IκB/IKK

The IκB kinase (IKK) is an enzyme complex that is involved in propagating the cellular response to inflammation.The IκB kinase enzyme complex is part of the upstream NF-κB signal transduction cascade. The IκBα (inhibitor of nuclear factor kappa B) protein inactivates the NF-κB transcription factor by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm. Specifically, IKK phosphorylates the inhibitory IκBα protein. This phosphorylation results in the dissociation of IκBα from NF-κB. NF-κB, which is now free, migrates into the nucleus and activates the expression of at least 150 genes; some of which are anti-apoptotic.

Cat. No.	Product name	CAS No.	Purity
T3094	PS-1145	431898-65-6	99.63%
T3094	PS-1145 (IKK Inhibitor X) is a specific IKK inhibitor with IC50 of 88 nM.
T6176	IKK 16	873225-46-8	99.61%
T6176	IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
T6141	IMD-0354	978-62-1	99.56%
T6141	IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.
T1639	Amlexanox	68302-57-8	99.55%
T1639	Amlexanox (AA673) is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, f...
T8910	2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC	4815-35-4	99.44%
T8910	2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC is Inhibitior of IKKβ.
T1934	Bay 11-7085	196309-76-9	99.43%
T1934	Bay 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).
T6771	AZD3264	1609281-86-8	99.42%
T6771	AZD3264 is a new type IKK2 inhibitor.
T10477	BAY-985	2409479-29-2	99.3%
T10477	BAY-985 is a potent, selective, and orally active ATP-competitive dual inhibitor of TBK1 and IKKε (IC50s: 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε) with an...
T9105	NF-κB-IN-1	1227098-15-8	99.29%
T9105	NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathway inhib...
T3049	TPCA-1	507475-17-4	99.29%
T3049	TPCA-1 (TPCA1) is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinases ...
T6186	TRAM-34	289905-88-0	99.01%
T6186	TRAM-34 (Triarylmethane-34) (Kd=20 nM), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1), does not b...
T6165	Bardoxolone Methyl	218600-53-4	98.94%
T6165	Bardoxolone Methyl (TP-155) is a synthetic triterpenoid that acts as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway with potential anti-t...
TQ0306	MLN120B	783348-36-7	98.86%
TQ0306	MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).
T15559	TBK1/IKKε-IN-2	1292310-49-6	98.77%
T15559	TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.
T2055	WS3	1421227-52-2	98.77%
T2055	WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
T22021	ACHP	406208-42-2	98.66%
T22021	ACHP (IKK-2 Inhibitor VIII) is a novel selective and potent IKK inhibitor with inhibitory effects on IKK-α and IKK-β. ACHP has anti-HIV-1 activity and inhibits H...
T7081	CCCP	555-60-2	98.55%
T7081	CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the ...
T5162	MRT67307 HCl (1190378-57-4(free base))	T5162	98.52%
T5162	MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).
T1830	BX795	702675-74-9	98.32%
T1830	BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respect...
T2765	Rosmarinic acid	20283-92-5	98.19%
T2765	Rosmarinic acid (Labiatenic acid) is widely found in plants and has antioxidant, anti-inflammatory, and antibacterial activities. It inhibits MAO-A, MAO-B, and C...