Histone Methyltransferase

Histone methyltransferases (HMT) are histone-modifying enzymes , that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues of histone proteins. The attachment of methyl groups occurs predominantly at specific lysine or arginine residues on histones H3 and H4.

Cat. No.	Product name	CAS No.	Purity
T8879	MR837	1210906-48-1	99.29%
T8879	MR837 (NSD2-PWWP1 antagonist 3f) is a NSD2-PWWP1 antagonist.
T6076	EPZ015666	1616391-65-1	99.29%
T6076	EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 enzymatic activity.
TQ0058	MI-463	1628317-18-9	99.28%
TQ0058	MI-463 is a potent and orally bioavailable inhibitor of the menin-mLL interaction (IC50: 15.3 nM).
T17204	UNC0321	1238673-32-9	99.25%
T17204	UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays. UNC0321 inhibits GLP ...
T40254	MRTX-1719	2630904-45-7	99.18%
T40254	MRTX-1719 is a potent, first-in-class, selective inhibitor of the PRMT5/MTA complex, with an IC50 of less than 10 nM in PRMT5/MTA MTAP DEL SDMA cells.
T7403	BAY-598	1906919-67-2	99.18%
T7403	BAY-598 is a selective inhibitor of SMYD2 with IC50 values of 27 nM.
T6809	CPI-169 racemate	1450655-76-1	99.14%
T6809	CPI-169 racemate (CPI 169) is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.
T11131	DW14800	2243709-60-4	99.12%
T11131	DW14800 is an inhibitor of PRMT5 (IC50 = 17 nM), enhances the transcription of HNF4α, and reduces the level of H4R3me2s.
T8548	Metoprine	7761-45-7	99.09%
T8548	Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.
T6333	MM-102	1417329-24-8	99.08%
T6333	MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic MLL1 inhibitor with IC50 of 0.4 μM.
T10882	CPUY074020	902279-44-1	99.07%
T10882	CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.
T28996	TP-064	2080306-20-1	99.07%
T28996	TP-064 is a potent and selective PRMT4 inhibitor. TP-064 includes inhibition of PRMT4 with IC50 < 10nM for methylation of H3 (1-25) and greater than 100-fold sel...
T9742	SETDB1-TTD-IN-1	2755823-12-0	99.05%
T9742	SETDB1-TTD-IN-1 is a potent, selective and endogenous binder competitive inhibitor of SETDB1-TTD with a Kd of 88 nM.
T17002	Tazemetostat hydrobromide	1467052-75-0	99.03%
T17002	Tazemetostat hydrobromide (E-7438 hydrobromide) is a potent and selective EZH2 inhibitor. Tazemetostat hydrobromide inhibits the activity of human polycomb repre...
T15194	EBI-2511	2098546-05-3	99.01%
T15194	EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).
T3081	EPZ004777	1338466-77-5	98.99%
T3081	EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.
T1959	BIX-01294 trihydrochloride	1392399-03-9	98.98%
T1959	BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.
T63351L	MS8511 HCl		98.90%
T63351L	MS8511 HCl is a selective and potent covalent inhibitor of G9a/GLP that acts by targeting cysteine residues in the substrate binding site. MS8511 has anticancer ...
T9969	EZM0414	2411748-50-8	98.9%
T9969	EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 with IC50 of 18 nM in SETD2 biochemical assay and IC50 of 34 nM in a cellular assay. EZM04...
T9399	Menin-MLL inhibitor 20	2448173-47-3	98.89%
T9399	Menin-MLL inhibitor 20 is an irreversible inhibitor of menin-MLL interaction with antitumor activities.