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Histone Methyltransferase

Histone methyltransferases (HMT) are histone-modifying enzymes , that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues of histone proteins. The attachment of methyl groups occurs predominantly at specific lysine or arginine residues on histones H3 and H4.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T11436 GNA002 1385035-79-9 98%
GNA002
GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).
TN5097 Tanshindiol C 97465-71-9 98%
Tanshindiol C
Tanshindiol C protects macrophages from oxLDL induced foam cell formation via activation of Prdx1/ABCA1 signaling and that Prdx1 may be a novel target for therap...
T22342 GSK3368715 3HCl 2227587-26-8 98%
GSK3368715 3HCl
GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 ...
T16577 PRMT5-IN-2 1989620-04-3 98%
PRMT5-IN-2
PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5.
T6292 3-Deazaneplanocin A 102052-95-9 98%
3-Deazaneplanocin A
3-Deazaneplanocin A (DZNep) is an attractive epigenetic anticancer agent through the inhibition of the cellular enhancer of zeste homolog 2 (EZH2) protein.
TN5096 Tanshindiol B 97465-70-8 98%
Tanshindiol B
Tanshindiol B possesses a unique anti-cancer activity whose mechanism involves the inhibition of EZH2 activity and would provide chemically valuable information ...
T10427 AZ505 ditrifluoroacetate 1035227-44-1 98%
AZ505 ditrifluoroacetate
AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).
T12940 SMYD3-IN-1 2095160-79-3 98%
SMYD3-IN-1
SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).
TQ0069 MI-503 1857417-13-0 99.99%
MI-503
MI-503 is a highly effective and orally bioavailable inhibitor of the menin-mLL interaction.
T6790 BMS-911543 1271022-90-2 99.98%
BMS-911543
BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.
T6484 EI1 1418308-27-6 99.98%
EI1
EI1 (Ezh2 inhibitor) is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively.
T2167 Lutidinic acid 499-80-9 99.96%
lutidinic acid
lutidinic acid (2,4-Dicarboxypyridine) is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases.
T3201 WDR5-0103 890190-22-4 99.96%
WDR5-0103
WDR5-0103 (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd: 450 nM).
T11486 GSK2807 Trifluoroacetate 2245255-66-5 99.95%
GSK2807 Trifluoroacetate
GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).
T16435 PBIT 2514-30-9 99.95%
PBIT
PBIT inhibits JARID1B histone demethylase (IC50 of about 3 μM). PBIT also inhibits JARID1A and JARID1C (IC50s of 6 μM and 4.9 μM, respectively). PBIT is a specif...
T15080 DC-05 890643-16-0 99.94%
DC-05
DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).
T6879 LLY-507 1793053-37-8 99.93%
LLY-507
LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.
T4343 A-196 1982372-88-2 99.93%
A-196
A-196 is a potent and selective inhibitor of SUV420 h1 and SUV420 h2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective over othe...
T15201 MAK683 1951408-58-4 99.92%
MAK683
MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay).
T3278 Piribedil 3605-01-4 99.91%
Piribedil
Piribedil (Trivastan) is a dopamine D2 agonist, used in the treatment of Parkinson's disease.
GNA002
T11436
GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).
Tanshindiol C
TN5097
Tanshindiol C protects macrophages from oxLDL induced foam cell formation via activation of Prdx1/ABCA1 signaling and that Prdx1 may be a novel target for therap...
GSK3368715 3HCl
T22342
GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 ...
PRMT5-IN-2
T16577
PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5.
3-Deazaneplanocin A
T6292
3-Deazaneplanocin A (DZNep) is an attractive epigenetic anticancer agent through the inhibition of the cellular enhancer of zeste homolog 2 (EZH2) protein.
Tanshindiol B
TN5096
Tanshindiol B possesses a unique anti-cancer activity whose mechanism involves the inhibition of EZH2 activity and would provide chemically valuable information ...
AZ505 ditrifluoroacetate
T10427
AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).
SMYD3-IN-1
T12940
SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).
MI-503
TQ0069
MI-503 is a highly effective and orally bioavailable inhibitor of the menin-mLL interaction.
BMS-911543
T6790
BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.
EI1
T6484
EI1 (Ezh2 inhibitor) is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively.
lutidinic acid
T2167
lutidinic acid (2,4-Dicarboxypyridine) is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases.
WDR5-0103
T3201
WDR5-0103 (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd: 450 nM).
GSK2807 Trifluoroacetate
T11486
GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).
PBIT
T16435
PBIT inhibits JARID1B histone demethylase (IC50 of about 3 μM). PBIT also inhibits JARID1A and JARID1C (IC50s of 6 μM and 4.9 μM, respectively). PBIT is a specif...
DC-05
T15080
DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).
LLY-507
T6879
LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.
A-196
T4343
A-196 is a potent and selective inhibitor of SUV420 h1 and SUV420 h2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective over othe...
MAK683
T15201
MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay).
Piribedil
T3278
Piribedil (Trivastan) is a dopamine D2 agonist, used in the treatment of Parkinson's disease.
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