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EGFR

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.

Cat. No.	Product name	CAS No.	Purity	Chemical Structure
T19489	O-Desmethyl gefitinib D8	T19489	98%
T19489	O-Desmethyl gefitinib D8 is a deuterium labeled O-Desmethyl gefitinib that is an active metabolite of Gefitinib in human plasma.
T73128	EGFR-IN-61	2890261-81-9	98%
T73128	EGFR-IN-61 (compound 22a), a potent EGFR kinase inhibitor, exhibits IC50 values of 42 nM for L858R/T790M, 137 nM for L858R/T790M/C797S, and 743 nM for WT. Additi...
T73165	EGFR-IN-73	2857033-34-0	98%
T73165	EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, exhibiting an IC50 value of 119 nM [1].
T73995	EGFR/CSC-IN-1	2820447-02-5	98%
T73995	EGFR/CSC-IN-1 is a dual inhibitor targeting both the epidermal growth factor receptor (EGFR [IC50 10.52 nM]) and cancer stem cells (CSC), with potential applicat...
T10556	BKI-1369	1951431-22-3	98%
T10556	BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).
T10433	Osimertinib dimesylate	2070014-82-1	98%
T10433	Osimertinib dimesylate is an irreversible and mutant selective EGFR inhibitor (IC50s: 12 and 1 nM against EGFR L858R and EGFR L858R/T790M).
T11213L	Epertinib	908305-13-5	98%
T11213L	Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM). It displays a strong antitumor ...
TN3711	Corylifol C	775351-91-2	98%
TN3711	Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor...
T16362	Nuvenzepine	96487-37-5	98%
T16362	Nuvenzepine is an antagonist of mAChR. It has the potential for gastrospasm treatment.
TN5100	Taspine	602-07-3	98%
TN5100	Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of H...
TN4213	Hirsutenone	41137-87-5	98%
TN4213	Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
T12131	Mutated EGFR-IN-3	2375107-27-8	98%
T12131	Mutated EGFR-IN-3 is a ATP-competitive and highly selective allosteric dibenzodiazepinone EGFR(L858R/T790M) and EGFR(L858R/T790M/C797S) inhibitor(IC50 of 12 nM a...
T13743	JH-XI-10-02	2209085-22-1	98%
T13743	JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. JH-XI-10-02 is a potent and selective degrade...
TN1912	Marinobufogenin	470-42-8	98%
TN1912	Marinobufagenin, a cardiotonic steroid, its increased concentrations are important in the cardiac disease and oxidant stress state seen with renal failure.
T9922	Matuzumab	339186-68-4	98%	Matuzumab
T9922	Matuzumab is a humanized monoclonal antibody used in cancer treatment. It has a high affinity for EGFR frequently associated with the growth of blood vessels in ...			Matuzumab
TN2504	1,5-Dihydroxyxanthone	14686-65-8	98%
TN2504	1,5-Dihydroxyxanthone exhibits the epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitory activity, with the IC50 value of 90.34 nM. It may have ant...
T12130	Mutated EGFR-IN-2	2050906-97-1	98%
T12130	Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.
T11159	EGFR-IN-2	1643497-70-4	98%
T11159	EGFR-IN-2 is a non-covalent, mutation-selective and irreversible second-generation EGFR inhibitor.
T8525	EGFR-IN-16	133550-22-8	98%
T8525	EGFR-IN-16 (AG473) is an inhibitor of EGFR in human A431 cells.
TN4638	Neolinine	112515-37-4	98%
TN4638	Neolinine(at 10uM) shows significant hERG K+ channel inhibition activity.