T4338 |
USP7/USP47 inhibitor
|
1247825-37-1
|
98%
|
|
USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively.
|
T11110 |
DUB-IN-1
|
924296-18-4
|
98%
|
|
DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).
|
T11111 |
DUB-IN-2
|
924296-19-5
|
98%
|
|
Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.
|
T13268 |
USP7-IN-1
|
1381291-36-6
|
98%
|
|
USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 77 μM) and used for cancer.
|
T3089 |
6-Thioguanine
|
154-42-7
|
98%
|
|
Thioguanine is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
|
T9122 |
XL177A
|
2417089-74-6
|
98%
|
|
XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.
|
T15464 |
HBX 19818
|
1426944-49-1
|
98%
|
|
HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).
|
T67876 |
USP8-IN-2
|
2477651-11-7
|
98%
|
|
USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D. USP8-IN-2 is a potential compound for the tr...
|
T1937 |
Spautin-1
|
1262888-28-7
|
98%
|
|
Spautin-1 is a novel autophagy inhibitor, IM inhibited the growth of K562 cells with IC50 of 1.03 μM. In contrast, co-treatment with Spautin-1 increased IM-induc...
|
T36682 |
USP30 inhibitor 18
|
2242582-40-5
|
98%
|
|
USP30 inhibitor 18 is a selective USP30 inhibitor with an IC50 of 0.02 μM. USP30 inhibitor 18 increases protein ubiquitination and accelerates mitophagy[1].
[1]....
|
T6107 |
IU1
|
314245-33-5
|
98%
|
|
IU1(IC50=4.7 μ M), a reversible, specific human USP14 proteasome inhibitor, can penetrate the cell.
|
T21527 |
HBX 41108
|
924296-39-9
|
98%
|
|
HBx 41108 is a non-competitive, reversible inhibitor of USP7 with an IC50 of 424nM. HBx 41108 inhibited deubiquitination of p53 mediated by USP7 in a dose-depend...
|
T67873 |
USP8-IN-3
|
2477651-10-6
|
98%
|
|
USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D. USP8-IN-3 inhibited the proliferation of GH3 an...
|
T8464 |
RA-9
|
919091-63-7
|
98%
|
|
RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs), with favorable toxicity profile and anticancer activity. RA-9 ...
|
T11112 |
DUB-IN-3
|
924296-17-3
|
98%
|
|
DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c. The IC50 for USP8 is 0.56 μM.
|
T7678 |
SJB2-043
|
63388-44-3
|
98%
|
|
SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).
|
T6697 |
TCID
|
30675-13-9
|
98%
|
|
TCID(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.
|
T60130 |
USP5-IN-1
|
|
98%
|
|
USP5-IN-1 (compound 64) is a potent deubiquitinase USP5 inhibitor, which binds to the USP5 ZnF-UBD with a KD of 2.8 μM and is selective over nine proteins contai...
|
T15604 |
IU1-47
|
670270-31-2
|
98%
|
|
IU1-47 is an effective and specific USP14 inhibitor (IC50: 0.6 μM). IU1-47 causes tau elimination in cultured neurons. IU1-47 inhibits IsoT/USP5 (IC50: 20 μM).
|
T5461 |
GNE-6640
|
2009273-67-8
|
98%
|
|
GNE-6640 is a non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for full length USP7, US...
|