T15032 |
CYM50308
|
1345858-76-5
|
99.43%
|
|
CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes ...
|
T3258 |
Ponesimod
|
854107-55-4
|
99.42%
|
|
Ponesimod (ACT-128800) is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist with potential immunomodulating activity.
|
T63047 |
SLP9101555
|
T63047
|
99.40%
|
|
SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher...
|
T2539 |
Fingolimod hydrochloride
|
162359-56-0
|
99.29%
|
|
Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
|
TQ0227 |
Etrasimod
|
1206123-37-6
|
99.17%
|
|
Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells).
|
T28169 |
NIBR-0213
|
1233332-14-3
|
98.87%
|
|
NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis.
|
T22703 |
CYM-5520
|
1449747-00-5
|
98.72%
|
|
CYM-5520 is a noncompetitive allosteric agonist of S1P2
|
T4016 |
BMS-986020
|
1257213-50-5
|
98.61%
|
|
BMS-986020 (AM152) is a selective antagonist of LPA1.
|
T61112 |
SLF1081851
|
2763730-97-6
|
98.57%
|
|
SLF1081851 is a Spns2 inhibitor. SLF1081851 inhibits S1P release with IC50 of 1.93 μM.
|
T6108 |
Ki16425
|
355025-24-0
|
98.54%
|
|
Ki16425 (Debio 0719) is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively.
|
T9199 |
GLPG2938
|
2130996-00-6
|
98.1%
|
|
GLPG2938 (1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea) is a potent and s...
|
T6403 |
Siponimod
|
1230487-00-9
|
97.79%
|
|
BAF312 (Siponimod (BAF-312)), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. T...
|
T7360 |
GSK2018682
|
1034688-30-6
|
97.78%
|
|
GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
|
T6347 |
Ki16198
|
355025-13-7
|
97.6%
|
|
Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μ...
|
T3961 |
CYM-5541
|
945128-26-7
|
97.34%
|
|
CYM-5541 (ML249) is a selective and allosteric S1P3 receptor agonist.
|
T2026 |
CYM5442
|
1094042-01-9
|
96.65%
|
|
CYM5442 is an S1P agonist, targeting to Sphingosine.
|
T7393 |
ONO-7300243
|
638132-34-0
|
|
|
ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 µM).
|
T15629 |
JTE-013
|
383150-41-2
|
|
|
JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 n...
|
T0307 |
Tyloxapol
|
25301-02-4
|
98%
|
|
Tyloxapol (Triton WR1339) is a non-ionic liquid polymer used as a surfactant.
|
T21500 |
Sphingosine-1-phosphate
|
26993-30-6
|
98%
|
|
Sphingosine-1-phosphate (S1P) is an agonist for S1P1-5 receptors and a ligand for GPR3, GPR6, GPR12.Sphingosine-1-phosphate is an intracellular second messenger ...
|