DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.

Cat. No.	Product name	CAS No.	Purity
T1058	Carboplatin	41575-94-4	99.72%
T1058	Carboplatin (JM-8) is a cisplatin derivative, a DNA synthesis inhibitor. Carboplatin binds to DNA, inhibits replication and transcription, and induces cell death...
T4517	L189	64232-83-3	99.72%
T4517	L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).
T23820	BRD32048	433694-46-3	99.69%
T23820	BRD32048 is the ETV1 transcription factor oncoprotein inhibitor.
T0415	Guanidine hydrochloride	50-01-1	99.68%
T0415	Guanidine hydrochloride (Aminoformamidine Hydrochloride) is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the ur...
T9051	ZYN57939	1639357-93-9	99.68%
T9051	ZYN57939 (MTR-106) is RNA polymerase I inhibitor for treating RNA polymerase I- mediated diseases. ZYN57939 showed inhibitory activity with IC50 of 0.855 μM agai...
T15282	Filibuvir	877130-28-4	99.68%
T15282	Filibuvir (PF-00868554) is a selective and noncovalent inhibitor of HCV NS5B RNA-dependent RNA polymerase. Filibuvir inhibits genotype 1a and 1b replicons with E...
T0251	Gemcitabine	95058-81-4	99.67%
T0251	Gemcitabine (LY188011) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. G...
T14501	BAY-2402234	2225819-06-5	99.67%
T14501	BAY-2402234 is an inhibitor of dihydroorotate dehydrogenase (DHODH) for the treatment of myeloid malignancies.BAY 2402234 is a selective low-nanomolar inhibitor ...
T7174	Urolithin A	1143-70-0	99.66%
T7174	Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
T1276	Danofloxacin mesylate	119478-55-6	99.66%
T1276	Danofloxacin mesylate (CP 76136-27) is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase.
T8873	Bractoppin	2290527-07-8	99.65%
T8873	Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrat...
T72107	Werner syndrome RecQ helicase-IN-1	2869954-34-5	99.62%
T72107	Werner syndrome RecQ helicase-IN-1 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach ...
T1272L	Cytarabine hydrochloride	69-74-9	99.62%
T1272L	Cytarabine hydrochloride (Ara-C hydrochloride) is a nucleoside analog that causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA ...
T2276	RI-1	415713-60-9	99.62%
T2276	RI-1 (RAD51 inhibitor 1) is a RAD51 inhibitor (IC50: 5-30 μM).
T67509	Cholesteryl Hemisuccinate	1510-21-0	99.61%
T67509	Cholesteryl Hemisuccinate (Cholesterol hydrogen succinate) is a highly soluble cholesterol analogue often used in polar solutions for its hepatoprotective, antic...
T1564	Cisplatin	15663-27-1	99.6%
T1564	Cisplatin (CDDP) is a DNA cross-linking agent. Cisplatin has antitumor activity and inhibits DNA synthesis by forming DNA adducts in cancer cells. Cisplatin also...
T40823	NCGC00029283	714240-31-0	99.6%
T40823	NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μM....
T8800	NSAH	1099592-35-4	99.59%
T8800	NSAH (2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide) is a nonnucleoside inhibitor of human ribonucleotide reductase (hRR).with cell-free...
T1663	Deoxythymidine triphosphate	18423-43-3	99.59%
T1663	Deoxythymidine triphosphate (dTTP) is one of the four nucleoside triphosphates that are used in the in vivo synthesis of DNA.
T2601	Vidofludimus	717824-30-1	99.58%
T2601	Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).