ERK

ERK is a downstream component of an evolutionarily conserved signaling module that is activated by the Raf serine/threonine kinases. Raf activates the MAPK/ERK kinase (MEK)1/2 dual-specificity protein kinases, which then activate ERK1/2.

Cat. No.	Product name	CAS No.	Purity
TN1560	Dehydroeffusol	137319-34-7	99.35%
TN1560	Dehydroeffusol (Dehydro Effusol) possesses anti-cancer, anxiolytic and sedative properties. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity...
T8472	ERK1/2 inhibitor 2	2095719-92-7	99.29%
T8472	ERK1/2 inhibitor 2 (ASTX029) is a selective and orally bioavailable extracellular signal-regulated kinases 1 and 2 (ERK 1/2) inhibitor, with potential antineopla...
T10429	Tizaterkib	2097416-76-5	99.24%
T10429	Tizaterkib (AZD-0364) is a potent and selective ERK2 inhibitor.
TN1996	Nothofagin	11023-94-2	99.21%
TN1996	Nothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of CAMs, and adhes...
T6139	A-674563	552325-73-2	99.21%
T6139	A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
T6324	(E/Z)-BIX02188	1094614-84-2	99.21%
T6324	BIX02188 is a specific MEK5 inhibitor (IC50: 4.3 nM), also inhibits ERK5 catalytic activity (IC50: 810 nM), and does not inhibit closely related kinases MEK1/2, ...
TL0016	Sulforaphene	592-95-0	99.19%
TL0016	Sulforaphene is a natural product isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10 -4 M. Sulforaphene promotes canc...
T12058	MK2-IN-3 hydrate	1186648-22-5	99.14%
T12058	MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)
T14894	CC-90003	1621999-82-3	99.14%
T14894	CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.
T11226	ERK1/2 inhibitor 1	2095719-90-5	99.09%
T11226	ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.
T67748	ROCK-IN-5	692870-25-0	99.03%
T67748	ROCK-IN-5 (compound I-B-37) is a potent inhibitor of protein kinases, including ROCK, ERK, GSK, and AGC. ROCK-IN-5 exhibits the potential for cardiac, proliferat...
T14360	AX-15836	2035509-96-5	99.03%
T14360	AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).
T5S2361	Epiberberine	6873-09-2	98.95%
T5S2361	1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/...
T5S0761	Nitidine chloride	13063-04-2	98.91%
T5S0761	1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721...
T3S2344	β,β-Dimethylacrylshikonin	24502-79-2	98.86%
T3S2344	1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of D...
T2973	Astragaloside IV	84687-43-4	98.85%
T2973	Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metall...
TN2179	Saponarin	20310-89-8	98.84%
TN2179	Saponarin (Petrocomoside) shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage.
T10827	CK2/ERK8-IN-1	1085822-09-8	98.82%
T10827	CK2/ERK8-IN-1 (TMCB) is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds t...
TN1459	Bufarenogin	17008-65-0	98.77%
TN1459	Bufarenogin (3beta,12beta,14-Trihydroxy-11-oxo-5beta-bufa-20,22-dienolide) is a bufadienolide isolated from parotoid gland secretions of the Cuban endemic toad P...
T72662	NMDAR/TRPM4-IN-2	2243506-33-2	98.77%
T72662	NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retina...