T11436 |
GNA002
|
1385035-79-9
|
98%
|
|
GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).
|
TN5097 |
Tanshindiol C
|
97465-71-9
|
98%
|
|
Tanshindiol C protects macrophages from oxLDL induced foam cell formation via activation of Prdx1/ABCA1 signaling and that Prdx1 may be a novel target for therap...
|
T22342 |
GSK3368715 3HCl
|
2227587-26-8
|
98%
|
|
GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 ...
|
T16577 |
PRMT5-IN-2
|
1989620-04-3
|
98%
|
|
PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5.
|
T6292 |
3-Deazaneplanocin A
|
102052-95-9
|
98%
|
|
3-Deazaneplanocin A (DZNep) is an attractive epigenetic anticancer agent through the inhibition of the cellular enhancer of zeste homolog 2 (EZH2) protein.
|
TN5096 |
Tanshindiol B
|
97465-70-8
|
98%
|
|
Tanshindiol B possesses a unique anti-cancer activity whose mechanism involves the inhibition of EZH2 activity and would provide chemically valuable information ...
|
T10427 |
AZ505 ditrifluoroacetate
|
1035227-44-1
|
98%
|
|
AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).
|
T12940 |
SMYD3-IN-1
|
2095160-79-3
|
98%
|
|
SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).
|
TQ0069 |
MI-503
|
1857417-13-0
|
99.99%
|
|
MI-503 is a highly effective and orally bioavailable inhibitor of the menin-mLL interaction.
|
T6790 |
BMS-911543
|
1271022-90-2
|
99.98%
|
|
BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.
|
T6484 |
EI1
|
1418308-27-6
|
99.98%
|
|
EI1 (Ezh2 inhibitor) is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively.
|
T2167 |
Lutidinic acid
|
499-80-9
|
99.96%
|
|
lutidinic acid (2,4-Dicarboxypyridine) is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases.
|
T3201 |
WDR5-0103
|
890190-22-4
|
99.96%
|
|
WDR5-0103 (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd: 450 nM).
|
T11486 |
GSK2807 Trifluoroacetate
|
2245255-66-5
|
99.95%
|
|
GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).
|
T16435 |
PBIT
|
2514-30-9
|
99.95%
|
|
PBIT inhibits JARID1B histone demethylase (IC50 of about 3 μM). PBIT also inhibits JARID1A and JARID1C (IC50s of 6 μM and 4.9 μM, respectively). PBIT is a specif...
|
T15080 |
DC-05
|
890643-16-0
|
99.94%
|
|
DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).
|
T6879 |
LLY-507
|
1793053-37-8
|
99.93%
|
|
LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.
|
T4343 |
A-196
|
1982372-88-2
|
99.93%
|
|
A-196 is a potent and selective inhibitor of SUV420 h1 and SUV420 h2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective over othe...
|
T15201 |
MAK683
|
1951408-58-4
|
99.92%
|
|
MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay).
|
T3278 |
Piribedil
|
3605-01-4
|
99.91%
|
|
Piribedil (Trivastan) is a dopamine D2 agonist, used in the treatment of Parkinson's disease.
|