HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.

Cat. No.	Product name	CAS No.	Purity
T0676	Hydroxyurea	127-07-1	99.92%
T0676	Hydroxyurea (Hydroxycarbamide), an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
T16500	PF-3450074	1352879-65-2	99.92%
T16500	PF-3450074 (PF-74) acts at an early stage of HIV-1 infection inhibits viral replication by directly competing with the binding of CPSF6 (nuclear host factors cle...
T11451	GPI-1046	186452-09-5	99.91%
T11451	GPI-1046 is an immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in ...
T1416	Zidovudine	30516-87-1	99.91%
T1416	Zidovudine (ZDV) is a synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in...
TP1149	HIV-1 Rev (34-50)	141237-50-5	99.91%
TP1149	HIV-1 Rev (34-50) (HIV-1 rev Protein (34-50)) is a 17 amino acid peptide with anti-HIV-1 activity. HIV-1 Rev (34-50) is derived from the Rev-responsive element-b...
T9063	Clathrin-IN-1	1332879-52-3	99.91%
T9063	Clathrin-IN-1 is a inhibitor of clathrin, and inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. It has the potent...
T31860L	(Iso)-Fosdevirine	2869918-45-4	99.90%
T31860L	(Iso)-Fosdevirine ( (Iso)-GSK2248761) is a selective and potent non-nucleoside reverse transcriptase (NNRTI) inhibitor with anti-HIV activity for the study of ne...
T67798	(2RS)-FPMPA	135295-27-1	99.90%
T67798	(2RS)-FPMPA（FPMPA） has antiviral activity with an IC50 value of 1.85 μM measured in human MT12 cells infected with SHIV (DH4R).
T1743	Aprepitant	170729-80-3	99.9%
T1743	Aprepitant (Aprepitant`) is a Substance P/Neurokinin-1 Receptor Antagonist. The mechanism of action of aprepitant is as a Neurokinin 1 Antagonist, and Cytochrome...
T15210	Elsulfavirine	868046-19-9	99.89%
T15210	Elsulfavirine (VM-1500) is an HIV-1 infection reverse transcriptase inhibitor. It is a new anti-HIV drug.
T16154	MS417	916489-36-6	99.88%
T16154	MS417 (GTPL7512) is an inhibitor of BET-specific BRD4(BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively), with weak selectivit...
T2615	Flavopiridol hydrochloride	131740-09-5	99.88%
T2615	Flavopiridol hydrochloride (MDL 107826A) is a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib ...
T6377	Aloperine	56293-29-9	99.88%
T6377	Aloperine exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.
T13974	ZL0580	2377151-10-3	99.87%
T13974	ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV pr...
T2409L	Tenofovir Disoproxil Fumarate	202138-50-9	99.86%
T2409L	Tenofovir Disoproxil Fumarate (GS-1278 Disoproxil Fumarate) is a pro-drug, fumaric acid salt form of tenofovir, a nucleoside reverse transcriptase inhibitor anal...
T10133	3'-Azido-3'-deoxy-5-methylcytidine	1282040-14-5	99.86%
T10133	3'-Azido-3'-deoxy-5-methylcytidine inhibits HIV-1 reverse transcriptase(EC50 = 0.06 μM) and is an effective inhibitor of xenotropic murine leukemia-related retro...
T39755	Pirmitegravir	2245231-10-9	99.86%
T39755	Pirmitegravir (STP0404) is a potent and selective inhibitor of allosteric integrase (ALLINI) targeting the LEDGF/p75 binding site. Pirmitegravir inhibits PBMC. P...
T3614	Inosine pranobex	36703-88-5	99.85%
T3614	Inosine pranobex (Delimmun) has a number of immunomodulatory effects, including inducing T-lymphocyte differentiation, augmenting macrophage and NK cell function...
T6367	Abacavir sulfate	188062-50-2	99.85%
T6367	Abacavir sulfate (Ziagen) , a nucleoside analogue, effectively utilize its antiviral activity
T6837	Flavopiridol	146426-40-6	99.85%
T6837	Flavopiridol (Alvocidib) (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective fo...