HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.

Cat. No.	Product name	CAS No.	Purity
T27260	Emivirine	149950-60-7	99.68%
T27260	Emivirine (MKC-442) is a potent and selective nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1.
T0753	Salicylanilide	87-17-2	99.68%
T0753	Salicylanilide (2-Hydroxybenzanilide)s are a group of compounds with antiviral potency, antibacterial and antifungal activities.
TP1348	FC131 TFA (606968-52-9 free base)	842166-42-1	99.67%
TP1348	FC131 TFA (606968-52-9 free base) (FC131 TFA) is an antagonist of CXCR4 that inhibits the binding of [125I] -sdf-1 to CXCR4(IC50 : 4.5 nM ), and has anti-hiv act...
T0100	Atazanavir sulfate	229975-97-7	99.67%
T0100	Atazanavir sulfate (BMS-232632 sulfate) is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with ...
T11074	Dolutegravir intermediate-1	1335210-23-5	99.67%
T11074	Dolutegravir intermediate-1 (1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid) is a new synthetic Dolutegravir in...
T4578	Tipranavir	174484-41-4	99.66%
T4578	Tipranavir is a protease inhibitor that inhibits HIV-1 resistant to more than 1 protease inhibitor .Tipranavir effectively inhibits HIV-1 protease enzyme activit...
TN4673	(+)-Nortrachelogenin	61521-74-2	99.64%
TN4673	(+)-Nortrachelogenin is a lignan isolated from Wikstroemia indica C.A. Meyer (Thymelaeaceae). (+)-Nortrachelogenin possesses antileukemic activity.
T0194	Chloroquine phosphate	50-63-5	99.64%
T0194	Chloroquine phosphate (Aralen phosphate) is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of...
T4557	Amylmetacresol	1300-94-3	99.64%
T4557	Amylmetacresol (5-Methyl-2-Pentylphenol) is used in the treatment of sore throat or 'acute sore throat', pharyngitis, tonsillitis and laryngitis. As well as in t...
T6246	Cobicistat	1004316-88-4	99.62%
T6246	Cobicistat (GS-9350) is a carbamate and thiazole derivative that functions as a CYTOCHROME P450 CYP3A INHIBITOR to enhance the concentration of ANTI-HIV AGENTS, ...
T9039	HIV-1 Nef-IN-1	13728-56-8	99.62%
T9039	HIV-1 Nef-IN-1 is an inhibitor of HIV-1 Nef protein. It efficiently competes for Nef-SH3Hck interactions(Kd : 6.7 μM).
TN2158	Robinetin	490-31-3	99.61%
TN2158	Robinetin (3,3',4',5',7-Pentahydroxyflavone) has antioxidant and antiradical activities, inhibits EYPC membrane lipid peroxidation and HbA glycosylation with hig...
T1595	Nevirapine	129618-40-2	99.6%
T1595	Nevirapine (NVP) is a benzodiazepine non-nucleoside reverse transcriptase inhibitor. In combination with other antiretroviral drugs, nevirapine reduces HIV viral...
T8238	Fosamprenavir Calcium Salt	226700-81-8	99.59%
T8238	Fosamprenavir Calcium Salt (GW433908G) (GW433908G) is a phosphate ester prodrug of the antiretroviral protease inhibitor Amprenavir, with improved solubility. Fo...
T5782	Bevirimat	174022-42-5	99.58%
T5782	Bevirimat (PA-457) is a first-in-class inhibitor of HIV-1 maturation, blocking the cleavage of the Gag capsid (CA) precursor, CA-SPI, to mature CA protein during...
T7499	TAK-779	229005-80-5	99.58%
T7499	TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
T2551	Etravirine	269055-15-4	99.56%
T2551	Etravirine (R165335) is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor. Etravirine is designed to be active against HIV isolates with mutation...
T0984	5-Fluorouracil	51-21-8	99.56%
T0984	5-Fluorouracil (5-FU) is a uracil analog, an inhibitor of DNA synthesis. 5-Fluorouracil has antitumor activity and affects pyrimidine synthesis through inhibitio...
T0153	Oltipraz	64224-21-1	99.56%
T0153	Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes...
T10603	BRD-6929	849234-64-6	99.54%
T10603	BRD-6929 is a selective, brain-penetrant HDAC1 and HDAC2 inhibitor (IC50: 1 and 8 nM). BRD-6929 (Cpd-60) shows high-affinity to HDAC1 and HDAC2 (Kis: 0.2 and 1....