T21747 |
VU0483605
|
1623101-11-0
|
97.03%
|
|
VU0483605 is an effective and selective positive allosteric modulator of mGluR1 with EC50s of 390 and 356 nM for human and rat, respectively.
|
T27748L |
KRP-199 sodium
|
|
96.85%
|
|
KRP-199 sodium sodium is highly potent and selective for AMPA-R in vitro and exhibits good neuroprotection in vivo.
|
T16977 |
Talampanel
|
161832-65-1
|
95.54%
|
|
Talampanel (LY-300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity. Talampanel (IV...
|
T22730 |
DL-AP3
|
20263-06-3
|
95%
|
|
DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase.
|
T3483 |
FTIDC
|
873551-53-2
|
94.58%
|
|
FTIDC is a highly potent and selective allosteric antagonist of mGluR1 receptors and shows very weak potency against human and rat mGluR5 receptors. The inhibiti...
|
T0313 |
Evans blue
|
314-13-6
|
85.86%
|
|
Evans blue (C.I. 23860) is an azo dye, inhibits L-glutamate uptake via the membrane-bound excitatory amino acid transporter (EAAT).
|
T2194 |
Direct Blue 1
|
2610-05-1
|
50%
|
|
Direct Blue 1 (Pontamine sky blue), a counterstain for background autofluorescence in immunofluorescence histochemistry, structurally resembles glutamate and ope...
|
T15812 |
LY2979165
|
1311385-32-6
|
100.00%
|
|
LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.
|
T3565 |
VU0155041
|
1093757-42-6
|
100%
|
|
VU0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat).
|
T7823 |
IDRA-21
|
22503-72-6
|
100%
|
|
IDRA-21 is a positive AMPA receptor modulator.
|
T10808 |
CHPG sodium salt
|
1303993-73-8
|
100%
|
|
CHPG sodium salt is a selective agonist of mGluR5 and activates the ERK and Akt signaling pathways. CHPG sodium salt can be used in studies about traumatic brain...
|
T60201 |
CX717
|
867276-98-0
|
100%
|
|
CX 717 is a positive allosteric modulator of AMPA receptor which has an antidepressant-like effect. CX 717 can be used for the research of adult attention defici...
|
T27932 |
LY-2300559
|
889115-58-6
|
100%
|
|
LY-2300559 is an agonist of metabotropic glutamate receptor 2 (mGluR2) and can be used in studies about the treatment of migraine.
|
T6457 |
CTEP
|
871362-31-1
|
100%
|
|
CTEP (RO 4956371) (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectiv...
|
T7706 |
LY-404187
|
211311-95-4
|
100%
|
|
LY404187 is a positive allosteric modulator of AMPA receptors
|
T6160 |
VU 0364439
|
1246086-78-1
|
100%
|
|
VU 0364439 is a mGlu4 positive allosteric modulator (C50: 19.8 nM).
|
T22204 |
LY 2389575 hydrochloride
|
885104-09-6
|
100%
|
|
LY2389575 hydrochloride is an mGlu3 negative allosteric modulator (NAM) that is selective and non-competitive, with an IC50 value of 190 nM. LY2389575 hydrochlor...
|
T8435 |
YM90K
|
154164-30-4
|
100%
|
|
YM90K (6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-) hydrochloride is an antagonist of AMPA receptor.
|
T13441 |
(R)-ADX-47273
|
851881-59-9
|
|
|
(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator(EC50 of 168 nM for potentiation ).
|
T7494 |
TCN238
|
125404-04-8
|
|
|
TCN238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM).
|