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GluR

Glutamate receptors are synaptic and non synaptic receptors located primarily on the membranes of neuronal and glial cells.Glutamate receptors are responsible for the glutamate-mediated postsynaptic excitation of neural cells, and are important for neural communication, memory formation, learning, and regulation.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T22976 MFZ 10-7 1224431-15-5 98%
MFZ 10-7
MFZ 10-7 is anegative allosteric modulator of the mGluR5.
T23259 (RS)-3-Hydroxyphenylglycine 31932-87-3 98%
(RS)-3-Hydroxyphenylglycine
PI-linked metabotropic glutamate receptors agonist
T29135 VU0422288 1630936-95-6 98%
VU0422288
VU0422288 (ML396) is a potent orthosteric modulator of type III mGlu receptors (mGlus).VU0422288 shows inhibition of mGluR4, mGluR7, and mGluR8 in a calcium mobi...
T23303 S-Sulfo-L-cysteine sodium salt 7381-67-1 98%
S-Sulfo-L-cysteine sodium salt
S-Sulfo-L-cysteine sodium salt shows a weak affinity for mGluR1α and mGluR5a at high concentrations and has potential antioxidant activity.
T13321 VU6005649 2137047-43-7 98%
VU6005649
VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).
T41301 L-Cysteinesulfinic acid monohydrate 207121-48-0 98%
L-Cysteinesulfinic acid monohydrate
L-Cysteinesulfinic acid monohydrate is a potent agonist at rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mG...
T15456 GYKI 53655 hydrochloride 143692-48-2 98%
GYKI 53655 hydrochloride
GYKI 53655 hydrochloride (LY300168 hydrochloride) is an antagonist of AMPA and is used in the study of neurological disorders.
T3473 (S)-ATPO 252930-37-3 98%
(S)-ATPO
(S)-ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.
T22711 DCB 6971-97-7 98%
DCB
DCB (3,3'-dichlorobenzaldazine) is an allosteric ligand for mGluR5 and shows the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB). DCB blocks the...
T3479 (RS)-MCPG 146669-29-6 98%
(RS)-MCPG
(RS)-MCPG ((±)-MCPG) is a non-selective group I/II metabotropic glutamate receptor antagonist.
T1443 Memantine hydrochloride 41100-52-1 98%
Memantine hydrochloride
Memantine hydrochloride (Memantine HCl) is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparki...
T22840 HexylHIBO 334887-43-3 98%
HexylHIBO
HexylHIBO is a type I mGluR antagonist that inhibits mGlu1a and mGlu5a, with Kb values of 140 and 110 μM, respectively.HexylHIBO decreases sEPSC in rats.
T9133 Caroverine hydrochloride 55750-05-5 98%
Caroverine hydrochloride
Caroverine hydrochloride (Caroverine HCL) is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It is also an antioxidant and c...
T22638 CBiPES hydrochloride 856702-40-4 98%
CBiPES hydrochloride
CBiPES hydrochloride (CBiPES HCl) is a potent orthosteric modulator of the mGlu2 receptor with an EC50 value of 92.8 nM.CBiPES hydrochloride blocks the action of...
T6562 Latrepirdine dihydrochloride 97657-92-6 98%
Latrepirdine dihydrochloride
Latrepirdine dihydrochloride (Dimebolin dihydrochloride) is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors,...
T13323 VU6012962 2313526-86-0 98%
VU6012962
VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).
T20571 Cis-PDA 46026-75-9 98%
cis-PDA
cis-PDA (cis PDA) is a general ionotropic receptor antagonist. cis-PDA acts by blocking NMDA, AMPA, and kainate-mediated responses.
T20191 (-)-Camphoric acid 560-09-8 98%
(-)-Camphoric acid
(-)-Camphoric acid (L-Camphoric acid) is a less active enantiomer of Camphoric acid which induces GluR expression.
T9011 VU0155094 731006-86-3 98%
VU0155094
VU0155094 (ML 397) is a positive allosteric modulator with differential activity at the various group III mGluRs.
T15819 LY377604 204592-94-9 98%
LY377604
LY377604 is a human β3-adrenergic receptor agonist (EC50: 2.4 nM). It also a β1- and β2-adrenergic receptor antagonist.
MFZ 10-7
T22976
MFZ 10-7 is anegative allosteric modulator of the mGluR5.
(RS)-3-Hydroxyphenylglycine
T23259
PI-linked metabotropic glutamate receptors agonist
VU0422288
T29135
VU0422288 (ML396) is a potent orthosteric modulator of type III mGlu receptors (mGlus).VU0422288 shows inhibition of mGluR4, mGluR7, and mGluR8 in a calcium mobi...
S-Sulfo-L-cysteine sodium salt
T23303
S-Sulfo-L-cysteine sodium salt shows a weak affinity for mGluR1α and mGluR5a at high concentrations and has potential antioxidant activity.
VU6005649
T13321
VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).
L-Cysteinesulfinic acid monohydrate
T41301
L-Cysteinesulfinic acid monohydrate is a potent agonist at rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mG...
GYKI 53655 hydrochloride
T15456
GYKI 53655 hydrochloride (LY300168 hydrochloride) is an antagonist of AMPA and is used in the study of neurological disorders.
(S)-ATPO
T3473
(S)-ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.
DCB
T22711
DCB (3,3'-dichlorobenzaldazine) is an allosteric ligand for mGluR5 and shows the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB). DCB blocks the...
(RS)-MCPG
T3479
(RS)-MCPG ((±)-MCPG) is a non-selective group I/II metabotropic glutamate receptor antagonist.
Memantine hydrochloride
T1443
Memantine hydrochloride (Memantine HCl) is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparki...
HexylHIBO
T22840
HexylHIBO is a type I mGluR antagonist that inhibits mGlu1a and mGlu5a, with Kb values of 140 and 110 μM, respectively.HexylHIBO decreases sEPSC in rats.
Caroverine hydrochloride
T9133
Caroverine hydrochloride (Caroverine HCL) is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It is also an antioxidant and c...
CBiPES hydrochloride
T22638
CBiPES hydrochloride (CBiPES HCl) is a potent orthosteric modulator of the mGlu2 receptor with an EC50 value of 92.8 nM.CBiPES hydrochloride blocks the action of...
Latrepirdine dihydrochloride
T6562
Latrepirdine dihydrochloride (Dimebolin dihydrochloride) is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors,...
VU6012962
T13323
VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).
cis-PDA
T20571
cis-PDA (cis PDA) is a general ionotropic receptor antagonist. cis-PDA acts by blocking NMDA, AMPA, and kainate-mediated responses.
(-)-Camphoric acid
T20191
(-)-Camphoric acid (L-Camphoric acid) is a less active enantiomer of Camphoric acid which induces GluR expression.
VU0155094
T9011
VU0155094 (ML 397) is a positive allosteric modulator with differential activity at the various group III mGluRs.
LY377604
T15819
LY377604 is a human β3-adrenergic receptor agonist (EC50: 2.4 nM). It also a β1- and β2-adrenergic receptor antagonist.
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TargetMol