NMDAR

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. The NMDA receptor is one of three types of ionotropic glutamate receptors. The other receptors are the AMPA and kainate receptors. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. The NMDA receptor is very important for controlling synaptic plasticity and memory function.The NMDAR is a specific type of ionotropic glutamate receptor. The NMDA receptor is so named because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to other glutamate receptors. Activation of NMDA receptors results in the opening of an ion channel that is nonselective to cations, with a combined reversal potential near 0 mV. While the opening and closing of the ion channel is primarily gated by ligand binding, the current flow through the ion channel is voltage dependent. Extracellular magnesium (Mg2+) and zinc (Zn2+) ions can bind to specific sites on the receptor, blocking the passage of other cations through the open ion channel. Depolarization of the cell dislodges and repels the Mg2+ and Zn2+ ions from the pore, thus allowing a voltage-dependent flow of sodium (Na+) and small amounts of calcium (Ca2+) ions into the cell and potassium (K+) out of the cell.

Cat. No.	Product name	CAS No.	Purity
T22748	DQP 1105	380560-89-4	98.77%
T22748	DQP 1105 is a NMDA receptor antagonist.
T28367L1	BDBM50597431	1629853-49-1	98.64%
T28367L1	BDBM50597431 is an NMDA receptor modulator that may have can be used to study Alzheimer's disease and Parkinson's syndrome.
T23048	N20C hydrochloride	1177583-87-7	98.58%
T23048	N20C hydrochloride (2-((3,3-diphenylpropyl)amino)acetamide hydrochloride) is a non-competitive NMDA receptor open-channel blocker.
T22900	L-701252	151057-13-5	98.53%
T22900	L-701252, a potent glycine site NMDA receptor antagonist, exhibits an inhibition concentration (IC50) of 420 nM. Additionally, it offers marginal neuroprotection...
T22674	Co 101244 hydrochloride	193356-17-1	98.44%
T22674	Co 101244 hydrochloride (4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride) is an NR2B-containing NMDA receptor antagonist.
T24918	UBP710	1333111-40-2	98.39%
T24918	UBP710 is an effective and selective NMDA receptor modulator.
T9133	Caroverine hydrochloride	55750-05-5	98.37%
T9133	Caroverine hydrochloride (Caroverine HCL) is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It is also an antioxidant and c...
T13248	UK-240455	178908-09-3	98.34%
T13248	UK-240455 is a potent and selective N-methyl-D-aspartic acid (NMDA) glycine receptor antagonist with neuroprotective effects and improved motor function in Parki...
T26686	AV-101	153152-32-0	98.27%
T26686	AV-101 (4-Cl-KYN) , a prodrug antagonist at the glycine site of the NMDA receptor, has antidepressant activity and reduces levodopa-induced dyskinesia in MPTP mo...
T27606	Indantadol HCl	202914-18-9	98.24%
T27606	Indantadol HCl (CHF-3381) is a NMDA antagonist and nonselective MAO inhibitor.
T62839	Dalzanemdor	1629853-48-0	98.20%
T62839	Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dys...
T12110	MRZ 2-514	202808-11-5	98.13%
T12110	MRZ 2-514 (8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one) is a strychnine-insensitive modulatory site of the NMDA receptor (glycineB)antagonist with Ki of...
T9626	Cycloleucine	52-52-8	98.13%
T9626	Cycloleucine is an antagonist of NMDA receptor associated glycine receptor with a Ki of 600 μM. Cycloleucine is also a competitive inhibitor of S-adenosyl-methio...
T1909	L-701324	142326-59-8	98%
T1909	L-701324 is an NMDA receptor with high affinity and selectivity for the glycine site, used as an orally active and long-acting anticonvulsant.
T0802	Procaine hydrochloride	51-05-8	98%
T0802	Procaine hydrochloride (Novocaine HCl) is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties....
T7778	Glypromate	32302-76-4	98%
T7778	Glypromate (Gly-Pro-Glu) is a neuroprotective agent, is a weak NMDA receptor agonist
TN1432	Bacopasaponin C	178064-13-6	97.85%
TN1432	Bacopasaponin C may have antioxidant activity, it also shows anti-leishmanial property.
T12234	NMDA-IN-1	700878-19-9	97.01%
T12234	NMDA-IN-1 is a potent and NR2B-selective antagonist of NMDA(NMDA Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM).
T11516	GV-196771A	166974-23-8	96.43%
T11516	GV-196771A A novel NMDA receptor glycine site antagonist with potent antinociceptive activity.
T16801	(RS)-(Tetrazol-5-yl)glycine	138199-51-6	95.00%
T16801	(RS)-(Tetrazol-5-yl)glycine (LY 285265) (D,L-(tetrazol-5-yl)glycine) is an effective and selective N-methyl-D-aspartate receptor agonist. (RS)-(Tetrazol-5-yl)gly...