HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.

Cat. No.	Product name	CAS No.	Purity
T6007	Birinapant	1260251-31-7	99.47%
T6007	Birinapant (TL32711) is a synthetic small molecule that is both a peptidomimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IA...
TP1785L	Peptide T acetate(106362-32-7 free base)	TP1785L	99.47%
TP1785L	Peptide T acetate is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a synthetic octapeptide whose possible mechanism of action is the competitive...
TN2283	Tripterifordin	139122-81-9	99.46%
TN2283	Tripterifordin shows anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 1 microgram/ml.
T38861L	Tat-beclin 1 acetate		99.44%
T38861L	Tat-beclin 1 acetate is a potent inducer of autophagy and interacts with the negative regulator of autophagy, GAPR-1. Tat-beclin 1 acetate decreases the accumula...
T14489	Azvudine	1011529-10-4	99.42%
T14489	Azvudine (FNC) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine inhibits NRTI-resistant viral...
T0825	Ebselen	60940-34-3	99.38%
T0825	Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimet...
T4S1999	Valepotriate	18296-44-1	99.38%
T4S1999	Valepotriate (Valtrate) fraction can have sedative effects and affect behavioral parameters related to recognition memory. Valepotriates, a new class of cytotoxi...
TP2092L	Apelin-17 (human, bovine) acetate	TP2092L	99.36%
TP2092L	Apelin-17 (human, bovine) acetate is an endogenous apelin receptor agonist. Potently inhibits forskolin-stimulated cAMP accumulation (pIC50 = 9.94).
Fr16741	Oxindole	59-48-3	99.34%
Fr16741	Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxi...
TP1432	Enfuvirtide acetate	914454-00-5	99.34%
TP1432	Enfuvirtide acetate salt is a linear synthetic peptide made of 36 amino acids. It has an acetylated N-terminus and a carboxamide C-terminus.
T2988	(-)-Epigallocatechin Gallate	989-51-5	99.34%
T2988	(-)-Epigallocatechin Gallate (EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. (-)-Epigallocatechin Gallate (EGCG...
T10826	CK-666	442633-00-3	99.33%
T10826	CK-666 is a cell-permeable inhibitor of actin-related protein Arp2/3 complex. It binds to the Arp2/3 complex, stabilizes the inactive state of the complex, block...
T2789	Scutellarin	27740-01-8	99.32%
T2789	Scutellarin (Scutellarein-7-glucuronide), an active flavone isolated from Scutellaria baicalensis, can inhibit RANKL-mediated MAPK and NF-κB signaling pathway in...
T6418	BMS-378806	357263-13-9	99.31%
T6418	BMS-378806 (BMS-806) selectively inhibits the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in virus.
T28578	Ro24-7429	139339-45-0	99.29%
T28578	Ro24-7429 is an effective and orally active antagonist of HIV-1 transactivator protein Tat and an inhibitor of a runt-related transcription factor 1. Ro24-7429 h...
T12399	Peldesine	133432-71-0	99.27%
T12399	Peldesine (BCX 34) is an effective, competitive, reversible, and orally active inhibitor of purine nucleoside phosphorylase. Peldesine inhibits T-cell proliferat...
T6644	Rolipram	61413-54-5	99.26%
T6644	Rolipram (SB 95952) is a phosphodiesterase 4 inhibitor with antidepressant properties.
T1649	Tenofovir	147127-20-6	99.24%
T1649	Tenofovir (GS 1278) is an adenine analog REVERSE TRANSC-RIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIO...
T2728	Limonin	1180-71-8	99.2%
T2728	Limonin (Citrolimonin) is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.
T70692	ST7612AA1	1428535-92-5	99.19%
T70692	ST7612AA1 is a novel potent and oral HDCA inhibitor that acts as an HIV-1 latency reactivator. ST7612AA1 showed significant antitumor activity at low concentrati...