T39905 |
Legumain inhibitor 1
|
2361157-34-6
|
98.14%
|
|
Legumain inhibitor 1 is a highly potent and specific Legumain inhibitor with potential anticancer activity for cancer research.
|
T71534 |
CIA-1 hcl(452087-38-6 Free base)
|
1049691-47-5
|
98%
|
|
CIA-1 inhibits the nuclear receptor COUP-TFII, with IC50s ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines.CIA-1 inhibits the growth of a variety of p...
|
T14683 |
BMS-983970
|
1584713-87-0
|
98%
|
|
BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.
|
TP1540 |
Jagged-1 (188-204)
|
219127-21-6
|
98%
|
|
Jagged-1 (188-204)is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epi...
|
T11718 |
JI051
|
2234281-75-3
|
98%
|
|
JI051 is an antitumor agent that interacts with the cancer-associated protein chaperone prohibitin 2 (PHB2) to induce cell cycle arrest by inhibiting the transcr...
|
T14680 |
BMS-906024
|
1401066-79-2
|
99.87%
|
|
BMS-906024 (Osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule Notch inhibitor.BMS-906024 has broad-spectrum antitumour...
|
T15184 |
E 2012
|
870843-42-8
|
99.83%
|
|
E2012 is a γ-secretase modulator (GSM). E2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at ...
|
T6202 |
DAPT
|
208255-80-5
|
99.81%
|
|
DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active. DAPT is also a Notch inhibitor. DAPT induces ...
|
T16294 |
NGP555
|
1304630-27-0
|
99.77%
|
|
NGP555 is a modulator of γ-secretase.
|
T6935 |
Nirogacestat
|
1290543-63-3
|
99.77%
|
|
Nirogacestat (PF 03084014) is a specific γ-secretase inhibitor (IC50: 6.2 nM, in a cell-free assay).
|
T11358 |
Gamma-secretase modulator 1
|
1172637-87-4
|
99.75%
|
|
gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.
|
T11178L |
ELN318463 racemate
|
851599-82-1
|
99.73%
|
|
ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.
|
T22678 |
3,5-Bis(4-nitrophenoxy)benzoic acid
|
173550-33-9
|
99.71%
|
|
3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like pep...
|
T12246 |
CB-103
|
218457-67-1
|
99.69%
|
|
CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.
|
T62263 |
γ-Secretase modulator 13
|
1353570-40-7
|
99.68%
|
|
γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that inhibits the production of amyloid β-peptide Aβ42 and can be used to study Alzheimer's disease an...
|
T6135 |
YO-01027
|
209984-56-5
|
99.63%
|
|
YO-01027 (DBZ) is a potent γ-secretase inhibitor.
|
T6870 |
L-685458
|
292632-98-5
|
99.62%
|
|
L-685458 (L-685,458) is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
|
T9422 |
Fosciclopirox
|
1380539-06-9
|
99.60%
|
|
Fosciclopirox (CPX-POM), the phosphoryloxymethyl ester of CPX (Ciclopirox Prodrug, CPX-POM), selectively delivers the active metabolite, CPX, to the entire urina...
|
T4077 |
PE859
|
1402727-29-0
|
99.6%
|
|
PE859 is a potent inhibitor of both tau and Aβ aggregation.
|
T35566 |
RBPJ Inhibitor-1
|
2682114-39-0
|
99.58%
|
|
RBPJ Inhibitor-1 (RIN1) (RIN1), the RBPJ inhibitor, blocks the functional interaction of RBPJ with SHARP. RBPJ Inhibitor-1 (RIN1) inhibits NOTCH-dependent tumor ...
|