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HSP

Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock, but are now known to also be expressed during other stresses including exposure to cold, UV light and during wound healing or tissue remodeling. Many members of this group perform chaperone functions by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress.
Cat. No. Product name CAS No. Purity Chemical Structure
T7010 VER-155008 1134156-31-2 98%
VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold se...
T8829 2',4'-DIHYDROXYCHALCONE 1776-30-3 98%
2',4'-Dihydroxychalcone as a compound with Hsp90 inhibitory and antifungal effects
T9996 NCT-58 2411429-33-7 98%
NCT-58 is a potent C-terminal HSP90 inhibitor. NCT-58 does not induce the heat shock response (HSR). NCT-58 elicits anti-tumor activity via the simultaneous dow...
T21883 Gedunin 2753-30-2 98%
Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer c...
T8858 DTHIB 897326-30-6 98%
DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.
T9202 DDO-5936 2355377-13-6 98%
DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.
T1501 Rifabutin 72559-06-9 98%
Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and tra...
T13553 Arimoclomol 289893-25-0 98%
Arimoclomol is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (ALS).
T2286 BIIB021 848695-25-0 98%
BIIB021 is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).
T6609 NMS-E973 1253584-84-7 98%
NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.
T6284 Onalespib 912999-49-6 98%
Onalespib is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Onalespib select...
T2179 Triptolide 38748-32-2 98%
Triptolide is a diterpenes trioxide, immunosuppressive agent extracted from the Chinese herb Tripterygium wilfordii.
T6290 Tanespimycin 75747-14-7 98%
Tanespimycin (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM).
T28824 SNX0723 1073969-18-2 98%
SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity. SNX0723 shows high binding affinity for HsHsp90 and PfHsp90 with Kis of 4.4 and 47 nM, respect...
T6855 HA15 1609402-14-3 98%
HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells t...
T2908 Palmitic acid 57-10-3 98%
Palmitic acid is the most common saturated fatty acid found in animals, plants and microorganisms with anti-tumor activity.
T3652 KRIBB11 342639-96-7 98%
KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.
T3454 VER-49009 558640-51-0 98%
VER-49009 is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).
T6297 Alvespimycin hydrochloride 467214-21-7 98%
17-DMAG is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.
T2258 VER-50589 747413-08-7 98%
VER-50589 is a potent HSP90 inhibitor.
VER-155008
T7010
VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold se...
2',4'-DIHYDROXYCHALCONE
T8829
2',4'-Dihydroxychalcone as a compound with Hsp90 inhibitory and antifungal effects
NCT-58
T9996
NCT-58 is a potent C-terminal HSP90 inhibitor. NCT-58 does not induce the heat shock response (HSR). NCT-58 elicits anti-tumor activity via the simultaneous dow...
Gedunin
T21883
Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer c...
DTHIB
T8858
DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.
DDO-5936
T9202
DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.
Rifabutin
T1501
Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and tra...
Arimoclomol
T13553
Arimoclomol is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (ALS).
BIIB021
T2286
BIIB021 is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).
NMS-E973
T6609
NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.
Onalespib
T6284
Onalespib is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Onalespib select...
Triptolide
T2179
Triptolide is a diterpenes trioxide, immunosuppressive agent extracted from the Chinese herb Tripterygium wilfordii.
Tanespimycin
T6290
Tanespimycin (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM).
SNX0723
T28824
SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity. SNX0723 shows high binding affinity for HsHsp90 and PfHsp90 with Kis of 4.4 and 47 nM, respect...
HA15
T6855
HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells t...
Palmitic acid
T2908
Palmitic acid is the most common saturated fatty acid found in animals, plants and microorganisms with anti-tumor activity.
KRIBB11
T3652
KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.
VER-49009
T3454
VER-49009 is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).
Alvespimycin hydrochloride
T6297
17-DMAG is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.
VER-50589
T2258
VER-50589 is a potent HSP90 inhibitor.
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