DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.

Cat. No.	Product name	CAS No.	Purity
T1646	Famciclovir	104227-87-4	99.58%
T1646	Famciclovir (BRL 42810) is a Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor. The mechanism of action of famciclovir is as a DNA Polymerase Inhib...
T2037	TH588	1609960-31-7	99.57%
T2037	TH588 is nudix hydrolase family inhibitor that effectively and selectively engages and inhibits the MTH1(IC50: 5 nM) in cells.
T27583	IDD388	314297-26-2	99.56%
T27583	IDD388 is a selective and potent aldose reductase (ALR2) inhibitor with antitumor activity that inhibits the ALR1 receptor.
T1511	Daunorubicin hydrochloride	23541-50-6	99.53%
T1511	Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein s...
T5270	5-Methylcytosine	554-01-8	99.53%
T5270	5-Methylcytosine is a methylated nucleotide base found in eukaryotic DNA. In animals, the DNA methylation of cytosine to form 5-methylcytosine is found primarily...
T27112	Cytembena	21739-91-3	99.53%
T27112	Cytembena is a cytostatic and a carcinogenic compound that may increase the incidence of fibroadenomas.Cytembena broadly inhibits DNA biosynthesis.
T1408	Capecitabine	154361-50-9	99.53%
T1408	Capecitabine (Capecitibine) is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is...
T1349	5-Fluorouridine	316-46-1	99.53%
T1349	5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to t...
T6225	Adenine hydrochloride	2922-28-3	99.53%
T6225	Adenine hydrochloride (6-Aminopurine hydrochloride) is a hydrochloride salt form of adenine which is a nucleobase with a variety of roles in biochemistry.
TQ0063	Zoliflodacin	1620458-09-4	99.51%
TQ0063	Zoliflodacin (ETX0914) (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against ...
T19836	2-Aminopurine	452-06-2	99.51%
T19836	2-Aminopurine is a double-stranded RNA-dependent protein kinase, protein kinase R (PKR) inhibitor.
T2069L	TH287 hydrochloride	1638211-05-8	99.5%
T2069L	TH287 is a selective MTH1 inhibitor(IC50 : 0.8 nM). It causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeut...
T3400	Bakuchiol	10309-37-2	99.47%
T3400	Bakuchiol possesses anti-tumor,and anti-helmenthic properties. It has cytotoxic activity, mainly due to its DNA polymerase1 inhibiting activity. Bakuchiol has an...
T1767	BMH-21	896705-16-1	99.47%
T1767	BMH-21, a small molecule DNA intercalator, binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and not affects phosphorylation of H2AX.
T1485	Methotrexate	59-05-2	99.46%
T1485	Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive act...
T6746	6-Thio-2'-Deoxyguanosine	789-61-7	99.44%
T6746	6-Thio-2'-Deoxyguanosine (β-TGdR) is a nucleoside analog and telomerase substrate.
T7655	Fialuridine	69123-98-4	99.43%
T7655	Fialuridine (DRG-0098) is a DNA-directed DNA polymerase inhibitor potentially for the treatment of HBV infection with potent activity against hepatitis B virus i...
T16757	Risdiplam	1825352-65-5	99.43%
T16757	Risdiplam (RO7034067) (RG7916) is orally administered. Risdiplam is a centrally and peripherally distributed SMN2 pre-mRNA splicing modifier which increases surv...
T1617	Enrofloxacin	93106-60-6	99.43%
T1617	Enrofloxacin (BAY-Vp2674) is a veterinary antibacterial agent, used in poultry.
T2504	Pritelivir	348086-71-5	99.42%
T2504	Pritelivir (BAY 57-1293) (BAY 57-1293) is a potent helicase-primase inhibitor with active against HSV-1 and HSV-2 (IC50: 20 nM).