T13271 |
USP7-IN-6
|
2166586-47-4
|
98%
|
|
USP7-IN-6 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 6.8 nM).
|
T12926 |
SJB3-019A
|
2070015-29-9
|
98%
|
|
SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 times mor...
|
T67876 |
USP8-IN-2
|
2477651-11-7
|
98%
|
|
USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D. USP8-IN-2 is a potential compound for the tr...
|
T13269 |
USP7-IN-3
|
2202738-42-7
|
98%
|
|
USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).
|
T61575 |
USP15-IN-1
|
2260826-16-0
|
98%
|
|
USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM). USP15-IN-1 showed high antiproliferative activity against non-small cell lung cancer and leukemia cells...
|
T12621L |
FT671
|
1959551-26-8
|
98%
|
|
FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).
|
T15351 |
FT827
|
1959537-86-0
|
98%
|
|
FT827 is a selective and covalent inhibitor of ubiquitin-specific protease 7 (USP7) (Ki: 4.2 µM). FT827 binds to the USP7 catalytic domain (apparent Kd: 7.8 µM)....
|
T13270 |
USP7-IN-5
|
2166599-74-0
|
98%
|
|
USP7-IN-5 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 49.9 nM).
|
T37591 |
IMP-1710
|
2383117-96-0
|
98%
|
|
IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.
|
T67873 |
USP8-IN-3
|
2477651-10-6
|
98%
|
|
USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D. USP8-IN-3 inhibited the proliferation of GH3 an...
|
T15729 |
LDN-91946
|
439946-22-2
|
98%
|
|
LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).
|
T21527 |
HBX 41108
|
924296-39-9
|
98%
|
|
HBx 41108 is a non-competitive, reversible inhibitor of USP7 with an IC50 of 424nM. HBx 41108 inhibited deubiquitination of p53 mediated by USP7 in a dose-depend...
|
T36682 |
USP30 inhibitor 18
|
2242582-40-5
|
98%
|
|
USP30 inhibitor 18 is a selective USP30 inhibitor with an IC50 of 0.02 μM. USP30 inhibitor 18 increases protein ubiquitination and accelerates mitophagy[1].
[1]....
|
T11112 |
DUB-IN-3
|
924296-17-3
|
|
|
DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c. The IC50 for USP8 is 0.56 μM.
|
T3089 |
6-Thioguanine
|
154-42-7
|
100%
|
|
Thioguanine is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
|
T4634 |
GNE-6776
|
2009273-71-4
|
96.59%
|
|
GNE-6776 is a selective USP7 inhibitor.
|
T14852 |
C527
|
192718-06-2
|
97.64%
|
|
C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).
|
T3088 |
N-Ethylmaleimide
|
128-53-0
|
98%
|
|
N-ethylmaleimide is a sulfhydryl reagent that is widely used in experimental biochemical studies.
|
T1932 |
B-AP15
|
1009817-63-3
|
98%
|
|
B-AP15(NSC687852) is a selective inhibitor of the deubiquitinating enzymes Usp14 and UCHL5 of the 26S proteasome. It blocks the deubiquitinating activity of the ...
|
T1937 |
Spautin-1
|
1262888-28-7
|
98%
|
|
Spautin-1 is a novel autophagy inhibitor, IM inhibited the growth of K562 cells with IC50 of 1.03 μM. In contrast, co-treatment with Spautin-1 increased IM-induc...
|