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ERK

ERK is a downstream component of an evolutionarily conserved signaling module that is activated by the Raf serine/threonine kinases. Raf activates the MAPK/ERK kinase (MEK)1/2 dual-specificity protein kinases, which then activate ERK1/2.

Cat. No.	Product name	CAS No.	Purity
T2961	Notoginsenoside R1	80418-24-2	99.57%
T2961	Notoginsenoside R1 (Sanchinoside R1) has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.
T6139L	A-674563 2HCl(552325-73-2(fb-2hcl))	T6139L	99.57%
T6139L	A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
T2029	Bohemine	189232-42-6	99.53%
T2029	Bohemine is a cyclin-dependent kinase inhibitor.
T3856	Tenuifoliside A	139726-35-5	99.49%
T3856	Tenuifoliside A has anti-apoptotic , neuroprotective activity. And tenuifoliside A has anti-inflammatory effect, which is mediated by the inhibition of the NF-κB...
T1956	FR 180204	865362-74-9	99.49%
T1956	FR 180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2.
TN1922	Meranzin hydrate	5875-49-0	99.49%
TN1922	Meranzin hydrate exhibits antidepressive and prokinetic-like effects through the regulation of the common mediator, the alpha 2-adrenoceptor , and α±-amino-3-hyd...
TN1410	Asperulosidic acid	25368-11-0	99.47%
TN1410	Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-...
T6S0117	Avicularin	572-30-5	99.43%
T6S0117	Avicularin (Fenicularin) has anti-allergic, anti-inflammatory, hepatoprotective, antioxidant, anti-tumor and other activities. It ameliorates human hepatocellula...
T5184	ERK5-IN-1	1234479-76-5	99.42%
T5184	ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).
T8472	ERK1/2 inhibitor 2	2095719-92-7	99.29%
T8472	ERK1/2 inhibitor 2 (ASTX029) is a selective and orally bioavailable extracellular signal-regulated kinases 1 and 2 (ERK 1/2) inhibitor, with potential antineopla...
T10429	Tizaterkib	2097416-76-5	99.24%
T10429	Tizaterkib (AZD-0364) is a potent and selective ERK2 inhibitor.
TN1996	Nothofagin	11023-94-2	99.21%
TN1996	Nothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of CAMs, and adhes...
T6139	A-674563	552325-73-2	99.21%
T6139	A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
T6324	(E/Z)-BIX02188	1094614-84-2	99.21%
T6324	BIX02188 is a specific MEK5 inhibitor (IC50: 4.3 nM), also inhibits ERK5 catalytic activity (IC50: 810 nM), and does not inhibit closely related kinases MEK1/2, ...
T12058	MK2-IN-3 hydrate	1186648-22-5	99.14%
T12058	MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)
T14894	CC-90003	1621999-82-3	99.14%
T14894	CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.
T11226	ERK1/2 inhibitor 1	2095719-90-5	99.09%
T11226	ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.
T67748	ROCK-IN-5	692870-25-0	99.03%
T67748	ROCK-IN-5 (compound I-B-37) is a potent inhibitor of protein kinases, including ROCK, ERK, GSK, and AGC. ROCK-IN-5 exhibits the potential for cardiac, proliferat...
T14360	AX-15836	2035509-96-5	99.03%
T14360	AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).
T4518	Licochalcone D	144506-15-0	99.03%
T4518	Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking ce...