Gamma-secretase

Gamma secretase is a multi-subunit protease complex, itself an integral membrane protein, that cleaves single-pass transmembrane proteins at residues within the transmembrane domain. Proteases of this type are known as intramembrane proteases. The most well-known substrate of gamma secretase is amyloid precursor protein, a large integral membrane protein that, when cleaved by both gamma and beta secretase, produces a short 37-43[verification needed] amino acid peptide called amyloid beta whose abnormally folded fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. Gamma secretase is also critical in the related processing of several other type I integral membrane proteins, such as Notch, ErbB4, E-cadherin, N-cadherin, ephrin-B2, or CD44.

Cat. No.	Product name	CAS No.	Purity
T3521	γ-Secretase-IN-1	209986-17-4	99.56%
T3521	γ-Secretase-IN-1 is a potent γ-secretase inhibitor that displays partial antiproliferative activity on T-47D cells and inhibits β-amyloid(40), β-amyloid(42), and...
T7064	Valproic Acid	99-66-1	99.49%
T7064	Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be u...
TP1293	Jagged-1 (188-204) TFA(219127-21-6 free base)	TP1293	99.48%
TP1293	Jagged-1 (188-204) TFA(219127-21-6 free base) is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligan...
T2842	Tangeretin	481-53-8	99.37%
T2842	Tangeretin (NSC-618905), a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effect...
T63208	Aβ-IN-1	2766509-32-2	99.14%
T63208	Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM). Aβ-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells ...
T6125	Semagacestat	425386-60-3	99.11%
T6125	Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).
T4364	Aftin-4	866893-90-5	99.03%
T4364	Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin...
T1602	Valproic acid sodium salt	1069-66-5	99%
T1602	Valproic acid sodium salt (Sodium Valproate) is the sodium salt form of valproic acid with anti-epileptic activity. Valproic acid sodium salt is converted into i...
T2625	MK-0752	471905-41-6	98.99%
T2625	MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).
T9015	LY900009	209984-68-9	98.97%
T9015	LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.
T6249	Avagacestat	1146699-66-2	98.87%
T6249	Avagacestat (BMS-708163) (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonst...
TWS2045	Bruceine D	21499-66-1	98.81%
TWS2045	1. Bruceine D from Brucea javanica, may have the potential to be used as a natural viricide, or a lead compound for new viricides. 2. Bruceine D inhibits the gro...
T3633	Crenigacestat	1421438-81-4	98.76%
T3633	Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. Crenigacestat effectively inhib...
T13410	ZLDI-8	667880-38-8	98.09%
T13410	ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.
T2262	Itanapraced	749269-83-8	98%
T2262	Itanapraced (CHF5074), a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
T10532	BI-1408	2231075-94-6	97.91%
T10532	BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42).
T6274	RO4929097	847925-91-1	97.68%
T6274	RO4929097 (RG-4733), a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM).
T4S1990	Carvacrol	499-75-2	97.52%
T4S1990	1. Carvacrol (O-Thymol) presents anxiolytic effects. 2. 5-Isopropyl-2-methylphenol presents antinociceptive activity. 3. Carvacrol presents antidepressant effect...
T6063	LY-411575	209984-57-6	97.03%
T6063	LY-411575, a potent γ-secretase inhibitor, is with IC50 of 0.078 nM in the membrane and 0.082 nM in cell-based. It also suppresses Notch clevage with IC50 of 0.3...
T31987	Gossypolone	4547-72-2	96.66%
T31987	Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.