MEK

MEK is a member of the MAPK signaling cascade that is activated in melanoma. When MEK is inhibited, cell proliferation is blocked and apoptosis (controlled cell death) is induced.

Cat. No.	Product name	CAS No.	Purity
T2P2806	Hederacolchiside A1	106577-39-3	99.92%
T2P2806	Hederacolchiside A1 (Raddeanoside R13) shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the paras...
T6189	Mirdametinib	391210-10-9	99.91%
T6189	Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity. Mirdametinib exhibits antitumor activity by in...
T2125	Trametinib	871700-17-3	99.88%
T2125	Trametinib (GSK1120212) is a MEK inhibitor that inhibits MEK1 and MEK2 (IC50=0.7/0.9 nM) with ATP non-competitive and oral activity. Trametinib activates autopha...
T3001	Honokiol	35354-74-6	99.87%
T3001	Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.
T2416	BIX02189	1094614-85-3	99.86%
T2416	BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.
T6636	Refametinib	923032-37-5	99.84%
T6636	Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).
T1144	Lidocaine hydrochloride	73-78-9	99.83%
T1144	Lidocaine hydrochloride (Lignocaine hydrochloride) is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and...
T7030	Anemarsaponin B	139051-27-7	99.81%
T7030	Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity,...
T6152	PD318088	391210-00-7	99.81%
T6152	PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-bi...
T21980	PD 198306	212631-61-3	99.75%
T21980	PD 198306 is a selective inhibitor of MAPK/ERK-kinase (MEK) with antihyperalgesic effects. PD 198306 reduces the Streptozocin-induced increase in the level of ac...
T0468	Lidocaine	137-58-6	99.74%
T0468	Lidocaine (Alphacaine) is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation o...
T9321	Zapnometinib	303175-44-2	99.66%
T9321	Zapnometinib (ATR-002) is a MEK inhibitor.
T16114	Pavinetant	941690-55-7	99.60%
T16114	Pavinetant is a small molecule orally active and selective neurokinin-3 (NK3) receptor antagonist for the treatment of hot flashes and polycystic ovarian syndrom...
T6692	TAK-733	1035555-63-5	99.53%
T6692	TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.
T12697	Refametinib R enantiomer	923032-38-6	99.43%
T12697	Refametinib R enantiomer (RDEA119 R enantiomer) is an MEK inhibitor with an EC50 of 2.0-15 nM.Refametinib (R enantiomer) has anticancer activity and can be used ...
T36631	BAY-6035	2247890-13-5	99.39%
T36631	BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3). BAY-6035 has more than 100-fold selectivity over other histone methyltransferases.
T7610	GW284543	790186-68-4	99.38%
T7610	GW284543 (UNC10225170) is a selective inhibitor of MEK5 .
T6057	URMC-099	1229582-33-5	99.32%
T6057	URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
T28012	MEK-IN-4	297744-42-4	99.26%
T28012	MEK-IN-4 is a MEK inhibitor that can be used to study inflammatory diseases and cancer.
T6324	(E/Z)-BIX02188	1094614-84-2	99.21%
T6324	BIX02188 is a specific MEK5 inhibitor (IC50: 4.3 nM), also inhibits ERK5 catalytic activity (IC50: 810 nM), and does not inhibit closely related kinases MEK1/2, ...