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HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T6653 Salmeterol Xinafoate 94749-08-3 98.24%
Salmeterol Xinafoate
Salmeterol Xinafoate (GR 33343X xinafoate) is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma sympto...
T3523 Fostemsavir 864953-29-7 98.22%
Fostemsavir
Fostemsavir (BMS-663068) is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection.
T4697 ABBV-744 2138861-99-9 98.2%
ABBV-744
ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.
T35340 Bictegravir Sodium 1807988-02-8 98.19%
Bictegravir Sodium
Bictegravir Sodium (GS-9883 Sodium) is a potent inhibitor of HIV-1 integrase, with an IC50 of 7.5 nM. Bictegravir Sodium exhibits potent and selective anti-HIV a...
T4S1387 Isoescin IA 219944-39-5 98.18%
Isoescin IA
Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. It has anti-HIV-1 protease activity.
T3465 Vesnarinone 81840-15-5 98.13%
Vesnarinone
Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but min...
T38514 PMEDAP 113852-41-8 98.12%
PMEDAP
PMEDAP is a potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality and an inhibitor of human immunodeficiency vi...
T4S1521 1,4-Dicaffeoylquinic acid 1182-34-9 98.09%
1,4-Dicaffeoylquinic acid
1,4-Dicaffeoylquinic acid has antioxidant activity.1,4-Dicaffeoylquinic acid is a potent and highly selective class of HIV-1 integrase inhibitors, inhibitsHIV-1 ...
T2480 Apabetalone 1044870-39-4 98.08%
Apabetalone
Apabetalone (RVX000222) , an effective BET bromodomain inhibitor, has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disea...
T32804 LJ-001 851305-26-5 98.02%
LJ-001
LJ-001 shows broad-spectrum activity against virtually all enveloped RNA and DNA viruses. LJ001 inhibits the infection of transmissible gastroenteritis virus (TG...
T60742 HIV-1 integrase inhibitor 8 1568-80-5 98.01%
HIV-1 integrase inhibitor 8
HIV-1 integrase inhibitor 8 is an inhibitor of HIV-1 integrase. Integration is a required step in HIV replication [1].
T1883 Des(benzylpyridyl) Atazanavi 1192224-24-0 98%
Des(benzylpyridyl) Atazanavi
The N-dealkylated metabolite (M1) of Atazanavir, a HIV protease inhibitor.
T8116 Azulene 275-51-4 98%
Azulene
Azulene (Bicyclo[5.3.0]Decapentaene) is a natural product.
T6001 Nelfinavir Mesylate 159989-65-8 98%
Nelfinavir Mesylate
Nelfinavir Mesylate (Viracept) is an effective HIV protease inhibitor (Ki: 2 nM).
T7455 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride 173676-59-0 98%
4-Chloro-2-(trifluoroacetyl)aniline hydrochloride
4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is an inhibitor of HIV-1 RT (HIV reverse transcriptase) .
T7382 NBD-557 333352-59-3 98%
NBD-557
NBD-557 is a potentially HIV-1 inhibitor.
T5965 Ditiocarb sodium 148-18-5 98%
Ditiocarb sodium
Ditiocarb sodium (Sodium diethyldithiocarbamate) (sodium diethiocarbamate) is a copper reagent, which reacts with Cu2 + solution to form a complex and improves t...
T0474 Erythromycin ethylsuccinate 1264-62-6 98%
Erythromycin ethylsuccinate
Erythromycin ethylsuccinate (EES) is a macrolide antibiotic, produced by Streptomyces erythreus.
T67737 Gp120-α4β7 binding inhibitor 11 869474-87-3 97.61%
gp120-α4β7 binding inhibitor 11
gp120-α4β7 binding inhibitor 11 is an anti-HIV agent. gp120-α4β7 binding inhibitor 11 interferes the binding of HIV associated glycoprotein gp12G with the integr...
T67833 HIV-1 inhibitor-54 2771211-71-1 97.61%
HIV-1 inhibitor-54
HIV-1 inhibitor-54 is a potent HIV-1 inhibitor showing anti-HIV activity (EC50 : 32 nM) against WT HIV-1 (strain IIIB) x in MT-4 cells.HIV-1 inhibitor-54 can be ...
Salmeterol Xinafoate
T6653
Salmeterol Xinafoate (GR 33343X xinafoate) is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma sympto...
Fostemsavir
T3523
Fostemsavir (BMS-663068) is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection.
ABBV-744
T4697
ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.
Bictegravir Sodium
T35340
Bictegravir Sodium (GS-9883 Sodium) is a potent inhibitor of HIV-1 integrase, with an IC50 of 7.5 nM. Bictegravir Sodium exhibits potent and selective anti-HIV a...
Isoescin IA
T4S1387
Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. It has anti-HIV-1 protease activity.
Vesnarinone
T3465
Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but min...
PMEDAP
T38514
PMEDAP is a potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality and an inhibitor of human immunodeficiency vi...
1,4-Dicaffeoylquinic acid
T4S1521
1,4-Dicaffeoylquinic acid has antioxidant activity.1,4-Dicaffeoylquinic acid is a potent and highly selective class of HIV-1 integrase inhibitors, inhibitsHIV-1 ...
Apabetalone
T2480
Apabetalone (RVX000222) , an effective BET bromodomain inhibitor, has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disea...
LJ-001
T32804
LJ-001 shows broad-spectrum activity against virtually all enveloped RNA and DNA viruses. LJ001 inhibits the infection of transmissible gastroenteritis virus (TG...
HIV-1 integrase inhibitor 8
T60742
HIV-1 integrase inhibitor 8 is an inhibitor of HIV-1 integrase. Integration is a required step in HIV replication [1].
Des(benzylpyridyl) Atazanavi
T1883
The N-dealkylated metabolite (M1) of Atazanavir, a HIV protease inhibitor.
Azulene
T8116
Azulene (Bicyclo[5.3.0]Decapentaene) is a natural product.
Nelfinavir Mesylate
T6001
Nelfinavir Mesylate (Viracept) is an effective HIV protease inhibitor (Ki: 2 nM).
4-Chloro-2-(trifluoroacetyl)aniline hydrochloride
T7455
4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is an inhibitor of HIV-1 RT (HIV reverse transcriptase) .
NBD-557
T7382
NBD-557 is a potentially HIV-1 inhibitor.
Ditiocarb sodium
T5965
Ditiocarb sodium (Sodium diethyldithiocarbamate) (sodium diethiocarbamate) is a copper reagent, which reacts with Cu2 + solution to form a complex and improves t...
Erythromycin ethylsuccinate
T0474
Erythromycin ethylsuccinate (EES) is a macrolide antibiotic, produced by Streptomyces erythreus.
gp120-α4β7 binding inhibitor 11
T67737
gp120-α4β7 binding inhibitor 11 is an anti-HIV agent. gp120-α4β7 binding inhibitor 11 interferes the binding of HIV associated glycoprotein gp12G with the integr...
HIV-1 inhibitor-54
T67833
HIV-1 inhibitor-54 is a potent HIV-1 inhibitor showing anti-HIV activity (EC50 : 32 nM) against WT HIV-1 (strain IIIB) x in MT-4 cells.HIV-1 inhibitor-54 can be ...
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TargetMol