ERK

ERK is a downstream component of an evolutionarily conserved signaling module that is activated by the Raf serine/threonine kinases. Raf activates the MAPK/ERK kinase (MEK)1/2 dual-specificity protein kinases, which then activate ERK1/2.

Cat. No.	Product name	CAS No.	Purity
T6947	Piperlongumine	20069-09-4	99.89%
T6947	Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L. It selectively kills cancer cells and strengthens the level of reactive oxygen species (RO...
T5S0168	Atractylenolide II	73069-14-4	99.89%
T5S0168	1. Atractylenolide II (2-Atractylenolide) has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p...
T7005	Ulixertinib	869886-67-9	99.89%
T7005	Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.
T3001	Honokiol	35354-74-6	99.87%
T3001	Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.
T6511	Ravoxertinib	1453848-26-4	99.87%
T6511	Ravoxertinib (GDC-0994) is an effective and orally available ERK1/2 inhibitor (IC50: 1.1/0.3 nM).
T2416	BIX02189	1094614-85-3	99.86%
T2416	BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.
TN2346	Mogrol	88930-15-8	99.85%
TN2346	Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling.
T5727	CAFESTOL	469-83-0	99.84%
T5727	CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells....
T10479	BAY885	2307249-33-6	99.83%
T10479	BAY885 is a new ERK5 inhibitor.
T1144	Lidocaine hydrochloride	73-78-9	99.83%
T1144	Lidocaine hydrochloride (Lignocaine hydrochloride) is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and...
T62929	RLX-33	2784577-71-3	99.82%
T62929	RLX-33 is a potent and selective antagonist of relaxin family peptide 3 (RXFP3) that crosses the blood-brain barrier and also blocks relaxin 3-induced ERK1/2 pho...
TN3609	Catalposide	6736-85-2	99.82%
TN3609	Catalposide is a potent inducer of (HO)-1 isolated from Catalpa ovate G. Don (Bignoniaceae). Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, a...
TN1441	Beta-Tocopherol	148-03-8	99.81%
TN1441	Beta-Tocopherol shows effect on human erythroleukemia cell (HEL) adhesion induced by phorbol 12-myristate 13-acetate (PMA).
T21588	Olomoucine	101622-51-9	99.8%
T21588	Olomoucine is an ATP competitive inhibitor of Cdk2/cyclin A, Cdc2/CyclinB, CDK2/CyclinE, CDK5/p35, and ERK1/p44 MAP kinase with IC50s of 7, 7, 7, 3 and 25 µM, re...
T1956	FR 180204	865362-74-9	99.8%
T1956	FR 180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2.
TN1786	Isomerazin	1088-17-1	99.8%
TN1786	Isomerazin (Isomeranzin) has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, NF-κB and ERK pathw...
T3844	Deltonin	55659-75-1	99.79%
T3844	Deltonin has an inhibition of ERK1/2 and AKT activation. Deltonin shows cytotoxicity against human HepG2 cells (IC50: 7.66 μM), mouse C26 cells (IC50: 1.22 μM), ...
T6993	Tauroursodeoxycholate sodium	35807-85-3	99.78%
T6993	Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.
T77734	ERK5-IN-5	2318792-30-0	99.77%
T77734	ERK5-IN-5 is a potent extracellular signal-regulated kinase 5 (ERK5) inhibitor with anticancer activity and potential anticonvulsant activity that inhibits A549 ...
T1842	XMD17-109	1435488-37-1	99.75%
T1842	XMD17-109 (ERK5-IN-1) is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells).