NOS

Nitric oxide synthases(NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS).

Cat. No.	Product name	CAS No.	Purity
T7474	7-Nitroindazole	2942-42-9	96.15%
T7474	7-Nitroindazole is a non-selective inhibitor of NOS isoforms in vitro for neuronal nitric oxide synthase showing a 10-fold selectivity for neuronal NOS.
TN1576	Diallyl disulfide	2179-57-9	95%
TN1576	Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.
T0358	Aminoguanidine hydrochloride	1937-19-5	100%
T0358	Aminoguanidine hydrochloride (Hydrazinecarboximidamide) is a diamine oxidase and NO synthase inhibitor, used in the treatment of diabetic nephropathy.
T22724	Dimaprit dihydrochloride	23256-33-9	100%
T22724	Dimaprit dihydrochloride is a selective histamine H2 receptor agonist. Dimaprit dihydrochloride also inhibits nNOS with an IC50 of 49 μM. It can stimulate gastri...
T21700	NOS-IN-1	165383-72-2	100%
T21700	NOS-IN-1 (2-Imino-4-methylpiperidine acetate) is a potent and orally active inhibitor of NO synthase (NOS) isoforms. NOS-IN-1 exhibits IC50s of 0.1 μM, 0.2 μM, a...
T3491	1400W dihydrochloride	214358-33-5	100%
T3491	1400W dihydrochloride (N-(3-(Aminomethyl)benzyl)acetamidine) is a highly effective and specific inhibitor of inducible NOS2 (iNOS).
T7206L	2-Iminobiotin hydrobromide	76985-52-9
T7206L	2-Iminobiotin hydrobromide (Guanidinobiotin) is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS)...
T22419	S-Methylisothiourea sulfate	867-44-7
T22419	S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) is a potent and selective inhibitor of iNOS and exerts beneficial effects in rodent models of septic ...
T3426	Bacoside A	11028-00-5
T3426	Bacoside A has a possible anticancer activity that could be inducing cell cycle arrest and apoptosis through Notch pathway in GBM in vitro. It exerts cytoprotect...
TN1599	Eburicoic acid	560-66-7	98%
TN1599	Eburicoic acid (ZINC4655149) exhibits anti-inflammatory and antioxidant activity thereby protecting the liver from CCl4-induced hepatic damage and can be used in...
T15697	L-NMMA acetate	53308-83-1	98%
T15697	L-NMMA acetate (Tilarginine acetate) is an inhibitor of nitric oxide synthase of all NOS isoforms (i.e. NOS1, NOS2, and NOS3). The Ki values are 0.18, 0.4, and 6...
T14149	AICAR phosphate	681006-28-0	98%
T14149	AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy, as well as an adenosine analog that regulates glucose ...
T10107	3-Bromo-7-nitroindazole	74209-34-0	98%
T10107	3-Bromo-7-nitroindazole is a more potent and selective inhibitor of neuronal nitric oxide synthase (nNOS) than eNOS or iNOS. It affects the intercellular messeng...
T9955	EX-A5758	308277-46-5	98%
T9955	EX-A5758 is a novel putative small molecule nNOS-NOS1AP inhibitor, suppressing inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes ...
T39020	Carboxyebselen	153871-75-1	98%
T39020	Carboxyebselen (HOOC-Ebs) is an endothelial nitric oxide synthase (eNOS) inhibitor that is potent and selective.
TN1058	Pelargonidin chloride	134-04-3	98%
TN1058	Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels t...
TN3694	Coniferaldehyde	20649-42-7	98%
TN3694	Coniferaldehyde can significantly inhibit the growth of viability of strains of Oenococcus oeni. Coniferaldehyde exerts anti-inflammatory properties by inducing ...
T17056	Tetrahydrobiopterin	17528-72-2	98%
T17056	Tetrahydrobiopterin (BH4) is a cofactor for aromatic amino acid hydroxylases and an essential cofactor for nitric oxide synthase (NOS), which is used in the stud...
T30219	AVE-9488	291756-32-6	98%
T30219	AVE-9488 is a novel endothelial NO synthase (eNOS) enhancer that upregulates eNOS expression, induces NO production, and may ameliorate portal hypertension.