Histone Methyltransferase

Histone methyltransferases (HMT) are histone-modifying enzymes , that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues of histone proteins. The attachment of methyl groups occurs predominantly at specific lysine or arginine residues on histones H3 and H4.

Cat. No.	Product name	CAS No.	Purity
T3257	UNC0638	1255580-76-7	99.53%
T3257	UNC0638 is an inhibitor of β-protein lysine methyltransferases G9a(IC50<15 nM) and GLP(IC50=19 nM) with excellent potency and selectivity over a wide range of ep...
T6810	CPI-360	1802175-06-9	99.52%
T6810	CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 μM, EC50: 0.080 μM) that shows antitumor activity in an EZH200-dependent tumor xenograft model.
T3057	UNC1999	1431612-23-5	99.49%
T3057	UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45).
T9329	BRD0639	2760881-74-9	99.46%
T9329	BRD0639 is a pioneering inhibitor targeting the interaction between PRMT5 and its substrate adaptor. As a competitive inhibitor of the PRMT5 binding motif (PBM),...
T2079	GSK126	1346574-57-9	99.43%
T2079	GSK126 (GSK2816126A) is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM).
T21767	MS37452	423748-02-1	99.39%
T21767	MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).
T36631	BAY-6035	2247890-13-5	99.39%
T36631	BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3). BAY-6035 has more than 100-fold selectivity over other histone methyltransferases.
T60002	DC-S239	303141-21-1	99.36%
T60002	DC-S239 (DC-S239) is a selective inhibitor of histone methyltransferase SETD7 (IC50 = 4.59 μM) with anticancer activity.
T6853	GSK591	1616391-87-7	99.35%
T6853	GSK591 (GSK3203591), Alternative Names are EPZ015866, GSK3203591, is a potent selective inhibitor of the arginine methyltransferase PRMT5 (IC50=11 nM).
T4583	PFI-2 hydrochloride	1627607-87-7	99.31%
T4583	PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM), 5...
T8768	MM-102 TFA	1883545-52-5	99.3%
T8768	MM-102 TFA (HMTase Inhibitor IX TFA) is a potent WDR5/MLL interaction inhibitor, achieves IC50 = 2.4 nM. MM-102 compound prevents the interaction between mixed l...
T6076	EPZ015666	1616391-65-1	99.29%
T6076	EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 enzymatic activity.
TQ0058	MI-463	1628317-18-9	99.28%
TQ0058	MI-463 is a potent and orally bioavailable inhibitor of the menin-mLL interaction (IC50: 15.3 nM).
T17204	UNC0321	1238673-32-9	99.25%
T17204	UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays. UNC0321 inhibits GLP ...
T3099	Pinometostat	1380288-87-8	99.19%
T3099	Pinometostat (EPZ-5676) has been used in trials studying the treatment of Leukemia, Acute Leukemias, Acute Myeloid Leukemia, Myelodysplastic Syndrome, and Acute ...
T7403	BAY-598	1906919-67-2	99.18%
T7403	BAY-598 is a selective inhibitor of SMYD2 with IC50 values of 27 nM.
T6809	CPI-169 racemate	1450655-76-1	99.14%
T6809	CPI-169 racemate (CPI 169) is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.
T11131	DW14800	2243709-60-4	99.12%
T11131	DW14800 is an inhibitor of PRMT5 (IC50 = 17 nM), enhances the transcription of HNF4α, and reduces the level of H4R3me2s.
T8548	Metoprine	7761-45-7	99.09%
T8548	Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.
T10882	CPUY074020	902279-44-1	99.07%
T10882	CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.