T3624 |
A-366
|
1527503-11-2
|
98.53%
|
|
A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than...
|
TQ0100 |
AZ505
|
1035227-43-0
|
98.48%
|
|
AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).
|
T9575 |
MRTX9768
|
2629314-68-5
|
98.48%
|
|
MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.
|
T3084 |
SGC707
|
1687736-54-4
|
98.45%
|
|
SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.
|
T8201 |
Gambogenic acid
|
173932-75-7
|
98.36%
|
|
Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity.
|
T6360 |
3-deazaneplanocin A HCl
|
120964-45-6
|
98.34%
|
|
3-deazaneplanocin A (DZNeP)HCl, an analog of adenosine, is a competitive inhibitor of S-adenosylhomocysteine hydrolase with Ki of 50 pM.
|
T60194 |
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(N-ethylcyclopropanecarboxamido)-4-methyl-4′-morpholino-[1,1′-biphenyl]-3-carboxamide
|
2238820-26-1
|
98.33%
|
|
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(N-ethylcyclopropanecarboxamido)-4-methyl-4′-morpholino-[1,1′-biphenyl]-3-carboxamide is a potent and se...
|
T13336 |
VTP50469
|
2169916-18-9
|
98.31%
|
|
VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
|
T6900 |
MS023
|
1831110-54-3
|
98.31%
|
|
MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, r...
|
T7194 |
CM-272
|
1846570-31-7
|
98.21%
|
|
CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
|
T12428L |
PF-06726304
|
1616287-82-1
|
98.19%
|
|
PF-06726304 shows robust antitumor growth activity. PF-06726304 is an effective and selective EZH2 inhibitor. PF-06726304 inhibits wild-type and Y641N mutant EZH...
|
T12344L1 |
OTS186935 FA
|
|
98.16%
|
|
OTS186935 FA is a protein methyltransferase SUV39H2 inhibitor.OTS186935 FA inhibits tumor growth in MDA-MB-231 breast cancer cells and A549 lung cancer cells.
|
T16886 |
Sinefungin
|
58944-73-3
|
98.12%
|
|
Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multipl...
|
T67697 |
WDR5-47
|
1422389-91-0
|
98.08%
|
|
WDR5-47 is a potent small molecule to disturb the interaction of MLL1-WDR5 with IC50 value of 0.3μM.
|
T27133 |
DCLX069
|
792946-69-1
|
98.06%
|
|
DCLX069 is a potent and selective PRMT1 inhibitor. DCLX069 occupies the SAM binding pocket to exert the inhibitory effect. DCLX069 effectively blocks cell prolif...
|
T40199 |
Tulmimetostat
|
2567686-02-4
|
98.04%
|
|
Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor.Tulmimetostat has antitumor activity and is used in the study of ovarian cancer and advanced sol...
|
T1868 |
JIB-04
|
199596-05-9
|
98.02%
|
|
JIB-04 (NSC 693627) is a pan-selective Jumonji histone demethylase inhibitor.
|
T7157 |
XY1
|
1624117-53-8
|
98%
|
|
XY1 is a very close analogue of SGC707 (a potent, selective, and non-competitive inhibitor of PRMT3 with IC50 of 31 nM), It is intended to be used as a negative...
|
T4021 |
UNC3866
|
1872382-47-2
|
98%
|
|
UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.
|
T7378 |
BRD9539
|
1374601-41-8
|
98%
|
|
BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μM
|