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GluR

Glutamate receptors are synaptic and non synaptic receptors located primarily on the membranes of neuronal and glial cells.Glutamate receptors are responsible for the glutamate-mediated postsynaptic excitation of neural cells, and are important for neural communication, memory formation, learning, and regulation.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T5509 FPTQ 864863-72-9 99.41%
FPTQ
FPTQ is a highly effective antagonist of mGluR 1, displaying IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively [1]. In addition to its robus...
T15090 Decoglurant 911115-16-7 99.39%
Decoglurant
Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3 and it also is developed as an antidepressant.
T5512 JNJ16259685 409345-29-5 99.39%
JNJ16259685
JNJ16259685 (TN.T 16259685) is a selective mGluR1 antagonist, and inhibits the synaptic activation of mGluR1 in a concentration-dependent manner with IC50 of 19 ...
T22641 CDPPB 781652-57-1 99.39%
CDPPB
CDPPB is a modulator of mGluR5 positive allosteric(with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5).
T12717 Basimglurant 802906-73-6 99.38%
Basimglurant
Basimglurant (CTEP Derivative) is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM).
T0326L L-Glutamine 56-85-9 99.36%
L-Glutamine
L-Glutamine (L-Glutamic acid 5-amide) , a non-essential amino acid, is synthesized from glutamic acid and ammonia.
T27854 LSN2463359 1401031-52-4 99.36%
LSN2463359
LSN2463359 is a positive allosteric modulators of the mGlu5 receptor.
T27947L LY339434 HCl 99.32%
LY339434 HCl
LY339434 HCl is a low affinity GluR5 erythrocyte receptor agonist.LY339434 HCl causes rapid neuronal death primarily by affecting N-methyl-D-aspartate (NMDA) rec...
T3464 PHCCC 179068-02-1 99.31%
PHCCC
PHCCC ((-) PHCCC) is a Group I metabotropic glutamate receptor antagonist and a positive allosteric modulator of mGluR4. It also is a potent to antagonism for mG...
T6598 MPEP 96206-92-7 99.31%
MPEP
MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.
T1884 CX516 154235-83-3 99.29%
CX516
CX516 (Ampalex), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, schizophrenia and mild c...
T5083 L-Cysteic acid monohydrate 23537-25-9 99.28%
L-Cysteic acid monohydrate
L-Cysteic acid monohydrate (3-Sulfo-L-alanine Monohydrate) is an oxidation product of L-cysteine that may be used as a competitive inhibitor of the bacterial asp...
T23008L MMPIP hydrochloride 1215566-78-1 99.26%
MMPIP hydrochloride
MMPIP hydrochloride is a selective antagonist of allosteric mGluR7. MMPIP hydrochloride can be used in research on the roles of mGluR7 on central nervous system ...
T16816 S 18986 175340-20-2 99.25%
S 18986
S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors, showcasing cognitive-enhancing properties in rodents...
T8457 NPS2390 226878-01-9 99.24%
NPS2390
NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively)
T23514 VU-1545 890764-63-3 99.24%
VU-1545
VU-1545 is mGlu5 positive allosteric modulator.
T12012 Methoxy-PEPy 524924-76-3 99.20%
Methoxy-PEPy
Methoxy-PEPy is a potent and selective mGlu5 receptor inhibitor with an IC50 value of 1 nM.
T23291 (S)-3-Hydroxyphenylglycine 71301-82-1 99.18%
(S)-3-Hydroxyphenylglycine
(S)-3-Hydroxyphenylglycine is an agonist of group I metabotropic glutamate receptors (mGluRs).
T2053 ADX-47273 851881-60-2 99.18%
ADX-47273
ADX-47273 (BA 94673139) is a positive and selective allosteric modulator for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM).
T3451 JNJ-42153605 1254977-87-1 99.13%
JNJ-42153605
JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM).
FPTQ
T5509
FPTQ is a highly effective antagonist of mGluR 1, displaying IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively [1]. In addition to its robus...
Decoglurant
T15090
Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3 and it also is developed as an antidepressant.
JNJ16259685
T5512
JNJ16259685 (TN.T 16259685) is a selective mGluR1 antagonist, and inhibits the synaptic activation of mGluR1 in a concentration-dependent manner with IC50 of 19 ...
CDPPB
T22641
CDPPB is a modulator of mGluR5 positive allosteric(with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5).
Basimglurant
T12717
Basimglurant (CTEP Derivative) is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM).
L-Glutamine
T0326L
L-Glutamine (L-Glutamic acid 5-amide) , a non-essential amino acid, is synthesized from glutamic acid and ammonia.
LSN2463359
T27854
LSN2463359 is a positive allosteric modulators of the mGlu5 receptor.
LY339434 HCl
T27947L
LY339434 HCl is a low affinity GluR5 erythrocyte receptor agonist.LY339434 HCl causes rapid neuronal death primarily by affecting N-methyl-D-aspartate (NMDA) rec...
PHCCC
T3464
PHCCC ((-) PHCCC) is a Group I metabotropic glutamate receptor antagonist and a positive allosteric modulator of mGluR4. It also is a potent to antagonism for mG...
MPEP
T6598
MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.
CX516
T1884
CX516 (Ampalex), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, schizophrenia and mild c...
L-Cysteic acid monohydrate
T5083
L-Cysteic acid monohydrate (3-Sulfo-L-alanine Monohydrate) is an oxidation product of L-cysteine that may be used as a competitive inhibitor of the bacterial asp...
MMPIP hydrochloride
T23008L
MMPIP hydrochloride is a selective antagonist of allosteric mGluR7. MMPIP hydrochloride can be used in research on the roles of mGluR7 on central nervous system ...
S 18986
T16816
S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors, showcasing cognitive-enhancing properties in rodents...
NPS2390
T8457
NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively)
VU-1545
T23514
VU-1545 is mGlu5 positive allosteric modulator.
Methoxy-PEPy
T12012
Methoxy-PEPy is a potent and selective mGlu5 receptor inhibitor with an IC50 value of 1 nM.
(S)-3-Hydroxyphenylglycine
T23291
(S)-3-Hydroxyphenylglycine is an agonist of group I metabotropic glutamate receptors (mGluRs).
ADX-47273
T2053
ADX-47273 (BA 94673139) is a positive and selective allosteric modulator for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM).
JNJ-42153605
T3451
JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM).
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TargetMol