T78606 |
P2X3-IN-1
|
2823331-49-1
|
98%
|
|
P2X3-IN-1 (example 7) is a P2X3 receptor inhibitor suitable for research on neurogenic diseases [1].
|
T78639 |
Oxidized ATP trisodium salt
|
71997-40-5
|
98%
|
|
Oxidized ATP trisodium salt (oATP) is a broad-spectrum inhibitor of P2 receptors, irreversibly antagonizing P2X7R activation and inhibiting c-reactive protein (C...
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T79115 |
P2X3 antagonist 38
|
2545974-71-6
|
98%
|
|
Compound 38, also known as Compound 4, is a potent, orally active P2X3 antagonist that demonstrates inhibitory activity with IC50 values of 0.132 µM, 0.165 µM, a...
|
T16399 |
Opiranserin
|
1441000-45-8
|
98%
|
|
Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is...
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T6526 |
GW791343 trihydrochloride
|
309712-55-8
|
98%
|
|
GW791343 trihydrochloride (GW791343 3HCl) is aHCl salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pI...
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T71155 |
NP-1815-PX
|
1239578-80-3
|
98%
|
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NP-1815-PX is a selective P2X4R antagonist with demonstrated anti-inflammatory effects and the capability to alleviate pain in chronic pain models. Additionally,...
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T36067 |
Bongkrekic acid
|
11076-19-0
|
98%
|
|
Bongkrekic acid (Bongkrekic Acid (ammonium salt)) is a mitochondrial toxin secreted by Burkholderia gladioli that inhibits adenine nucleotide translocase (ANT).B...
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TP2272 |
NF023 hexasodium
|
104869-31-0
|
98%
|
|
NF023 hexasodium is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X1, P2X3, P2X2, ...
|
T12568 |
PSB-12062
|
55476-47-6
|
99.97%
|
|
PSB-12062 (N-(p-Methylphenylsulfonyl)phenoxazine) is a potent and selective antagonist of P2X4(IC50 of 1.38 μM for human P2X4).
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T14844 |
BX430
|
688309-70-8
|
99.95%
|
|
BX430 is used for chronic pain and cardiovascular disease and it is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with...
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T61025 |
GSK-1482160
|
1001389-72-5
|
99.87%
|
|
GSK-1482160 is a CNS-penetrant negative allosteric modulator of P2X7 receptor with oral activity. The P2X7 receptor is involved in the production of pro-inflamma...
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T5513 |
RO-3
|
1026582-88-6
|
99.87%
|
|
RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor
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T15622 |
JNJ-54175446
|
1627902-21-9
|
99.83%
|
|
JNJ-54175446 (JNJ-5446) is a CNS-permeable and selective P2X7 receptor antagonist that attenuates the release of IL-1β/IL-18 from microglia, and may be used in t...
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T3639 |
A-804598
|
1125758-85-1
|
99.8%
|
|
A-804598 is a competitive and selective P2X7 receptor antagonist (IC50: 10 nM, rat; 9 nM, mouse; 11 nM, human).
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T4298 |
JNJ-47965567
|
1428327-31-4
|
99.76%
|
|
JNJ-47965567 (JNJ-479655) is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for huma...
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T22518 |
5-BDBD
|
768404-03-1
|
99.74%
|
|
5-BDBD is a potent and selective P2X4 receptor antagonist. 5-BDBD inhibits rP2X4R-mediated currents with an IC50 of 0.75 μM. 5-BDBD completely blocked the basal ...
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T5099 |
Gefapixant
|
1015787-98-0
|
99.72%
|
|
Gefapixant (AF219) is a P2X3 receptor (P2X3R) antagonist with IC50 of ~30 nM at recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors....
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T10207 |
A 438079
|
899507-36-9
|
99.70%
|
|
A 438079 is a potent, and selective antagonist of P2X7 receptor (pIC50: 6.9).
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T14385 |
AZD9056 hydrochloride
|
345303-91-5
|
99.52%
|
|
AZD9056 hydrochloride is a P2X7 inhibitor,Which plays a significant role in pain-causing diseases and inflammation.
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T14366 |
AZ10606120 dihydrochloride
|
607378-18-7
|
99.49%
|
|
AZ10606120 dihydrochloride is a selectable, potent, high-affinity receptor antagonist with K D values of 1.4 and 19 nM at human and rat P2X 7 receptors, respecti...
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