NMDAR

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. The NMDA receptor is one of three types of ionotropic glutamate receptors. The other receptors are the AMPA and kainate receptors. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. The NMDA receptor is very important for controlling synaptic plasticity and memory function.The NMDAR is a specific type of ionotropic glutamate receptor. The NMDA receptor is so named because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to other glutamate receptors. Activation of NMDA receptors results in the opening of an ion channel that is nonselective to cations, with a combined reversal potential near 0 mV. While the opening and closing of the ion channel is primarily gated by ligand binding, the current flow through the ion channel is voltage dependent. Extracellular magnesium (Mg2+) and zinc (Zn2+) ions can bind to specific sites on the receptor, blocking the passage of other cations through the open ion channel. Depolarization of the cell dislodges and repels the Mg2+ and Zn2+ ions from the pore, thus allowing a voltage-dependent flow of sodium (Na+) and small amounts of calcium (Ca2+) ions into the cell and potassium (K+) out of the cell.

Cat. No.	Product name	CAS No.	Purity
T1751	Eliprodil	119431-25-3	99.77%
T1751	Eliprodil (SL-820715)(SL-820715), a non-competitive NR2B-NMDA receptor antagonist(IC50: 1 uM), less effective for NR2A- and NR2C-containing receptors(IC50> 100 u...
T22583	Arcaine sulfate	14923-17-2	99.77%
T22583	Arcaine sulfate is a NMDA antagonist.
T17293	ZL006	1181226-02-7	99.75%
T17293	ZL006 is an effective inhibitor of nNOS/PSD-95 interaction. ZL006 also inhibits NMDA receptor-mediated NO synthesis.
T4885	(-)-Aspartic acid	1783-96-6	99.74%
T4885	(-)-Aspartic acid (L-Homoproline) is an endogenous amino acid existing in invertebrates and vertebrates. It can regulate testosterone synthesis and is an agonist...
T10191L	7-Chlorokynurenic acid	18000-24-3	99.72%
T10191L	7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B c...
TQ0279	Ibotenic acid	2552-55-8	99.70%
TQ0279	Ibotenic acid (RS-42358-197) has agonist activity at both the NMDA and trans-ACPD or metabotropic quisqualate receptors.
T1186	Ifenprodil Tartrate	23210-58-4	99.7%
T1186	Ifenprodil is a selective NMDA receptor (glutamate) antagonist.
T65135	Kynurenic acid	492-27-3	99.69%
T65135	Kynurenic acid (Quinurenic acid) is an endogenous tryptophan active metabolite, a triple antagonist of NMDA, glutamate, α7 nicotinic acetylcholine receptor, and ...
T10781	CGP 78608 hydrochloride	1135278-54-4	99.68%
T10781	CGP 78608 hydrochloride is a specific antagonist at the glycine binding site of the NMDA receptor (IC50 = 6 nM). CGP 78608 hydrochloride exhibits anticonvulsant ...
T3407	Rapastinel	117928-94-6	99.67%
T3407	Rapastinel (TPPT-amide) (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator.
T2362	QNZ46	1237744-13-6	99.64%
T2362	QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist.
T0051	Urethane	51-79-6	99.63%
T0051	Urethane (Ethylurethane) was an antineoplastic agent .Now is used for other medicinal purposes.
T64344	N-Methyl-DL-aspartic acid	17833-53-3	99.62%
T64344	N-Methyl-DL-aspartic acid, a glutamate analogue and NMDA receptor agonist, is utilized in neurological disease research.
T3407L	Rapastinel acetate	491872-39-0	99.6%
T3407L	Rapastinel acetate is a modulator of N-methyl-D-aspartate (NMDA) receptor and a partial agonist of glycine site long-lasting antidepressant effects.
T22517	5,7-Dichlorokynurenic acid	131123-76-7	99.56%
T22517	5,7-Dichlorokynurenic acid (5,7-dichlorokynurenic acid sodium) is an NMDA receptor antagonist.
T1308	Orphenadrine hydrochloride	341-69-5	99.54%
T1308	Orphenadrine hydrochloride (Mephenamin) is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
T22513	4-PPBP maleate	201216-39-9	99.54%
T22513	4-PPBP maleate is a potent σ1 receptor (ligand) agonist. 4-PPBP maleate can be considered a selective, non-competitive NR1a/2B NMDA receptor antagonist in the co...
T10852	CNS-5161 hydrochloride	160756-38-7	99.53%
T10852	CNS-5161 hydrochloride (CNS 5161A) is a new antagonist of NMDA ion-channel. It interacts with the NMDA receptor/ion channel site to produce a noncompetitive bloc...
T8626	Transtorine	13593-94-7	99.49%
T8626	Transtorine (1,4-DIHYDRO-4-OXOQUINOLINE-2-CARBOXYLIC ACID) is a GluR and NMDA inhibitor.
T14971	CIQ	486427-17-2	99.47%
T14971	CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. EC50 value: 2.7 μM for NR2C and 2.8 μM for NR2D.