HSP

Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock, but are now known to also be expressed during other stresses including exposure to cold, UV light and during wound healing or tissue remodeling. Many members of this group perform chaperone functions by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress.

Cat. No.	Product name	CAS No.	Purity
T6609	NMS-E973	1253584-84-7	99.82%
T6609	NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.
T13553	Arimoclomol	289893-25-0	99.81%
T13553	Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (ALS...
T9202	DDO-5936	2355377-13-6	99.69%
T9202	DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.
T8858	DTHIB	897326-30-6	99.69%
T8858	DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.
T8829	2',4'-DIHYDROXYCHALCONE	1776-30-3	99.59%
T8829	2',4'-DIHYDROXYCHALCONE (2',4'-DHC) as a compound with Hsp90 inhibitory and antifungal effects
T67836	AT-533	908112-37-8	99.54%
T67836	AT-533 is a potent inhibitor of Hsp90 and HSV. AT-533 blocks the HIF-1α/VEGF/VEGFR-2 signaling pathway, leading to suppress tumor growth and angiogenesis. AT-533...
T16994	Pimitespib	1260533-36-5	99.49%
T16994	Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively).
T5350	JG-98	1456551-16-8	99.35%
T5350	JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7 μM).
T6290	Tanespimycin	75747-14-7	99.34%
T6290	Tanespimycin (KOS 953) (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM).
T6210	Pifithrin-μ	64984-31-2	99.33%
T6210	Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.
T6170	Elesclomol	488832-69-5	99.33%
T6170	Elesclomol (STA-4783) is an oxidative stress inducer and a highly lipophilic copper ion carrier. Elesclomol induces apoptosis in tumor cells and is used in coppe...
T1501	Rifabutin	72559-06-9	99.27%
T1501	Rifabutin (LM-427) inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesi...
T9804	NPX800	1693734-80-3	99.26%
T9804	NPX800 is an inhibitor of heat shock factor 1 (HSF1) and can be used in studies about the treatment of cancer.
T1989	Luminespib	747412-49-3	99.25%
T1989	Luminespib (VER-52296) is a new-type inhibitor of HSP90 (IC50s: 7.8/21 nM for HSP90α/β in cell free assay).
T3594	ML346	100872-83-1	99.25%
T3594	ML346 is a novel activator of Hsp70.
T70353	JG-231	1627126-59-3	99.21%
T70353	JG-231 is a JG-98 analog with anticancer activity.JG-231 inhibits the MDA-MB-231 xenograft tumor model of triple-negative breast cancer (TNBC).JG-231 inhibits th...
T2268	VER49009	940289-57-6	99.17%
T2268	VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM).
T2114	VER-82576	847559-80-2	99.16%
T2114	VER-82576 (NVP-BEP800), a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.
T67897	GRP78-IN-3	2707510-30-1	99.11%
T67897	GRP78-IN-3, a potent small-molecule-competitive inhibitor of Hsp70 substrate binding and is a selective Grp78 (HSPA5) inhibitor with an IC50 of 0.59 μM. GRP78-IN...
T6341	PF04929113	908115-27-5	99.06%
T6341	PF04929113 (SNX-5422) is a synthetic, novel, small molecule Hsp90 Inhibitor. As an oral formulation that demonstrates strong efficacy and tolerability, PF0492911...