EGFR

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.

Cat. No.	Product name	CAS No.	Purity	Chemical Structure
T79152	PROTAC EGFR degrader 8	2925923-46-0	98%
T79152	PROTAC EGFR degrader 8 (T-184) is a PROTAC that selectively degrades the epidermal growth factor receptor (EGFR) with a DC50 of 15.56 nM in HCC827 cells. It effe...
T79293	EGFR-IN-79		98%
T79293	EGFR-IN-79 (compound 21), an EGFR inhibitor, exhibits antitumor activity through ROS-independent apoptosis and EGFR/AKT/mTOR-mediated autophagy. It effectively i...
T79297	DZD1516	2387570-00-3	98%
T79297	DZD1516, a potent and selective HER2 inhibitor (IC50 = 0.56 nM), demonstrates good blood-brain barrier permeability and exhibits antitumor activity in both centr...
T79327	EGFR-IN-81		98%
T79327	EGFR-IN-81 (Compound 10i), an EGFR inhibitor, demonstrates potent activity by inhibiting EGFR WT and the L858R/T790M mutation at IC50 values of 4.38 nM and 5.69 ...
T79368	Antiproliferative agent-34	2910858-34-1	98%
T79368	Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT. Addit...
T79386	EGFR-IN-84		98%
T79386	EGFR-IN-84 (Compound 6g), an EGFR inhibitor with an IC50 of 24 nM, impedes the growth of A549 cells with an IC50 value of 1.537 μM and is utilized for lung cance...
T79392	ALK/EGFR-IN-1	2730430-08-5	98%
T79392	ALK/EGFR-IN-1 (Compound 8l) is a dual inhibitor targeting both ALK and EGFR, effectively blocking their phosphorylation. It demonstrates potent inhibition of ALK...
T79461	YK-029A	2064269-82-3	98%
T79461	YK-029A, an orally active EGFR mutant inhibitor, targets both EGFR T790M and EGFRex20ins mutations. It demonstrates notable antitumor efficacy, inducing tumor re...
T79572	MAPK-IN-2		98%
T79572	MAPK-IN-2 (compound 3h) is an efficacious MAPK inhibitor with antineoplastic properties that significantly hinders proliferation across various cancer cell lines...
T79651	EGFR-IN-83		98%
T79651	EGFR-IN-83 (Compound 9), an EGFR inhibitor with an IC50 of 2.53 nM, exhibits antiproliferative effects on MCF-7 and MDA-MB-231 cell lines, with respective IC50 v...
T79694	EGFR-IN-88	2944452-34-8	98%
T79694	EGFR-IN-88 (Compound 4i), an EGFR inhibitor with an IC50 of 87 nM, exhibits cytotoxic effects on A549 cells at an IC50 of 3.902 μM and can induce cell apoptosis ...
T79727	EGFR/CDK2-IN-2		98%
T79727	EGFR/CDK2-IN-2 (compound 6a) serves as a dual inhibitor targeting both EGFR and CDK-2, exhibiting IC50 values of 19.6 nM and 87.9 nM, respectively. It promotes a...
T79728	EGFR/CDK2-IN-3		98%
T79728	EGFR/CDK2-IN-3 (compound 4b) serves as a dual inhibitor targeting both EGFR and CDK-2, exhibiting IC50 values of 71.7 nM and 113.7 nM, respectively. It prompts a...
T79729	EGFR/CDK2-IN-4		98%
T79729	EGFR/CDK2-IN-4 (compound 4c) is a dual inhibitor targeting EGFR and CDK-2, demonstrating IC50 values of 89.6 nM for EGFR and 165.4 nM for CDK-2. It prompts apopt...
T79775	EGFR-IN-89	2413029-40-8	98%
T79775	EGFR-IN-89 (compound 13k) is a fourth-generation inhibitor selectively targeting EGFR mutations, exhibiting potent activity with an IC50 of 10.1 nM against Del19...
T79888	EGFR-IN-87	1835666-87-9	98%
T79888	EGFR-IN-87 is an EGFR tyrosine kinase inhibitor with potent inhibitory activity, exhibiting IC50 values of 3.1 nM, 1.3 nM, and 7.1 nM against EGFR_d746-750, EGFR...
T80206	Oligopeptide-41		98%
T80206	Oligopeptide-41 is a bioactive peptide known for its hair growth-promoting effects and is reported to be used as an ingredient in cosmetics [1].
T80220	OK2		98%
T80220	OK2, a specific inhibitor of the CCN2/EGFR interaction, effectively disrupts this interaction by binding to the CT domain of CCN2. It holds potential for use in ...
T80574	Becotatug	2648260-93-7	98%	Becotatug
T80574	Becotatug (JMT-101) is an IgG1 antibody that targets EGFR and can be conjugated to Afatinib and Osimertinib, functioning as a synthetic antibody-drug conjugate (...			Becotatug
T80590	Cinrebafusp alfa	2218515-90-1	98%	Cinrebafusp alfa
T80590	Cinrebafusp alfa (PRS 343) is an anticalin-based bispecific drug with high affinity for both CD137/HER2, displaying dissociation constants (Kd) of 0.3 nM to reco...			Cinrebafusp alfa