T5509 |
FPTQ
|
864863-72-9
|
99.41%
|
|
FPTQ is a highly effective antagonist of mGluR 1, displaying IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively [1]. In addition to its robus...
|
T15090 |
Decoglurant
|
911115-16-7
|
99.39%
|
|
Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3 and it also is developed as an antidepressant.
|
T5512 |
JNJ16259685
|
409345-29-5
|
99.39%
|
|
JNJ16259685 (TN.T 16259685) is a selective mGluR1 antagonist, and inhibits the synaptic activation of mGluR1 in a concentration-dependent manner with IC50 of 19 ...
|
T22641 |
CDPPB
|
781652-57-1
|
99.39%
|
|
CDPPB is a modulator of mGluR5 positive allosteric(with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5).
|
T12717 |
Basimglurant
|
802906-73-6
|
99.38%
|
|
Basimglurant (CTEP Derivative) is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM).
|
T0326L |
L-Glutamine
|
56-85-9
|
99.36%
|
|
L-Glutamine (L-Glutamic acid 5-amide) , a non-essential amino acid, is synthesized from glutamic acid and ammonia.
|
T27854 |
LSN2463359
|
1401031-52-4
|
99.36%
|
|
LSN2463359 is a positive allosteric modulators of the mGlu5 receptor.
|
T27947L |
LY339434 HCl
|
|
99.32%
|
|
LY339434 HCl is a low affinity GluR5 erythrocyte receptor agonist.LY339434 HCl causes rapid neuronal death primarily by affecting N-methyl-D-aspartate (NMDA) rec...
|
T3464 |
PHCCC
|
179068-02-1
|
99.31%
|
|
PHCCC ((-) PHCCC) is a Group I metabotropic glutamate receptor antagonist and a positive allosteric modulator of mGluR4. It also is a potent to antagonism for mG...
|
T6598 |
MPEP
|
96206-92-7
|
99.31%
|
|
MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.
|
T1884 |
CX516
|
154235-83-3
|
99.29%
|
|
CX516 (Ampalex), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, schizophrenia and mild c...
|
T5083 |
L-Cysteic acid monohydrate
|
23537-25-9
|
99.28%
|
|
L-Cysteic acid monohydrate (3-Sulfo-L-alanine Monohydrate) is an oxidation product of L-cysteine that may be used as a competitive inhibitor of the bacterial asp...
|
T23008L |
MMPIP hydrochloride
|
1215566-78-1
|
99.26%
|
|
MMPIP hydrochloride is a selective antagonist of allosteric mGluR7. MMPIP hydrochloride can be used in research on the roles of mGluR7 on central nervous system ...
|
T16816 |
S 18986
|
175340-20-2
|
99.25%
|
|
S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors, showcasing cognitive-enhancing properties in rodents...
|
T8457 |
NPS2390
|
226878-01-9
|
99.24%
|
|
NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively)
|
T23514 |
VU-1545
|
890764-63-3
|
99.24%
|
|
VU-1545 is mGlu5 positive allosteric modulator.
|
T12012 |
Methoxy-PEPy
|
524924-76-3
|
99.20%
|
|
Methoxy-PEPy is a potent and selective mGlu5 receptor inhibitor with an IC50 value of 1 nM.
|
T23291 |
(S)-3-Hydroxyphenylglycine
|
71301-82-1
|
99.18%
|
|
(S)-3-Hydroxyphenylglycine is an agonist of group I metabotropic glutamate receptors (mGluRs).
|
T2053 |
ADX-47273
|
851881-60-2
|
99.18%
|
|
ADX-47273 (BA 94673139) is a positive and selective allosteric modulator for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM).
|
T3451 |
JNJ-42153605
|
1254977-87-1
|
99.13%
|
|
JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM).
|