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NMDAR

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. The NMDA receptor is one of three types of ionotropic glutamate receptors. The other receptors are the AMPA and kainate receptors. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. The NMDA receptor is very important for controlling synaptic plasticity and memory function.The NMDAR is a specific type of ionotropic glutamate receptor. The NMDA receptor is so named because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to other glutamate receptors. Activation of NMDA receptors results in the opening of an ion channel that is nonselective to cations, with a combined reversal potential near 0 mV. While the opening and closing of the ion channel is primarily gated by ligand binding, the current flow through the ion channel is voltage dependent. Extracellular magnesium (Mg2+) and zinc (Zn2+) ions can bind to specific sites on the receptor, blocking the passage of other cations through the open ion channel. Depolarization of the cell dislodges and repels the Mg2+ and Zn2+ ions from the pore, thus allowing a voltage-dependent flow of sodium (Na+) and small amounts of calcium (Ca2+) ions into the cell and potassium (K+) out of the cell.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T22798 Gavestinel 153436-38-5 99.04%
Gavestinel
Gavestinel (GV 150526) is a non-competitive NMDA receptor antagonist that is potent, selective and orally active.Gavestinel binds to the glycine site of the NMDA...
T72059 S1R agonist 2 150085-21-5 99.04%
S1R agonist 2
S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.
T0556 6-Methoxy-2-naphthoic acid 2471-70-7 99.03%
6-Methoxy-2-naphthoic acid
6-Methoxy-2-naphthoic acid (6-Methoxy-2-naphthalenecarboxylic acid) is an modulator of NMDAR.
T8394 D-Serine 312-84-5 99%
D-Serine
D-Serine ((R)-Serine) is an endogenous amino acid,is a potent co-agonist at the NMDA glutamate receptor.
T7870 TCN 201 852918-02-6 98.97%
TCN 201
TCN 201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
T3486 3-MATIDA 518357-51-2 98.92%
3-MATIDA
3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGluR-4...
T60237 L-Cysteine S-sulfate 1637-71-4 98.92%
L-Cysteine S-sulfate
L-Cysteine S-sulfate (S-Sulfo-L-cysteine) is an effective N-methyl-d-aspartate (NMDA) glutamatergic receptors agonist. L-Cysteine S-sulfate is the substrate for ...
T72662 NMDAR/TRPM4-IN-2 2243506-33-2 98.77%
NMDAR/TRPM4-IN-2
NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retina...
T8351 UBP551 89-35-0 98.77%
UBP551
UBP551 is a potent and selective NMDA receptors modulator.
T22748 DQP 1105 380560-89-4 98.77%
DQP 1105
DQP 1105 is a NMDA receptor antagonist.
T28367L1 BDBM50597431 1629853-49-1 98.64%
BDBM50597431
BDBM50597431 is an NMDA receptor modulator that may have can be used to study Alzheimer's disease and Parkinson's syndrome.
T23048 N20C hydrochloride 1177583-87-7 98.58%
N20C hydrochloride
N20C hydrochloride (2-((3,3-diphenylpropyl)amino)acetamide hydrochloride) is a non-competitive NMDA receptor open-channel blocker.
T22900 L-701252 151057-13-5 98.53%
L-701252
L-701252 is a potent antagonist of glycine site NMDA receptor with an IC50 of 420 nM. L-701252 provides a small degree of neuroprotection in global cerebral isch...
T22674 Co 101244 hydrochloride 193356-17-1 98.44%
Co 101244 hydrochloride
Co 101244 hydrochloride (4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride) is an NR2B-containing NMDA receptor antagonist.
T24918 UBP710 1333111-40-2 98.39%
UBP710
UBP710 is an effective and selective NMDA receptor modulator.
T13248 UK-240455 178908-09-3 98.34%
UK-240455
UK-240455 is a potent and selective N-methyl-D-aspartic acid (NMDA) glycine receptor antagonist with neuroprotective effects and improved motor function in Parki...
T26686 AV-101 153152-32-0 98.27%
AV-101
AV-101 (4-Cl-KYN) , a prodrug antagonist at the glycine site of the NMDA receptor, has antidepressant activity and reduces levodopa-induced dyskinesia in MPTP mo...
T27606 Indantadol HCl 202914-18-9 98.24%
Indantadol HCl
Indantadol HCl (CHF-3381) is a NMDA antagonist and nonselective MAO inhibitor.
T1324 O-Phospho-L-serine 407-41-0 98.23%
O-Phospho-L-serine
O-Phospho-L-serine (Phosphoserine) is the phosphoric acid ester of serine.
T62839 Dalzanemdor 1629853-48-0 98.20%
Dalzanemdor
Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dys...
Gavestinel
T22798
Gavestinel (GV 150526) is a non-competitive NMDA receptor antagonist that is potent, selective and orally active.Gavestinel binds to the glycine site of the NMDA...
S1R agonist 2
T72059
S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.
6-Methoxy-2-naphthoic acid
T0556
6-Methoxy-2-naphthoic acid (6-Methoxy-2-naphthalenecarboxylic acid) is an modulator of NMDAR.
D-Serine
T8394
D-Serine ((R)-Serine) is an endogenous amino acid,is a potent co-agonist at the NMDA glutamate receptor.
TCN 201
T7870
TCN 201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
3-MATIDA
T3486
3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGluR-4...
L-Cysteine S-sulfate
T60237
L-Cysteine S-sulfate (S-Sulfo-L-cysteine) is an effective N-methyl-d-aspartate (NMDA) glutamatergic receptors agonist. L-Cysteine S-sulfate is the substrate for ...
NMDAR/TRPM4-IN-2
T72662
NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retina...
UBP551
T8351
UBP551 is a potent and selective NMDA receptors modulator.
DQP 1105
T22748
DQP 1105 is a NMDA receptor antagonist.
BDBM50597431
T28367L1
BDBM50597431 is an NMDA receptor modulator that may have can be used to study Alzheimer's disease and Parkinson's syndrome.
N20C hydrochloride
T23048
N20C hydrochloride (2-((3,3-diphenylpropyl)amino)acetamide hydrochloride) is a non-competitive NMDA receptor open-channel blocker.
L-701252
T22900
L-701252 is a potent antagonist of glycine site NMDA receptor with an IC50 of 420 nM. L-701252 provides a small degree of neuroprotection in global cerebral isch...
Co 101244 hydrochloride
T22674
Co 101244 hydrochloride (4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride) is an NR2B-containing NMDA receptor antagonist.
UBP710
T24918
UBP710 is an effective and selective NMDA receptor modulator.
UK-240455
T13248
UK-240455 is a potent and selective N-methyl-D-aspartic acid (NMDA) glycine receptor antagonist with neuroprotective effects and improved motor function in Parki...
AV-101
T26686
AV-101 (4-Cl-KYN) , a prodrug antagonist at the glycine site of the NMDA receptor, has antidepressant activity and reduces levodopa-induced dyskinesia in MPTP mo...
Indantadol HCl
T27606
Indantadol HCl (CHF-3381) is a NMDA antagonist and nonselective MAO inhibitor.
O-Phospho-L-serine
T1324
O-Phospho-L-serine (Phosphoserine) is the phosphoric acid ester of serine.
Dalzanemdor
T62839
Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dys...
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TargetMol