Histone Methyltransferase

Histone methyltransferases (HMT) are histone-modifying enzymes , that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues of histone proteins. The attachment of methyl groups occurs predominantly at specific lysine or arginine residues on histones H3 and H4.

Cat. No.	Product name	CAS No.	Purity
T13780	MS1943	2225938-17-8	98.26%
T13780	MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).
T7194	CM-272	1846570-31-7	98.21%
T7194	CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
T12428L	PF-06726304	1616287-82-1	98.19%
T12428L	PF-06726304 shows robust antitumor growth activity. PF-06726304 is an effective and selective EZH2 inhibitor. PF-06726304 inhibits wild-type and Y641N mutant EZH...
T12344L1	OTS186935 FA		98.16%
T12344L1	OTS186935 FA is a protein methyltransferase SUV39H2 inhibitor.OTS186935 FA inhibits tumor growth in MDA-MB-231 breast cancer cells and A549 lung cancer cells.
T7305	JQEZ5	1913252-04-6	98.14%
T7305	JQEZ5 is an inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM).
T16886	Sinefungin	58944-73-3	98.12%
T16886	Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multipl...
T67697	WDR5-47	1422389-91-0	98.08%
T67697	WDR5-47 is a potent small molecule to disturb the interaction of MLL1-WDR5 with IC50 value of 0.3μM.
T27133	DCLX069	792946-69-1	98.06%
T27133	DCLX069 is a potent and selective PRMT1 inhibitor. DCLX069 occupies the SAM binding pocket to exert the inhibitory effect. DCLX069 effectively blocks cell prolif...
T40199	Tulmimetostat	2567686-02-4	98.04%
T40199	Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor.Tulmimetostat has antitumor activity and is used in the study of ovarian cancer and advanced sol...
T1868	JIB-04	199596-05-9	98.02%
T1868	JIB-04 (NSC 693627) is a pan-selective Jumonji histone demethylase inhibitor.
T7157	XY1	1624117-53-8	98%
T7157	XY1 is a very close analogue of SGC707 (a potent, selective, and non-competitive inhibitor of PRMT3 with IC50 of 31 nM), It is intended to be used as a negative...
T7378	BRD9539	1374601-41-8	98%
T7378	BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μM
T4378	MS049	1502816-23-0	98%
T4378	MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.
T72979	LEM-14-1189	2987501-17-5	97.98%
T72979	Lem-14-1189, a LEM-14 derivative, is a potent NSD inhibitor of the nuclear receptor binding SET domain, and has inhibitory effects on NSD1, NSD2, and NSD3, with ...
TQ0263	EPZ031686	1808011-22-4	97.91%
TQ0263	EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer.
T12430	PF-06821497	1844849-10-0	97.88%
T12430	PF-06821497 is a selective inhibitor of EZH2 with significant tumor growth inhibition.
T10205	A-395	2089148-72-9	97.82%
T10205	A-395 is an antagonist of polycomb repressive complex 2 (PRC2) protein-protein interactions that potently inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12, IC5...
T8838	CCI-007	939228-52-1	97.81%
T8838	CCI 007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485
T17203	UNC0224	1197196-48-7	97.61%
T17203	UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.
T60777	EM127	1886879-71-5	97.61%
T60777	EM127 is a highly selective and potent covalent inhibitor of SMYD3 with a KD value of 13 μM.EM127 inhibits ERK1/2 phosphorylation and inhibits transcriptional re...