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GluR

Glutamate receptors are synaptic and non synaptic receptors located primarily on the membranes of neuronal and glial cells.Glutamate receptors are responsible for the glutamate-mediated postsynaptic excitation of neural cells, and are important for neural communication, memory formation, learning, and regulation.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T21747 VU0483605 1623101-11-0 97.03%
VU0483605
VU0483605 is an effective and selective positive allosteric modulator of mGluR1 with EC50s of 390 and 356 nM for human and rat, respectively.
T27748L KRP-199 sodium 96.85%
KRP-199 sodium
KRP-199 sodium sodium is highly potent and selective for AMPA-R in vitro and exhibits good neuroprotection in vivo.
T16977 Talampanel 161832-65-1 95.54%
Talampanel
Talampanel (LY-300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity. Talampanel (IV...
T22730 DL-AP3 20263-06-3 95%
DL-AP3
DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase.
T3483 FTIDC 873551-53-2 94.58%
FTIDC
FTIDC is a highly potent and selective allosteric antagonist of mGluR1 receptors and shows very weak potency against human and rat mGluR5 receptors. The inhibiti...
T0313 Evans blue 314-13-6 85.86%
Evans blue
Evans blue (C.I. 23860) is an azo dye, inhibits L-glutamate uptake via the membrane-bound excitatory amino acid transporter (EAAT).
T2194 Direct Blue 1 2610-05-1 50%
Direct Blue 1
Direct Blue 1 (Pontamine sky blue), a counterstain for background autofluorescence in immunofluorescence histochemistry, structurally resembles glutamate and ope...
T15812 LY2979165 1311385-32-6 100.00%
LY2979165
LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.
T3565 VU0155041 1093757-42-6 100%
VU0155041
VU0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat).
T7823 IDRA-21 22503-72-6 100%
IDRA-21
IDRA-21 is a positive AMPA receptor modulator.
T10808 CHPG sodium salt 1303993-73-8 100%
CHPG sodium salt
CHPG sodium salt is a selective agonist of mGluR5 and activates the ERK and Akt signaling pathways. CHPG sodium salt can be used in studies about traumatic brain...
T60201 CX717 867276-98-0 100%
CX717
CX 717 is a positive allosteric modulator of AMPA receptor which has an antidepressant-like effect. CX 717 can be used for the research of adult attention defici...
T27932 LY-2300559 889115-58-6 100%
LY-2300559
LY-2300559 is an agonist of metabotropic glutamate receptor 2 (mGluR2) and can be used in studies about the treatment of migraine.
T6457 CTEP 871362-31-1 100%
CTEP
CTEP (RO 4956371) (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectiv...
T7706 LY-404187 211311-95-4 100%
LY-404187
LY404187 is a positive allosteric modulator of AMPA receptors
T6160 VU 0364439 1246086-78-1 100%
VU 0364439
VU 0364439 is a mGlu4 positive allosteric modulator (C50: 19.8 nM).
T22204 LY 2389575 hydrochloride 885104-09-6 100%
LY 2389575 hydrochloride
LY2389575 hydrochloride is an mGlu3 negative allosteric modulator (NAM) that is selective and non-competitive, with an IC50 value of 190 nM. LY2389575 hydrochlor...
T8435 YM90K 154164-30-4 100%
YM90K
YM90K (6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-) hydrochloride is an antagonist of AMPA receptor.
T13441 (R)-ADX-47273 851881-59-9
(R)-ADX-47273
(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator(EC50 of 168 nM for potentiation ).
T7494 TCN238 125404-04-8
TCN238
TCN238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM).
VU0483605
T21747
VU0483605 is an effective and selective positive allosteric modulator of mGluR1 with EC50s of 390 and 356 nM for human and rat, respectively.
KRP-199 sodium
T27748L
KRP-199 sodium sodium is highly potent and selective for AMPA-R in vitro and exhibits good neuroprotection in vivo.
Talampanel
T16977
Talampanel (LY-300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity. Talampanel (IV...
DL-AP3
T22730
DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase.
FTIDC
T3483
FTIDC is a highly potent and selective allosteric antagonist of mGluR1 receptors and shows very weak potency against human and rat mGluR5 receptors. The inhibiti...
Evans blue
T0313
Evans blue (C.I. 23860) is an azo dye, inhibits L-glutamate uptake via the membrane-bound excitatory amino acid transporter (EAAT).
Direct Blue 1
T2194
Direct Blue 1 (Pontamine sky blue), a counterstain for background autofluorescence in immunofluorescence histochemistry, structurally resembles glutamate and ope...
LY2979165
T15812
LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.
VU0155041
T3565
VU0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat).
IDRA-21
T7823
IDRA-21 is a positive AMPA receptor modulator.
CHPG sodium salt
T10808
CHPG sodium salt is a selective agonist of mGluR5 and activates the ERK and Akt signaling pathways. CHPG sodium salt can be used in studies about traumatic brain...
CX717
T60201
CX 717 is a positive allosteric modulator of AMPA receptor which has an antidepressant-like effect. CX 717 can be used for the research of adult attention defici...
LY-2300559
T27932
LY-2300559 is an agonist of metabotropic glutamate receptor 2 (mGluR2) and can be used in studies about the treatment of migraine.
CTEP
T6457
CTEP (RO 4956371) (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectiv...
LY-404187
T7706
LY404187 is a positive allosteric modulator of AMPA receptors
VU 0364439
T6160
VU 0364439 is a mGlu4 positive allosteric modulator (C50: 19.8 nM).
LY 2389575 hydrochloride
T22204
LY2389575 hydrochloride is an mGlu3 negative allosteric modulator (NAM) that is selective and non-competitive, with an IC50 value of 190 nM. LY2389575 hydrochlor...
YM90K
T8435
YM90K (6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-) hydrochloride is an antagonist of AMPA receptor.
(R)-ADX-47273
T13441
(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator(EC50 of 168 nM for potentiation ).
TCN238
T7494
TCN238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM).
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TargetMol