HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.

Cat. No.	Product name	CAS No.	Purity
T2775	Baicalin	21967-41-9	98.96%
T2775	Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIV proper...
T21474	Navuridine	84472-85-5	98.9%
T21474	Navuridine (AZdU) is an oral active inhibitor of HIV reverse transcriptase with a relatively short half-life.
T2330	Rilpivirine	500287-72-9	98.83%
T2330	Rilpivirine (R278474) is a diarylpyrimidine derivative and reverse transcriptase inhibitor with antiviral activity against HIV-1 that is used in the treatment of...
T23910	Cosalane	154212-56-3	98.82%
T23910	Cosalane (NSC 658586) is an HIV replication inhibitor, an inhibitor of chemokine receptor 7 (CCR7) signalling in humans and mice, with antiviral activity that bl...
T40293	GPS491	2655502-29-5	98.81%
T40293	GPS491 has antiviral activity and inhibits HIV-1, adenovirus, and coronavirus replication by altering RNA processing.
T67926	(S)-(+)-N-3-Benzylnirvanol	790676-40-3	98.76%
T67926	(S)-(+)-N-3-Benzylnirvanol (ZSN-76403) is a cytochrome P450 CYP2C19 inhibitor with an IC50 value of 0.179 µM that can be used to study HIV infection.
T6S2391	L-Chicoric Acid	70831-56-0	98.74%
T6S2391	L-Chicoric Acid (trans-Caffeoyltartaric acid) has been shown to inhibit hyaluronidase and HIV-1 integrase, and to possess phagoeytosis stimulatory activity in vi...
T5429	Theaflavin 3,3'-digallate	30462-35-2	98.71%
T5429	Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopre...
TL0006	Cichoric Acid	6537-80-0	98.57%
TL0006	Cichoric Acid (Dicaffeoyltartaric acid) is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a ...
T1125	Shikonin	517-89-5	98.54%
T1125	Shikonin (Anchusa acid) is a natural product, a TMEM16A chloride channel inhibitor (IC50=6.5 μM) and selective PKM2 inhibitor. Shikonin exhibits antitumor, anti-...
T6029	ONX-0914	960374-59-8	98.47%
T6029	ONX-0914 (PR-957) is an effective and specific immunoproteasome inhibitor, which has minimal cross-reactivity for the constitutive proteasome.
TN1622	Ermanin	20869-95-8	98.46%
TN1622	Ermanin is a flavonoid isolated from Tanacetum microphyllum.Ermanin inhibits platelet aggregation and has anti-tuberculosis and anti-viral/bacterial properties.E...
T27625	IQP-0528	301297-45-0	98.45%
T27625	IQP-0528 is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI) that has potential for the treatment of HIV infection by blocking viral entry and sho...
T20489	Benzalphthalide	575-61-1	98.41%
T20489	Benzalphthalide (NSC-2824) is a chemical compound with anti-HIV activity.
T2865	Oleanolic Acid	508-02-1	98.4%
T2865	Oleanolic Acid (Caryophyllin) is a natural compound with anti-tumor activities, which are widely distributed in plants.
T63143	DENV-IN-5	2375781-06-7	98.39%
T63143	Denv-in-5 is an effective and selective dengue virus (DENV) inhibitor with EC50 values of 1.47, 9.23, 7.08, 8.91 μM for denV-I-IV and 0.1512 μM for HIV-1IIIB.
T0200	α-Lipoic Acid	1077-28-7	98.39%
T0200	α-Lipoic Acid (DL-α-Lipoic acid) an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is bio...
T7282	Tenofovir alafenamide hemifumarate	1392275-56-7	98.37%
T7282	Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TF...
T0836	Sulfadoxine	2447-57-6	98.36%
T0836	Sulfadoxine (Sulphadoxine) is a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial propert...
T11538	Hck-IN-1	1473404-51-1	98.29%
T11538	Hck-IN-1 is a selective Nef-dependent Hck inhibitor (IC50s: 2.8 μM and >20 μM for Nef:Hck complex and Hck) with antiretroviral activity. Hck-IN-1 is a direct and...