibitor of human N-myristoyltransferases NMT1 and NMT2 dual.
T6753	AI-10-49	1256094-72-0
T6753	AI-10-49 is a selective inhibitor of the binding of CBFβ-SMMHC to RUNX1 with IC50 of 260 nM.
T16757	Risdiplam	1825352-65-5
T16757	Risdiplam (RG7916) is orally administered. Risdiplam is a centrally and peripherally distributed SMN2 pre-mRNA splicing modifier which increases survival motor n...
T0220	Foscarnet sodium	63585-09-1
T0220	Foscarnet sodium is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
T5363	Tempo	2564-83-2
T5363	TEMPO has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin reson...