Endothelin Receptor

There are at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC, all of which are G protein-coupled receptors whose activation result in elevation of intracellular-free calcium, which constricts the smooth muscles of the blood vessels, raising blood pressure, or relaxes the smooth muscles of the blood vessels, lowering blood pressure, among other functions.

Cat. No.	Product name	CAS No.	Purity	Chemical Structure
T78096	BQ-3020 ammonium		98%
T78096	BQ-3020 ammonium, a selective endothelin receptor (ET B receptor) agonist, demonstrates inhibition of [125 I] ET-1 binding to ET B receptors with an IC50 of 0.2 ...
T80438	Atrial natriuretic peptide (3-28) (human)	102686-43-1	98%
T80438	Atrial natriuretic peptide (3-28) (human) (ANP (3-28) (human)), a peptide hormone produced by the atrial myocardium, plays a critical role in the regulation of b...
T81538	Patecibart	2642374-04-5	98%	Patecibart
T81538	Patecibart is a humanized immunoglobulin G4-kappa monoclonal antibody that functions as an antagonist to the endothelin receptor A (EDNRA).			Patecibart
TN4606	Myriceric acid C	162059-94-1	98%
TN4606	Myriceric acid C has cytotoxic activity against human lung carcinoma and breast carcinoma.
T11934	Macitentan-d4	1258428-05-5	98%
T11934	Macitentan-d4 (ACT-064992 D4) is a deuterated substitute for Macitentan and can be used as a dual antagonist of the non-peptides ETA and ETB (endothelin receptor...
T0750	Sulfisoxazole	127-69-5	99.98%
T0750	Sulfisoxazole (Sulfafurazole) is a short-acting sulfonamide antibacterial with activity against a wide range of gram-negative and gram-positive organisms.Sulfiso...
T1655	Ambrisentan	177036-94-1	99.85%
T1655	Ambrisentan (BSF 208075) is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with ...
T2561	Macitentan	441798-33-0	99.81%
T2561	Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).
T6265	Bosentan (hydrate)	157212-55-0	99.75%
T6265	Bosentan hydrate (Ro 47-0203) is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.
TQ0282	Avosentan	290815-26-8	99.47%
TQ0282	Avosentan (Ro 67-0565) is an effective and selective antagonist of the endothelin receptor (ETA receptor).
T14219	Aminaftone	14748-94-8	99.39%
T14219	Aminaftone, a derivative of 4-aminobenzoic acid, inhibits endothelin-1 (ET-1) production and can be used to study hypertension and systemic sclerosis.
T12924	Sitaxsentan	184036-34-8	99.34%
T12924	Sitaxsentan (TBC-11251) is A selective endothelin A (ETA) receptor antagonist. Endothelin is an effective vasoconstrictor. Sitaxsentan blocks the binding of endo...
T6258	Zibotentan	186497-07-4	99.34%
T6258	Zibotentan (ZD4054) (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.
T34541	SB-209670	157659-79-5	99.24%
T34541	SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle.
T7817	Aprocitentan	1103522-45-7	99.17%
T7817	Aprocitentan (ACT-132577) is ETA and ETB antagonist .
TQ0259	Atrasentan	173937-91-2	99.08%
TQ0259	Atrasentan (ABT-627) (ABT-627) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
T5355	Sparsentan	254740-64-2	98.81%
T5355	Sparsentan (DARA-a) is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respective...
T3194	Ro 46-2005	150725-87-4	98.8%
T3194	Ro 46-2005 is a synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA recep...
T31605	Edonentan	210891-04-6	98.78%
T31605	Edonentan is A potent endothelin A (ETA) receptor antagonist that can be used to study heart failure.
T10595	BQ-788	173326-37-9	98.67%
T10595	BQ-788 is a selective and potent ETB receptor antagonist with potential hypertensive activity.BQ-788 inhibits ET-1 binding to ETB receptors and inhibits exogenou...