ERK

ERK is a downstream component of an evolutionarily conserved signaling module that is activated by the Raf serine/threonine kinases. Raf activates the MAPK/ERK kinase (MEK)1/2 dual-specificity protein kinases, which then activate ERK1/2.

Cat. No.	Product name	CAS No.	Purity
T4S0878	Prunetin	552-59-0	98%
T4S0878	1. Prunetin (Prunusetin) significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin media...
T4S2063	Tetrahydrocoptisine	4312-32-7	98%
T4S2063	1. Tetrahydrocoptisine (STYLOPINE) has effective effects in suppressing inflammation. 2. Tetrahydrocoptisine possesses a protective effect on LPS-induced ALI thr...
T5364	TBHQ	1948-33-0	98%
T5364	TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.
T5535	ERK5-IN-2	1888305-96-1	98%
T5535	ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.
T60777	EM127	1886879-71-5	97.61%
T60777	EM127 is a highly selective and potent covalent inhibitor of SMYD3 with a KD value of 13 μM.EM127 inhibits ERK1/2 phosphorylation and inhibits transcriptional re...
TMA2474	δ-Tocotrienol	25612-59-3	97.38%
TMA2474	δ-Tocotrienol (Delta-Tocotrienol) is a potential angiogenic inhibitor. δ-Tocotrienol is also a nontoxic activator of mir-34a which can inhibit nonsmall cell lung...
TQ0005	KO-947	1695533-89-1	96.81%
TQ0005	KO-947 is a potent and specific inhibitor of ERK1/2 kinases.
TP1970L	Prosaptide TX14(A) acetate	TP1970L	95.29%
TP1970L	Prosaptide TX14(A) acetate is a potent GPR37L1 and GPR37 agonist. Prosaptide Tx14(A) TFA increases both ERK1 and ERK2 phosphorylation in Schwann cells.
TN4114	Gardenin A	21187-73-5	95.15%
TN4114	Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.
T6S1572	Sauchinone	177931-17-8	100%
T6S1572	1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation o...
T4S2326	Cornuside	131189-57-6	100%
T4S2326	1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in t...
T0304	Methylthiouracil	56-04-2	100%
T0304	Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.
T6818	DEL-22379	181223-80-3	100%
T6818	DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ～0.5 μM.
T3S0209	Vincristine	57-22-7	100%
T3S0209	Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-...
T3857	Magnolin	31008-18-1
T3857	Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. Magnolin has anti-inflammatory a...
T1933	NVP 231	362003-83-6
T1933	NVP-231 is a potent, specific and reversible CerK inhibitor(IC50=12±2 nM) that competitively inhibits ceramide binding to CerK.
T2356	Ro-3306	872573-93-8
T2356	RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases...
TN3967	Epieriocalyxin A	191545-24-1
TN3967	Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.
T3668	Galangin	548-83-4
T3668	Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.
T6948	Pluripotin	839707-37-8
T6948	Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGA...