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EGFR

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.

Cat. No.	Product name	CAS No.	Purity
T2490	Osimertinib	1421373-65-0	99.83%
T2490	Osimertinib (AZD-9291) is an EGFR third-generation inhibitor that inhibits the T790M resistance mutation produced by second-generation EGFR inhibitors with irrev...
T2106	WS6	1421227-53-3	99.83%
T2106	WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
T6196	PP1	172889-26-8	99.82%
T6196	PP1 (AGL 1872), a specific and effective Src inhibitor, is with IC50 for Lck/Fyn is 5 nM/ 6 nM, respectively.
T15621	Rilematovir	1383450-81-4	99.82%
T15621	Rilematovir (JNJ-678) is an inhibitor of fusion protein with antiviral activity and low cytotoxicity. Rilematovir can be used in studies about respiratory syncyt...
T2851	Daphnetin	486-35-1	99.82%
T2851	Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), an...
T2280	Endoxifen (Z-isomer)	112093-28-4	99.81%
T2280	Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase ac...
T7175	Alflutinib mesylate	2130958-55-1	99.81%
T7175	Alflutinib mesylate (AST2818 mesylate) ,is an irreversible tyrosine kinase inhibitor that selectively inhibits EGFR mutations, especially T790M.
T11157L	EGFR-IN-1 hydrochloride	2227455-78-7	99.8%
T11157L	EGFR-IN-1 hydrochloride is an irreversible and specific inhibitor of L858R/T790M mutant EGFR with 100-fold selectivity over wild-type EGFR. EGFR-IN-1 hydrochlori...
T6153	Icotinib	610798-31-7	99.79%
T6153	Icotinib (Conmana) is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity.
T2307	Icotinib Hydrochloride	1204313-51-8	99.77%
T2307	Icotinib Hydrochloride (BPI-2009H) is the hydrochloride salt form of icotinib, an orally available quinazoline-based inhibitor of EGFR, with potential antineopla...
T79851	Labuxtinib	1426449-01-5	99.77%
T79851	Labutinib is a selective inhibitor of the c-kit tyrosine kinase [1].
T3721	Avitinib maleate	1557268-88-8	99.77%
T3721	Avitinib maleate is a pyrrolopyrimidine-based irreversible epidermal growth factor receptor (EGFR) inhibitor.
T12542	Rilzabrutinib	1575596-29-0	99.76%
T12542	Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).
T4528	Tyrphostin AG 528	133550-49-9	99.74%
T4528	Tyrphostin AG 528 (Tyrphostin B66) is an inhibitor of EGFR (IC50: 4.9 μM) and ErbB2 (IC50: 2.1 μM).
T6824	EAI045	1942114-09-1	99.73%
T6824	EAI045, an allosteric inhibitor, targets towards drug-resistant EGFR mutants but avoids the wild-type receptor.
T16162	Mutated EGFR-IN-1	1421372-66-8	99.73%
T16162	Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant...
T2446	KI8751	228559-41-9	99.73%
T2446	KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.
T8151	Mobocertinib	1847461-43-1	99.72%
T8151	Mobocertinib (tak788) is a potent inhibitor of epidermal growth factor receptor (EGFR) and an antineoplastic agent
T6235	Lapatinib Ditosylate	388082-77-7	99.71%
T6235	Lapatinib Ditosylate (Tykerb ditosylate) is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).
T2995	Chrysophanol	481-74-3	99.7%
T2995	Chrysophanol (Turkey Rhubarb) is an EGFR/mTOR pathway inhibitor, which can be found in rhubarb, and sorrel.