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LPL Receptor

The lysophospholipid receptor (LPL-R) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling. In humans, there are eight LPL receptors, each encoded by a separate gene. These LPL receptor genes are also sometimes referred to as "Edg" (an acronym for endothelial differentiation gene).
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T15032 CYM50308 1345858-76-5 99.43%
CYM50308
CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes ...
T3258 Ponesimod 854107-55-4 99.42%
Ponesimod
Ponesimod (ACT-128800) is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist with potential immunomodulating activity.
T63047 SLP9101555 T63047 99.40%
SLP9101555
SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher...
T2539 Fingolimod hydrochloride 162359-56-0 99.29%
Fingolimod hydrochloride
Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
TQ0227 Etrasimod 1206123-37-6 99.17%
Etrasimod
Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells).
T28169 NIBR-0213 1233332-14-3 98.87%
NIBR-0213
NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis.
T22703 CYM-5520 1449747-00-5 98.72%
CYM-5520
CYM-5520 is a noncompetitive allosteric agonist of S1P2
T4016 BMS-986020 1257213-50-5 98.61%
BMS-986020
BMS-986020 (AM152) is a selective antagonist of LPA1.
T61112 SLF1081851 2763730-97-6 98.57%
SLF1081851
SLF1081851 is a Spns2 inhibitor. SLF1081851 inhibits S1P release with IC50 of 1.93 μM.
T6108 Ki16425 355025-24-0 98.54%
Ki16425
Ki16425 (Debio 0719) is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively.
T9199 GLPG2938 2130996-00-6 98.1%
GLPG2938
GLPG2938 (1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea) is a potent and s...
T6403 Siponimod 1230487-00-9 97.79%
Siponimod
BAF312 (Siponimod (BAF-312)), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. T...
T7360 GSK2018682 1034688-30-6 97.78%
GSK2018682
GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
T6347 Ki16198 355025-13-7 97.6%
Ki16198
Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μ...
T3961 CYM-5541 945128-26-7 97.34%
CYM-5541
CYM-5541 (ML249) is a selective and allosteric S1P3 receptor agonist.
T2026 CYM5442 1094042-01-9 96.65%
CYM5442
CYM5442 is an S1P agonist, targeting to Sphingosine.
T7393 ONO-7300243 638132-34-0
ONO-7300243
ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 µM).
T15629 JTE-013 383150-41-2
JTE-013
JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 n...
T0307 Tyloxapol 25301-02-4 98%
Tyloxapol
Tyloxapol (Triton WR1339) is a non-ionic liquid polymer used as a surfactant.
T21500 Sphingosine-1-phosphate 26993-30-6 98%
Sphingosine-1-phosphate
Sphingosine-1-phosphate (S1P) is an agonist for S1P1-5 receptors and a ligand for GPR3, GPR6, GPR12.Sphingosine-1-phosphate is an intracellular second messenger ...
CYM50308
T15032
CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes ...
Ponesimod
T3258
Ponesimod (ACT-128800) is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist with potential immunomodulating activity.
SLP9101555
T63047
SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher...
Fingolimod hydrochloride
T2539
Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
Etrasimod
TQ0227
Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells).
NIBR-0213
T28169
NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis.
CYM-5520
T22703
CYM-5520 is a noncompetitive allosteric agonist of S1P2
BMS-986020
T4016
BMS-986020 (AM152) is a selective antagonist of LPA1.
SLF1081851
T61112
SLF1081851 is a Spns2 inhibitor. SLF1081851 inhibits S1P release with IC50 of 1.93 μM.
Ki16425
T6108
Ki16425 (Debio 0719) is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively.
GLPG2938
T9199
GLPG2938 (1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea) is a potent and s...
Siponimod
T6403
BAF312 (Siponimod (BAF-312)), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. T...
GSK2018682
T7360
GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
Ki16198
T6347
Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μ...
CYM-5541
T3961
CYM-5541 (ML249) is a selective and allosteric S1P3 receptor agonist.
CYM5442
T2026
CYM5442 is an S1P agonist, targeting to Sphingosine.
ONO-7300243
T7393
ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 µM).
JTE-013
T15629
JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 n...
Tyloxapol
T0307
Tyloxapol (Triton WR1339) is a non-ionic liquid polymer used as a surfactant.
Sphingosine-1-phosphate
T21500
Sphingosine-1-phosphate (S1P) is an agonist for S1P1-5 receptors and a ligand for GPR3, GPR6, GPR12.Sphingosine-1-phosphate is an intracellular second messenger ...
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TargetMol