Home Tools
Log in
Cart

Histone Methyltransferase

Histone methyltransferases (HMT) are histone-modifying enzymes , that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues of histone proteins. The attachment of methyl groups occurs predominantly at specific lysine or arginine residues on histones H3 and H4.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T3624 A-366 1527503-11-2 98.53%
A-366
A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than...
TQ0100 AZ505 1035227-43-0 98.48%
AZ505
AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).
T9575 MRTX9768 2629314-68-5 98.48%
MRTX9768
MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.
T3084 SGC707 1687736-54-4 98.45%
SGC707
SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.
T8201 Gambogenic acid 173932-75-7 98.36%
Gambogenic acid
Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity.
T6360 3-deazaneplanocin A HCl 120964-45-6 98.34%
3-deazaneplanocin A HCl
3-deazaneplanocin A (DZNeP)HCl, an analog of adenosine, is a competitive inhibitor of S-adenosylhomocysteine hydrolase with Ki of 50 pM.
T60194 N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(N-ethylcyclopropanecarboxamido)-4-methyl-4′-morpholino-[1,1′-biphenyl]-3-carboxamide 2238820-26-1 98.33%
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(N-ethylcyclopropanecarboxamido)-4-methyl-4′-morpholino-[1,1′-biphenyl]-3-carboxamide
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(N-ethylcyclopropanecarboxamido)-4-methyl-4′-morpholino-[1,1′-biphenyl]-3-carboxamide is a potent and se...
T13336 VTP50469 2169916-18-9 98.31%
VTP50469
VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
T6900 MS023 1831110-54-3 98.31%
MS023
MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, r...
T7194 CM-272 1846570-31-7 98.21%
CM-272
CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
T12428L PF-06726304 1616287-82-1 98.19%
PF-06726304
PF-06726304 shows robust antitumor growth activity. PF-06726304 is an effective and selective EZH2 inhibitor. PF-06726304 inhibits wild-type and Y641N mutant EZH...
T12344L1 OTS186935 FA 98.16%
OTS186935 FA
OTS186935 FA is a protein methyltransferase SUV39H2 inhibitor.OTS186935 FA inhibits tumor growth in MDA-MB-231 breast cancer cells and A549 lung cancer cells.
T16886 Sinefungin 58944-73-3 98.12%
Sinefungin
Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multipl...
T67697 WDR5-47 1422389-91-0 98.08%
WDR5-47
WDR5-47 is a potent small molecule to disturb the interaction of MLL1-WDR5 with IC50 value of 0.3μM.
T27133 DCLX069 792946-69-1 98.06%
DCLX069
DCLX069 is a potent and selective PRMT1 inhibitor. DCLX069 occupies the SAM binding pocket to exert the inhibitory effect. DCLX069 effectively blocks cell prolif...
T40199 Tulmimetostat 2567686-02-4 98.04%
Tulmimetostat
Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor.Tulmimetostat has antitumor activity and is used in the study of ovarian cancer and advanced sol...
T1868 JIB-04 199596-05-9 98.02%
JIB-04
JIB-04 (NSC 693627) is a pan-selective Jumonji histone demethylase inhibitor.
T7157 XY1 1624117-53-8 98%
XY1
XY1 is a very close analogue of SGC707 (a potent, selective, and non-competitive inhibitor of PRMT3 with IC50 of 31 nM), It is intended to be used as a negative...
T4021 UNC3866 1872382-47-2 98%
UNC3866
UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.
T7378 BRD9539 1374601-41-8 98%
BRD9539
BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μM
A-366
T3624
A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than...
AZ505
TQ0100
AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).
MRTX9768
T9575
MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.
SGC707
T3084
SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.
Gambogenic acid
T8201
Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity.
3-deazaneplanocin A HCl
T6360
3-deazaneplanocin A (DZNeP)HCl, an analog of adenosine, is a competitive inhibitor of S-adenosylhomocysteine hydrolase with Ki of 50 pM.
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(N-ethylcyclopropanecarboxamido)-4-methyl-4′-morpholino-[1,1′-biphenyl]-3-carboxamide
T60194
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(N-ethylcyclopropanecarboxamido)-4-methyl-4′-morpholino-[1,1′-biphenyl]-3-carboxamide is a potent and se...
VTP50469
T13336
VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
MS023
T6900
MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, r...
CM-272
T7194
CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
PF-06726304
T12428L
PF-06726304 shows robust antitumor growth activity. PF-06726304 is an effective and selective EZH2 inhibitor. PF-06726304 inhibits wild-type and Y641N mutant EZH...
OTS186935 FA
T12344L1
OTS186935 FA is a protein methyltransferase SUV39H2 inhibitor.OTS186935 FA inhibits tumor growth in MDA-MB-231 breast cancer cells and A549 lung cancer cells.
Sinefungin
T16886
Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multipl...
WDR5-47
T67697
WDR5-47 is a potent small molecule to disturb the interaction of MLL1-WDR5 with IC50 value of 0.3μM.
DCLX069
T27133
DCLX069 is a potent and selective PRMT1 inhibitor. DCLX069 occupies the SAM binding pocket to exert the inhibitory effect. DCLX069 effectively blocks cell prolif...
Tulmimetostat
T40199
Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor.Tulmimetostat has antitumor activity and is used in the study of ovarian cancer and advanced sol...
JIB-04
T1868
JIB-04 (NSC 693627) is a pan-selective Jumonji histone demethylase inhibitor.
XY1
T7157
XY1 is a very close analogue of SGC707 (a potent, selective, and non-competitive inhibitor of PRMT3 with IC50 of 31 nM), It is intended to be used as a negative...
UNC3866
T4021
UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.
BRD9539
T7378
BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μM
1 2 3 4 5 6 7 8 9 10
TargetMol