T2035 |
WHI-P258
|
21561-09-1
|
99.59%
|
|
WHI-P258 is a dimethoxyquinazoline inhibitor of JAK3. This compound binds JAK3 weakly and may be used as a JAK-binding negative control in the development of new...
|
T3554 |
RG14620
|
136831-49-7
|
99.56%
|
|
RG14620 (Tyrphostin RG14620) is an epidermal growth factor receptor (EGFR) inhibitor.
|
T6227 |
Benidipine hydrochloride
|
91599-74-5
|
99.56%
|
|
Benidipine hydrochloride (Coniel) , a hydrochloride salt form of benidipine, is used as a blocker of dihydropyridine calcium channel.
|
T10782 |
CGP52411
|
145915-58-8
|
99.56%
|
|
CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM). CGP52411 blocks the toxic influx of Ca2+ ions into neuronal cells and dramati...
|
T0373L |
Erlotinib hydrochloride
|
183319-69-9
|
99.52%
|
|
Erlotinib hydrochloride (NSC 718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.
|
T22431 |
SU5204
|
186611-11-0
|
99.5%
|
|
SU5204 (3-[(2-Ethoxyphenyl)methylidene]-1H-indol-2-one), an analogue of SU5025, pharmacologically inhibits VEGFR2(IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) and ...
|
T1431 |
Khellin
|
82-02-0
|
99.49%
|
|
Khellin (Methafrone) is a vasodilator that also has bronchodilatory action.
|
T11163 |
EGFR-IN-9
|
1226549-39-8
|
99.46%
|
|
EGFR-IN-9 is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M). EGFR-IN-9 has an...
|
T5475 |
ZD-4190
|
413599-62-9
|
99.42%
|
|
ZD-4190 is a inhibitor of the vascular endothelial cell growth factor receptor 2 (VEGFR2) and of epidermal growth factor receptor (EGFR) signalling, used for the...
|
T39275 |
Befotertinib
|
1835667-63-4
|
99.40%
|
|
Befotertinib (D-0316) is an inhibitor of EGFR tyrosine kinase and can be used for studies about EGFR T790M-positive non-small cell lung cancer.
|
T2600 |
AG490
|
133550-30-8
|
99.39%
|
|
AG490 (Tyrphostin B42) is an inhibitor of EGFR (IC50: 0.1 μM). It is 135-fold more selective for EGFR than ErbB2, also inhibits JAK2 with no effect to Lyn, Lck, ...
|
T16343 |
NRC-2694
|
936446-61-6
|
99.38%
|
|
NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.
|
T11158 |
EGFR-IN-11
|
2463200-44-2
|
99.37%
|
|
EGFR-IN-11 is a selective inhibitor of EGFR-tyrosine kinase and induces cell apoptosis. EGFR-IN-11 inhibits triple mutant EGFRL858R/T790M/C797S with an IC50 of 1...
|
T11213 |
Epertinib hydrochloride
|
2071195-74-7
|
99.36%
|
|
Epertinib hydrochloride (S-22611 hydrochloride) shows potent antitumor activity. Epertinib hydrochloride is a potent, orally active, reversible, and selective ty...
|
T2479 |
Tyrphostin A9
|
10537-47-0
|
99.36%
|
|
Tyrphostin A9 (SF 6847) is an Agricultural acaricide, now superseded. Tyrphostin A9 is firstly designed as an EGFR inhibitor
|
T2483 |
Dacomitinib
|
1110813-31-4
|
99.34%
|
|
Dacomitinib (PF299)(PF299804; PF-00299804) is a highly selective, orally bioavailable small-molecule inhibitor of the HER family of tyrosine kinases with IC50 of...
|
T0129 |
Sanguinarine chloride
|
5578-73-4
|
99.33%
|
|
Sanguinarine chloride (Pseudochelerythrine chloride), a benzophenanthridine alkaloid, stimulates apoptosis by activating the production of reactive oxygen specie...
|
T2041 |
PD153035
|
153436-54-5
|
99.31%
|
|
PD153035 (NSC-669364) hydrochloride is an effective and selective inhibitor of EGFR (Ki/IC50: 5.2/29 pM, in cell-free assays); little inhibitory against FGFR, PG...
|
T23127 |
PD-161570
|
192705-80-9
|
99.23%
|
|
PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c...
|
T2501 |
Canertinib dihydrochloride
|
289499-45-2
|
99.23%
|
|
Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiose...
|