EGFR

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.

Cat. No.	Product name	CAS No.	Purity
T1991	ZM323881 hydrochloride	193000-39-4	99.5%
T1991	ZM323881 hydrochloride (ZM 323881 HCl) is a potent and selective VEGFR2 inhibitor.
T1431	Khellin	82-02-0	99.49%
T1431	Khellin (Methafrone) is a vasodilator that also has bronchodilatory action.
T11163	EGFR-IN-9	1226549-39-8	99.46%
T11163	EGFR-IN-9 is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M). EGFR-IN-9 has an...
T5475	ZD-4190	413599-62-9	99.42%
T5475	ZD-4190 is a compound that inhibits both the vascular endothelial growth factor receptor 2 (VEGFR2) and the epidermal growth factor receptor (EGFR) signaling pat...
T4249	AZD3759 hydrochloride	1626387-81-2	99.41%
T4249	AZD3759 (hydrochloride) is an effective, orally active and central nervous system-penetrant EGFR inhibitor. At Km ATP concentrations, the IC50s are 0.2/0.3/0.2 n...
T39275	Befotertinib	1835667-63-4	99.40%
T39275	Befotertinib (D-0316) is an inhibitor of EGFR tyrosine kinase and can be used for studies about EGFR T790M-positive non-small cell lung cancer.
T16343	NRC-2694	936446-61-6	99.38%
T16343	NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.
T11158	EGFR-IN-11	2463200-44-2	99.37%
T11158	EGFR-IN-11 is a selective inhibitor of EGFR-tyrosine kinase and induces cell apoptosis. EGFR-IN-11 inhibits triple mutant EGFRL858R/T790M/C797S with an IC50 of 1...
T11213	Epertinib hydrochloride	2071195-74-7	99.36%
T11213	Epertinib hydrochloride (S-22611 hydrochloride) shows potent antitumor activity. Epertinib hydrochloride is a potent, orally active, reversible, and selective ty...
T2479	Tyrphostin A9	10537-47-0	99.36%
T2479	Tyrphostin A9 (SF 6847) is an Agricultural acaricide, now superseded. Tyrphostin A9 is firstly designed as an EGFR inhibitor
T2483	Dacomitinib	1110813-31-4	99.34%
T2483	Dacomitinib (PF299)(PF299804; PF-00299804) is a highly selective, orally bioavailable small-molecule inhibitor of the HER family of tyrosine kinases with IC50 of...
T0129	Sanguinarine chloride	5578-73-4	99.33%
T0129	Sanguinarine chloride (Pseudochelerythrine chloride), a benzophenanthridine alkaloid, stimulates apoptosis by activating the production of reactive oxygen specie...
T2041	PD153035	153436-54-5	99.31%
T2041	PD153035 (NSC-669364) hydrochloride is an effective and selective inhibitor of EGFR (Ki/IC50: 5.2/29 pM, in cell-free assays); little inhibitory against FGFR, PG...
T23127	PD-161570	192705-80-9	99.23%
T23127	PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c...
T2501	Canertinib dihydrochloride	289499-45-2	99.23%
T2501	Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiose...
TL0016	Sulforaphene	592-95-0	99.19%
TL0016	Sulforaphene is a natural product isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10 -4 M. Sulforaphene promotes canc...
T10802	CHMFL-EGFR-202	2089381-40-6	99.19%
T10802	CHMFL-EGFR-202 is a potent, irreversible inhibitor of EGFR mutant kinase (IC50s: 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases).
T2063	Tyrphostin 23	118409-57-7	99.19%
T2063	Tyrphostin 23 (AG18) inhibits EGFR with IC50 of 35 μM.
T1985	WHI-P154	211555-04-3	99.19%
T1985	WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.
T16996	TAS6417	1661854-97-2	99.19%
T16996	TAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC (IC50: ranging from 1.1-8.0 nM).