EGFR

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.

Cat. No.	Product name	CAS No.	Purity
T14138	AG-825	149092-50-2	98.43%
T14138	AG-825（Tyrphostin C15） is a selective and competitive ErbB2 inhibitor that inhibits tyrosine phosphorylation with an IC50 value of 0.35 μM.AG-825 (Tyrphostin C15...
T3545	RG13022	136831-48-6	98.38%
T3545	RG13022 (Tyrphostin RG13022) is a tyrosine kinase inhibitor; inhibits the autophosphorylation reaction of the EGF receptor (IC50: 4 μM).
T2327	Pelitinib	257933-82-7	98.37%
T2327	Pelitinib (EKB-569) (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).
T6092	Sapitinib	848942-61-0	98.35%
T6092	Sapitinib (AZD-8931) , a reversible, ATP competitive inhibitor of EGFR(IC50=4 nM), ErbB2(IC50=3 nM) and ErbB3(IC50=4 nM), is more effective over Gefitinib or Lap...
T11569	HKI-357	848133-17-5	98.31%
T11569	HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 (IC50s: 34 nM and 33 nM). HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK ph...
T10965	DBPR112	1226549-49-0	98.29%
T10965	DBPR112 is an orally active furanopyrimidine-based EGFR inhibitor with IC50s of 15 nM and 48 nM for EGFRWT and EGFRL858R/T790M, respectively. DBPR112 can occupy ...
T22272	Lifirafenib	1446090-79-4	98.25%
T22272	Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant BRAFV600E...
T30855	CGP77675	234772-64-6	98.23%
T30855	CGP77675 (ZINC1488120) is a potent and selective inhibitor of Src family kinase with IC50s of 5-20 and 40 nM for the phosphorylation of peptide substrates and au...
T2518	ARRY-380 (analog )	937265-83-3	98.22%
T2518	ARRY-380 analog (HER2-Inhibitor-1) is a potent and selective HER2 inhibitor.
T4183	Lavendustin A	125697-92-9	98.17%
T4183	lavendustin A (RG-14355) is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.
T11160	EGFR-IN-5	2225887-26-1	98.17%
T11160	EGFR-IN-5 is a selective inhibitor of EGFR. The IC50s for EGFR, EGFR(L858R), EGFR(L858R/T790M), and EGFR(L858R/T790M/C797S) are 10.4, 1.1, 34, 7.2 nM, respective...
T2642	PD173074	219580-11-7	98.15%
T2642	PD173074 is an effective FGFR1 inhibitor (IC50: 25 nM) and also inhibits VEGFR2 (IC50: 100-200 nM) in cell-free assays. The selectivity is higher ~1000-fold for ...
T12777	RTC-5	1423077-49-9	98.14%
T12777	RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties. It exhibits considerable effectiveness ag...
T6238	WZ4002	1213269-23-8	98.12%
T6238	WZ4002 is a mutant-selective EGFR inhibitor for EGFR(L858R) and EGFR(T790M) with IC50 of 2 nM/8 nM.
T17182	TX1-85-1	1603845-32-4	98.12%
T17182	TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling. TX1-85-1 is an irreversible Her3 inhibitor (IC50: 23 nM). TX1-85-1 ...
T64124	Sunvozertinib	2370013-12-8	98.11%
T64124	Sunvozertinib (DZD9008) is a potent ErbBs and BTK inhibitor and has inhibitory effects on EGFR, Her2 and mutant epidermal growth factor. Sunvozertinib showed inh...
T63732	EGFR-IN-3		98.1%
T63732	EGFR-IN-3 is an EGFR inhibitor with potential antitumour activity.EGFR-IN-3 inhibits EGFRwt-TK and induces apoptosis (cell death), which can cause cells to block...
T21954	EGFR/ErbB-2/ErbB-4 inhibitor-2	179248-61-4	98.1%
T21954	EGFR/ErbB-2/ErbB-4 inhibitor-2 (EGFR/ErbB2 Inhibitor) is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively)
T12594	Pyrotinib dimaleate	1397922-61-0	98.07%
T12594	Pyrotinib dimaleate (SHR-1258 dimaleate) is a potent and selective dual inhibitor of EGFR/HER2 with IC50s of 13 and 38 nM, respectively.
T19965	Dacomitinib hydrate	1042385-75-0	98.05%
T19965	Dacomitinib hydrate (PF 299804) is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of tyrosi...