HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.

Cat. No.	Product name	CAS No.	Purity
T20062	Thiamine disulfide	67-16-3	99.18%
T20062	Thiamine disulfide (Algoneurina) , also known as thiamin or vitamin B1, is a vitamin found in food and manufactured as a dietary supplement and medication. Thiam...
T7111	Tenofovir Disoproxil	201341-05-1	99.17%
T7111	Tenofovir Disoproxil (GS 4331) is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.
T3772	Maslinic acid	4373-41-5	99.16%
T3772	Maslinic acid (Crategolic acid) is a DNA polymerase B inhibitor.
T1404	Stavudine	3056-17-5	99.15%
T1404	Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.
T12715	Reverse transcriptase-IN-1	2380001-43-2	99.14%
T12715	Reverse transcriptase-IN-1 is a diarylbenzopyrimidine (DABP) analogue and a potent inhibitor of HIV-1 nonnucleoside reverse transcriptase with an IC50of 13.7 nM...
T1623	Lopinavir	192725-17-0	99.14%
T1623	Lopinavir (ABT-378) is a peptidomimetic HIV protease inhibitor that retains activity against HIV protease with the Val 82 mutation. Lopinavir is less affected by...
T2383	Panobinostat	404950-80-7	99.14%
T2383	Panobinostat (NVP-LBH589) is a broad-spectrum HDAC inhibitor (IC50=5 nM) with oral activity and non-selectivity. Panobinostat has antitumor activity and induces ...
T1020	Doxorubicin hydrochloride	25316-40-9	99.13%
T1020	Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM). ...
T2177	Kaempferol	520-18-3	99.11%
T2177	Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ. Kaempferol has a wide range of antitumor, anti-inflammatory, antioxidant, ...
T6198	Dolutegravir	1051375-16-6	99.08%
T6198	Dolutegravir (GSK1349572) (IC50=2.7 nM), a two-metal-binding HIV integrase inhibitor, exhibits medium activity against raltegravir-resistant signature mutants Y1...
T2S0223	Isosinensetin	17290-70-9	99.05%
T2S0223	1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.
T15436	GSK2838232	1443460-91-0	99.05%
T15436	GSK2838232 inhibit HIV reverse transcriptase activity across a broad panel of HIV-1 isolates,GSK2838232 is novel human immune virus (HIV) maturation inhibitor.
T2239L	Raltegravir	518048-05-0	99.05%
T2239L	Raltegravir (MK-0518) is a pyrrolidinone derivative and HIV INTEGRASE INHIBITOR that is used in combination with other ANTI-HIV AGENTS for the treatment of HIV I...
TN1047	Ingenol mebutate	75567-37-2	99.04%
TN1047	Ingenol mebutate (Ingenol 3-Angelate) is a potent activator of PKC subtypes including PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε with Kis of 0.3, 0.105, 0.162, 0.376,...
T7208	AMD 3465 hexahydrobromide	185991-07-5	99.03%
T7208	AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity.
T7055	Bz-RS-ISer(3-Ph)-Ome	32981-85-4	99.01%
T7055	Bz-RS-ISer(3-Ph)-Ome (Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate) is a paclitaxel derivative that inhibits the HSV replication cycle at low cyt...
T3732	Decanedioic acid	111-20-6	99%
T3732	Decanedioic acid (Sebacinsaure) is a saturated, straight-chain naturally occurring dicarboxylic acid.
T2409	Tenofovir alafenamide	379270-37-8	99%
T2409	Tenofovir alafenamide (GS-7340) is a nucleotide reverse transcriptase inhibitor (NRTI) and a novel ester prodrug of the antiretroviral tenofovir.
T1602	Valproic acid sodium salt	1069-66-5	99%
T1602	Valproic acid sodium salt (Sodium Valproate) is the sodium salt form of valproic acid with anti-epileptic activity. Valproic acid sodium salt is converted into i...
TQ0297	Cenicriviroc	497223-25-3	98.98%
TQ0297	Cenicriviroc (TAK-652) is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-infl...