HSP

Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock, but are now known to also be expressed during other stresses including exposure to cold, UV light and during wound healing or tissue remodeling. Many members of this group perform chaperone functions by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress.

Cat. No.	Product name	CAS No.	Purity
TN4160	Goniothalamin	17303-67-2	98%
TN4160	Goniothalamin induces apoptosis in various cancer cell lines and has gastroprotective activity.
TN4604	Myricanone	32492-74-3	98%
TN4604	Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
T6804	Chetomin	1403-36-7	98%
T6804	Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrati...
T11355	Gamitrinib TPP	1131626-46-4	98%
T11355	Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor exhibiting potent anti-cancer activity. Additionally, Gamitrinib TPP functions as a mitochondrial matr...
T6442	CH5138303	959763-06-5	98%
T6442	CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.
TN3070	4beta-Hydroxywithanolide E	54334-04-2	98%
TN3070	4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progr...
T11356	Gamitrinib TPP hexafluorophosphate	1131626-47-5	98%
T11356	Gamitrinib TPP hexafluorophosphate is a potent HSP90 inhibitor that specifically targets the mitochondria, demonstrating notable anti-cancer activity. It functio...
T15671	KU-32	956498-70-7	98%
T15671	KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.
T16719	Radicicol	12772-57-5	98%
T16719	Radicicol is an antifungal antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB. Radicicol is an inhibitor of Hsp90 (IC50: ...
T5008	Teprenone	6809-52-5	99.96%
T5008	Teprenone (Geranylgeranylacetone) is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).
T6305	SNX2112	908112-43-6	99.95%
T6305	SNX2112 (PF 04928473) is an orally active Hsp90 inhibitor, with a Kd of 16 nM.
T2309	Ganetespib	888216-25-9	99.95%
T2309	Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.
T6297	Alvespimycin hydrochloride	467214-21-7	99.94%
T6297	Alvespimycin hydrochloride (BMS 826476) is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.
T3454	VER-49009	558640-51-0	99.93%
T3454	VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).
T13554	Arimoclomol maleate	289893-26-1	99.9%
T13554	Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.
T39321	CC-99677	1887069-10-4	99.87%
T39321	CC-99677 (Gamcemetinib) is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular pot...
T2908	Palmitic acid	57-10-3	99.87%
T2908	Palmitic acid (Cetylic acid) is a natural product, a common saturated fatty acid found in animals, plants and microorganisms. Palmitic acid has antitumor activit...
T28824	SNX0723	1073969-18-2	99.86%
T28824	SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity. SNX0723 shows high binding affinity for HsHsp90 and PfHsp90 with Kis of 4.4 and 47 nM, respect...
T2258	VER-50589	747413-08-7	99.85%
T2258	VER-50589 is a potent HSP90 inhibitor.
T6284	Onalespib	912999-49-6	99.82%
T6284	Onalespib (AT13387) is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Onales...